Results 41 to 50 of about 12,778 (301)

Cell division promotes efficient retrotransposition in a stable L1 reporter cell line [PDF]

, 2013
Background: Long interspersed element type one (L1) actively modifies the human genome by inserting new copies of itself. This process, termed retrotransposition, requires the formation of an L1 ribonucleoprotein (RNP) complex, which must enter the ...
Ivics, Z., Zsuzsanna Izsvák, Lajos Mates, Ivics, Zoltán, Izsvák, Zsuzsanna, Martin, Sandra L., Xie, Y., An, Wenfeng, Mátés, Lajos, Xie, Yi, Yi Xie, Sandra L Martin, An, W., Mates, L., Martin, S.L., Izsvák, Z., Wenfeng An, Zoltán Ivics   +17 more
core   +1 more source

Germ Cell Tumor Presenting with Precocious Puberty in a Girl in United Arab Emirates

Dubai Medical Journal, 2020
We herein report a rare case of malignant mixed germ cell tumor comprising both an embryonal carcinoma (60%) and a yolk sac tumor (40%). A 7-year-old girl presented to the emergency department with persistent vaginal bleeding, abdominal pain, and ...
Asim Noor Rana, Hani Humad, Aeman Muhammad Asif, Dana Ghannam, Nadia Nadeem   +4 more
doaj   +1 more source

Cripto: expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors [PDF]

, 2016
Type II germ cell tumors arise after puberty from a germ cell that was incorrectly programmed during fetal life. Failure of testicular germ cells to properly differentiate can lead to the formation of germ cell neoplasia in situ of the testis; this ...
Looijenga, Leendert H. J., Looijenga, LHJ (Leendert), Gillis, Ad, Bowles, Josephine, Gillis, Ad J. M., Stoop, Hans, Koopman, P, Koopman, Peter, Burnet, Guillaume, Spiller, Cassy M., Spiller, CM, Burnet, G, Bouiles, J   +12 more
core   +3 more sources

Integrated Molecular Characterization of Testicular Germ Cell Tumors

Cell Reports, 2018
Summary: We studied 137 primary testicular germ cell tumors (TGCTs) using high-dimensional assays of genomic, epigenomic, transcriptomic, and proteomic features. These tumors exhibited high aneuploidy and a paucity of somatic mutations.
Hui Shen, Juliann Shih, Daniel P. Hollern, Linghua Wang, Reanne Bowlby, Satish K. Tickoo, Vésteinn Thorsson, Andrew J. Mungall, Yulia Newton, Apurva M. Hegde, Joshua Armenia, Francisco Sánchez-Vega, John Pluta, Louise C. Pyle, Rohit Mehra, Victor E. Reuter, Guilherme Godoy, Jeffrey Jones, Carl S. Shelley, Darren R. Feldman, Daniel O. Vidal, Davor Lessel, Tomislav Kulis, Flavio M. Cárcano, Kristen M. Leraas, Tara M. Lichtenberg, Denise Brooks, Andrew D. Cherniack, Juok Cho, David I. Heiman, Katayoon Kasaian, Minwei Liu, Michael S. Noble, Liu Xi, Hailei Zhang, Wanding Zhou, Jean C. ZenKlusen, Carolyn M. Hutter, Ina Felau, Jiashan Zhang, Nikolaus Schultz, Gad Getz, Matthew Meyerson, Joshua M. Stuart, Rehan Akbani, David A. Wheeler, Peter W. Laird, Katherine L. Nathanson, Victoria K. Cortessis, Katherine A. Hoadley, Linghua Wang, Liu Xi, David Wheeler, Daniel Hughes, Kyle Covington, Joy C. Jayaseelan, Viktoriya Korchina, Lora Lewis, Jianhong Hu, HarshaVardhan Doddapaneni, Donna Muzny, Richard Gibbs, Katherine A. Hoadley, Daniel Hollern, Benjamin G. Vincent, Shengjie Chai, Christof C. Smith, J. Todd Auman, Yan Shi, Shaowu Meng, Tara Skelly, Donghui Tan, Umadevi Veluvolu, Piotr A. Mieczkowski, Corbin D. Jones, Matthew D. Wilkerson, Saianand Balu, Tom Bodenheimer, Alan P. Hoyle, Stuart R. Jefferys, Lisle E. Mose, Janae V. Simons, Matthew G. Soloway, Jeffrey Roach, Joel S. Parker, D. Neil Hayes, Charles M. Perou, Juliann Shih, Andrew D. Cherniack, Matthew Meyerson, Gordon Saksena, Carrie Cibulskis, Steven E. Schumacher, Rameen Beroukhim, Stacey B. Gabriel, Reanne Bowlby, Andrew J. Mungall, Denise Brooks, Katayoon Kasaian, Adrian Ally, Miruna Balasundaram, Rebecca Carlsen, Dorothy Cheung, Eric Chuah, Noreen Dhalla, Robert A. Holt, Steven J.M. Jones, Yussanne Ma, Michael Mayo, Richard A. Moore, A. Gordon Robertson, Jacqueline E. Schein, Payal Sipahimalani, Angela Tam, Nina Thiessen, Tina Wong, Marco A. Marra, Hui Shen, Wanding Zhou, Peter W. Laird, Daniel J. Weisenberger, David J. Van Den Berg, Phillip H. Lai, Mario Berrios, Andrea Holbrook, Moiz S. Bootwalla, Dennis T. Maglinte, Joshua Armenia, Francisco Sánchez-Vega, Nikolaus Schultz, Debyani Chakravarty, Jianjiong Gao, Zachary Heins, Ritika Kundra, Angelica Ochoa, Minwei Liu, Chris Sander, Marc Ladanyi, Vesteinn Thorsson, Amie J. Radenbaugh, Yulia Newton, Joshua M. Stuart, Juok Cho, David I. Heiman, Michael S. Noble, Hailei Zhang, Gad Getz, Nils Gehlenborg, Gordon Saksena, Doug Voet, Pei Lin, Scott Frazer, Jaegil Kim, Michael S. Lawrence, Sam Meier, Timothy Defreitas, Lynda Chin, Apurva M. Hegde, Rehan Akbani, John N. Weinstein, Wenbin Liu, Gordon B. Mills, Yiling Lu, Louise C. Pyle, John Pluta, Katherine L. Nathanson, Satish K. Tickoo, Victor E. Reuter, Rohit Mehra, Leendert Looijenga, Alan H. Bryce, Flavio M. Cárcano, André L. Carvalho, Victoria K. Cortessis, Darren Feldman, Guilherme Godoy, Michael Ittmann, Jeffrey Jones, Tomislav Kulis, Seth Lerner, Davor Lessel, Katherine L. Nathanson, Carl S. Shelley, Daniel O. Vidal, Kristen M. Leraas, Tara M. Lichtenberg, Jay Bowen, Julie M. Gastier-Foster, Mark Gerken, Carmen Helsel, Nilsa C. Ramirez, Lisa Wise, Erik Zmuda, Sandra Cottingham, David Chesla, Charles Saller, Katherine Tarvin, Luiz Fernando Lopes, Cristovam Scapulatempo-Neto, Natália D.A. Aredes, Wolter Oosterhuis, Ad Gillis, Hans Stoop, Wil Eijkenboom, George Sandusky, Sue Ellen Martin, Manju Aron, Siamak Daneshmand, Hooman Djaladat, David Quinn, Tanya Dorff, Jochen K. Lennerz, Leigh B. Thorne, Marija Gamulin, Zeljko Kastelan, Tvrtko Hudolin, Christian Kubisch, Lori Boice, Mei Huang, Amy H. Perou, W. Kimryn Rathmell, Todd Pihl, Yunhu Wan, Qiang Sun, Rashi Naresh, Sudha Chudamani, Jia Liu, Laxmi Lolla, Ye Wu, Martin L. Ferguson, Jean C. Zenklusen, Ina Felau, Jiashan (Julia) Zhang, Margi Sheth, John A. Demchok, Liming Yang, Zhining Wang, Roy Tarnuzzer, Carolyn M. Hutter, Heidi J. Sofia, Tanja M. Davidsen   +240 more
doaj   +1 more source

Malignant Ovarian Mixed Germ Cell Tumor: a Rare Case [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2009
Background and Objectives: Mixed germ cell tumors of the ovary, uncommon but aggressive tumors are seen most often in young women or adolescent girls, and are generally curable if found and treated early.
Z. Ebrahimi, Z. Khalaji Nia
doaj   +2 more sources

A Case of Sarcoidosis Disseminated to Skeletal Tissues

International Journal of Medical Students, 2013
Sarcoidosis is a systemic granulomatous disease of unknown etiology that typically affects young adults. Diagnostic criteria for sarcoidosis include involvement of two or more of the following organ systems: 1) pulmonary infiltrates; 2) bilateral hilar ...
Edon Rabinowitz, Chinwe Ogedegbe, Joseph Feldman   +2 more
doaj   +1 more source

Assessing Homologous Recombination and Interstrand Cross-Link Repair in Embryonal Carcinoma Testicular Germ Cell Tumor Cell Lines

, 2020
testicular germ cell tumors (TGCTs) are typically exquisitely sensitive to DNA interstrand cross-link (ICLs) agents. ICLs covalently link both strands of the DNA duplex, impeding fundamental cellular processes like DNA replication to cause cell death.
Marco Barchi, Barchi, Marco, Francesca Cavallo, Cinzia Caggiano, Cavallo, Francesca, Caggiano, Cinzia, Jasin, Maria, Maria Jasin   +7 more
core   +1 more source

Formation of neural and epidermal lineages during the differentiation of human embryonal carcinomacells [PDF]

, 2003
Within the ectoderm of the developing human embryo, cell fate determination is largely modulated by factors activated by cell-to-cell signalling. In vertebrates, ectoderm primarily differentiates into neural cells that make up the central nervous system ...
Christie, Victoria Buyers
core  

Association of intratubular seminoma and intratubular embryonal carcinoma with invasive testicular germ cell tumors

, 2007
The classification of intratubular germ cell neoplasia of the testis includes an unclassified type (IGCNU), in addition to various other intratubular lesions that show specific forms of differentiation, such as intratubular seminoma and intratubular ...
Weiss, Lawrence M., Chu, Peiguo G., Lau, Sean K.   +2 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source