Results 41 to 50 of about 20,940 (309)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

A case report of recurrent testicular germ cell tumor in a patient with a history of primary pulmonary germ cell tumor and a review of the literature

Frontiers in Oncology
BackgroundCompared to testicular germ cell tumors, the incidence of extragonadal germ cell tumors (EGCTs) is relatively low. While the lungs are a common site for metastasis of malignant germ cell tumors, primary pulmonary germ cell tumors are extremely ...
Jian Tan, Jian Tan, Jinfeng Wu, Jinfeng Wu, Runqiang Yuan, Wei Li, Linfeng Li, Hongxing Huang, Hongxing Huang, Yangbai Lu   +9 more
doaj   +1 more source

Adult Pure Yolk Sac Tumor of The Testis. [PDF]

, 2012
Adult pure yolk sac tumor (YST) is extremely rare. In childhood pure yolk sac tumors are most frequently seen, whereas component of mixed germ cell testicular tumors observed in adults.
Jagtap, SV, Kshirsagar, AY, Nikumbh, DB
core  

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

Primary germ cell tumor of the liver

Journal of Pediatric Surgery Case Reports, 2019
Introduction: Germ cell tumors may present in various forms and sites, that may be gonadal or extragonadal. Extragonadal tumors are more frequent in children and can occur in the sacrococcygeal region, retroperitoneum, mediastinum, neck and pineal gland.
Mayara Caroline Amorim Fanelli, Alexandre Alberto Barros Duarte, Fernanda Kelly Marques de Souza, Amanda Soares de Medeiros, Carla Renata Pacheco Donato Macedo, Maria Teresa de Seixas Alves, Henrique Manoel Lederman, Simone Campos Vieira Abib   +7 more
doaj   +1 more source

A case series and literature review on 98 pediatric patients of germ cell tumor developing growing teratoma syndrome

Cancer Medicine, 2023
Introduction Malignant germ cell tumors (MGCTs) can develop either extracranially or intracranially. Growing teratoma syndrome (GTS) may develop in these patients following chemotherapy.
Ming‐Yun Hsieh, Hsin‐Hung Chen, Chih‐Ying Lee, Giun‐Yi Hung, Tsung‐Yen Chang, Shih‐Hsiang Chen, Jin‐Yao Lai, Tang‐Her Jaing, Chao‐Neng Cheng, Jiann‐Shiuh Chen, Hsin‐Lin Tsai, Ting‐Yen Yu, Ming‐Hsin Hou, Cheng‐Yin Ho, Hsiu‐Ju Yen   +14 more
doaj   +1 more source

Epidermal growth factor receptor is a marker for syncytiotrophoblastic cells in testicular germ cell tumors [PDF]

, 2018
The epidermal growth factor receptor (EGFR) has been implicated in the pathogenesis, therapy and prognosis of various tumor types. The aim of this study was to investigate EGFR expression in a large series of testicular germ cell tumors (TGCTs).
Hechelhammer, Lukas, Heitz, Philipp, Jochum, Wolfram, Odermatt, Bernhard, Störkel, Stephan   +4 more
core  

ZBTB16 is a sensitive and specific marker in detection of metastatic and extragonadal yolk sac tumour [PDF]

, 2017
Aims Accurate histological diagnosis and classification of germ cell tumours (GCTs) is key to informing successful therapeutic and surveillance strategy. The modern therapeutic approach for yolk sac tumour (YST) is highly curative.
Aron, Manju, Idrees, Muhammad T., Priemer, David S., Wei, Christina, Xiao, Guang-Qian, Yang, Qi   +5 more
core   +1 more source

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

Derivation and characteristics of pluripotent embryonic germ cells in duck

Poultry Science, 2010
Embryonic germ (EG) cells derived from primordial germ cells are undifferentiated and pluripotent stem cells. In our study, primordial germ cells isolated from the genital ridges of Beijing duck (Anas domestica) embryo at stage 28 were co-cultured with mice embryonic fibroblasts.
W, Guan, Y, Wang, L, Hou, L, Chen, X, Li, W, Yue, Y, Ma   +6 more
openaire   +2 more sources