Results 61 to 70 of about 24,196 (383)

Distinct requirements for energy metabolism in mouse primordial germ cells and their reprogramming to embryonic germ cells [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance Primordial germ cells (PGCs) are the origin of germ cells and are critically important for continuity of multicellular organisms. Although the unique characteristics of mouse PGCs have been described in gene expression and epigenome levels, the metabolomic and proteomic profiles of PGCs and their significance for PGC properties ...
Yohei Hayashi, Kei Otsuka, Masayuki Ebina, Kaori Igarashi, Asuka Takehara, Mitsuyo Matsumoto, Akio Kanai, Kazuhiko Igarashi, Tomoyoshi Soga, Yasuhisa Matsui   +9 more
openaire   +2 more sources

Prognostic factors in prostate and testis cancer [PDF]

, 1999
Human germ cell tumors (GCTs) may have variable histology and clinical behavior, depending on factors such as sex of the patient, age at clinical diagnosis, and anatomical site of the tumor.
Brussel, J.P. van, Mickisch, G.H.J.
core   +12 more sources

ErbBs inhibition by lapatinib blocks tumor growth in an orthotopic model of human testicular germ cell tumor [PDF]

, 2018
In this work, we have analyzed the expression of different members of the ErbB family in human samples of testicular germ cell tumors (GCTs). We observed expression of ErbB1 or ErbB2 in different tumor subtypes, but we also found high expression of ErbB3
Casanovas i Casanovas, Oriol, Castillo-Ávila, Wilmar, Condom i Mundó, Enric, García del Muro Solans, Xavier, Germà Lluch, José Ramón, Graupera i Garcia-Milà, Mariona, Hernández-Losa, Javier, Juliachs Milà, Mercè, Pandiella, Atanasio, Piulats, Josep M., Teixidó, C., Vidal-Bel, August, Villanueva Garatachea, Alberto, Viñals Canals, Francesc   +13 more
core   +1 more source

A Human Neural Tube Model Using 4D Self‐Folding Smart Scaffolds

Advanced Healthcare Materials, EarlyView.
Induced pluripotent stem cells (iPSCs) exhibit features comparable to the inner cell mass of the human embryo. iPSCs are applied to a novel self‐folding 4D‐Neural Tube (4D‐NT) structure that mimics the neurulation process. This 4D‐NT model recapitulates early events of human neural development and represents a platform to explore neurodevelopmental ...
Claudia Dell'Amico, Irene Chiesa, Angela Toffano, Alessio Esposito, Piera Mancini, Chiara Magliaro, Angeliki Louvi, Carmelo De Maria, Marco Onorati   +8 more
wiley   +1 more source

Challenges in the Treatment of a Refractory Testicular Germ Cell Tumor in Young Patients with Imminent Organ Failure—A Case Report

Journal of Mind and Medical Sciences
Background/Aim: This case report navigates through the challenges of a complex clinical scenario involving germ cell tumors (GCTs), one of the most frequently encountered malignancies in adolescents and young adults.
Iuliana Pantelimon, A. Stancu, Claudiu Socoliuc, Fikirie Abzait, I. Balescu, N. Bacalbaşa, C. Balalau, L. Galeș, I. Brezean   +8 more
semanticscholar   +1 more source

Cell division promotes efficient retrotransposition in a stable L1 reporter cell line [PDF]

, 2013
Background: Long interspersed element type one (L1) actively modifies the human genome by inserting new copies of itself. This process, termed retrotransposition, requires the formation of an L1 ribonucleoprotein (RNP) complex, which must enter the ...
An, Wenfeng, Ivics, Zoltán, Izsvák, Zsuzsanna, Martin, Sandra L., Mátés, Lajos, Xie, Yi   +5 more
core   +2 more sources

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source

A case report of recurrent testicular germ cell tumor in a patient with a history of primary pulmonary germ cell tumor and a review of the literature

Frontiers in Oncology
BackgroundCompared to testicular germ cell tumors, the incidence of extragonadal germ cell tumors (EGCTs) is relatively low. While the lungs are a common site for metastasis of malignant germ cell tumors, primary pulmonary germ cell tumors are extremely ...
Jian Tan, Jian Tan, Jinfeng Wu, Jinfeng Wu, Runqiang Yuan, Wei Li, Linfeng Li, Hongxing Huang, Hongxing Huang, Yangbai Lu   +9 more
doaj   +1 more source

A case series and literature review on 98 pediatric patients of germ cell tumor developing growing teratoma syndrome

Cancer Medicine, 2023
Introduction Malignant germ cell tumors (MGCTs) can develop either extracranially or intracranially. Growing teratoma syndrome (GTS) may develop in these patients following chemotherapy.
Ming‐Yun Hsieh, Hsin‐Hung Chen, Chih‐Ying Lee, Giun‐Yi Hung, Tsung‐Yen Chang, Shih‐Hsiang Chen, Jin‐Yao Lai, Tang‐Her Jaing, Chao‐Neng Cheng, Jiann‐Shiuh Chen, Hsin‐Lin Tsai, Ting‐Yen Yu, Ming‐Hsin Hou, Cheng‐Yin Ho, Hsiu‐Ju Yen   +14 more
doaj   +1 more source

Adult Pure Yolk Sac Tumor of The Testis. [PDF]

, 2012
Adult pure yolk sac tumor (YST) is extremely rare. In childhood pure yolk sac tumors are most frequently seen, whereas component of mixed germ cell testicular tumors observed in adults.
Jagtap, SV, Kshirsagar, AY, Nikumbh, DB
core