Results 41 to 50 of about 13,787 (250)

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

A case series and literature review on 98 pediatric patients of germ cell tumor developing growing teratoma syndrome

Cancer Medicine, 2023
Introduction Malignant germ cell tumors (MGCTs) can develop either extracranially or intracranially. Growing teratoma syndrome (GTS) may develop in these patients following chemotherapy.
Ming‐Yun Hsieh, Hsin‐Hung Chen, Chih‐Ying Lee, Giun‐Yi Hung, Tsung‐Yen Chang, Shih‐Hsiang Chen, Jin‐Yao Lai, Tang‐Her Jaing, Chao‐Neng Cheng, Jiann‐Shiuh Chen, Hsin‐Lin Tsai, Ting‐Yen Yu, Ming‐Hsin Hou, Cheng‐Yin Ho, Hsiu‐Ju Yen   +14 more
doaj   +1 more source

Assessing Homologous Recombination and Interstrand Cross-Link Repair in Embryonal Carcinoma Testicular Germ Cell Tumor Cell Lines

, 2020
testicular germ cell tumors (TGCTs) are typically exquisitely sensitive to DNA interstrand cross-link (ICLs) agents. ICLs covalently link both strands of the DNA duplex, impeding fundamental cellular processes like DNA replication to cause cell death.
Marco Barchi, Barchi, Marco, Francesca Cavallo, Cinzia Caggiano, Cavallo, Francesca, Caggiano, Cinzia, Jasin, Maria, Maria Jasin   +7 more
core   +1 more source

A rare case of mixed germ cell tumor in a teenage girl: a case report [PDF]

, 2017
Germ cell tumors represent only 20% to 25% of all benign and malignant ovarian neoplasms. Mixed germ cell tumors are a rare variety of non–dysgerminomatous germ cell tumors.
Aprateem Mukherjee, Parul I. Chaudhary, Kyal, Amit, Chaudhary, Parul I., Amit Kyal, Sujatha Das, Das, Sujatha, Mukhopadhyay, Partha, Faraz S. Vali, Partha Mukhopadhyay, Vali, Faraz S., Mukherjee, Aprateem   +11 more
core   +1 more source

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source

Primary embryonal carcinoma of the prostate

Urology Case Reports
Extragonadal germ cell tumors originating in the prostate are extremely rare. Thus far, less than 20 cases were described in the literature. To our knowledge, there are no published cases of primary embryonal carcinoma of the prostate.
Milan Radovanović, Aleksa Zubelić, Veljko Šantrić, Uroš Babić, Nebojša Prijović, Predrag Nikić   +5 more
doaj   +1 more source

Extragonadal germ-cell tumors – a review of the pathogenesis, histopathological findings, diagnosis and treatment [PDF]

Archives of the Balkan Medical Union, 2019
Primary extragonadal germ-cell tumors (EGCTs) are a rare group of neoplasms, that can exist anywere along the midline of the body, without the evidence of a primary gonadal tumor.
Lucian IORGA, Dragos MARCU, Ovidiu BRATU, Bogdan SOCEA, Tiberiu P. NEAGU, Simona BUNGAU, Ana Maria A. STANESCU, Camelia C. DIACONU, Dan MISCHIANU   +8 more
doaj   +1 more source

Non-seminomatous germ cell tumours

, 2014
The group of non-seminomatous germ cell tumors can be morphologically and therapeutically distinguished from the group of seminomas. The group of non-seminomatous germ cell tumors includes embryonal carcinoma, yolk sac tumor, choriocarcinoma and teratoma.
Behnes, Carl Ludwig, Bremmer, Felix, Schweyer, Stefan   +2 more
core   +1 more source

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

Primary pleuro-pulmonary malignant germ cell tumours

, 2002
Lungs and pleura are rare sites for malignant germ-cell tumours. Two cases, pure yolk-sac tumour and yolk sac-sac tumour/embryonal carcinoma are described in young males who presented with rapid progression of respiratory symptoms.
J. R. Deshpande, Pradeep Vaideeswar, N. A. Jambhekar   +2 more
core   +1 more source