Results 61 to 70 of about 20,940 (309)

Extra-gonadal germ cell tumour – what about the testis! [PDF]

, 2011
Extra-gonadal germ cell tumours (EGGCT) are rare. Therefore further investigations of the testis is aimed at sourcing a possible primary origin of gonadal tumour. Over the years, various case series on EGGCT have been reported questioning its true nature
Christopher CKH,, Goh EH,, Johann FK,, Praveen S,, Razman J,, Zulkifli MZ,   +5 more
core  

Role of DNA repair machinery and p53 in the testicular germ cell cancer: a review [PDF]

, 2016
Notwithstanding the peculiar sensitivity to cisplatin-based treatment, resulting in a very high percentage of cures even in advanced stages of the disease, still we do not know the biological mechanisms that make Testicular Germ Cell Tumor (TGCT) "unique"
Ametrano, Gianluca, Berretta, Massimiliano, Botti, Gerardo, Cappuccio, Francesca, Caraglia, Michele, Castaldo, Luigi, Cavaliere, Carla, Ciliberto, Gennaro, Conteduca, Vincenza, D'Aniello, Carmine, De Falco, Francesco, De Giorgi, Ugo, Di Franco, Rossella, Facchini, Gaetano, Lamantia, Elvira, Maiolino, Piera, Malzone, Gabriella, Montanari, Micaela, Montella, Maurizio, Muto, Paolo, Nocerino, Flavia, Pepe, Maria Filomena, Perdonà, Sisto, Piscitelli, Raffaele, Quagliariello, Vincenzo, Romano, Francesco Jacopo, Rossetti, Sabrina, Schepisi, Giuseppe, Vanacore, Daniela, Veneziani, Bianca Maria   +29 more
core   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source

Bilateral Synchronous Testis Tumors of Different Histology: A Case Report

Caspian Journal of Internal Medicine, 2020
Background: Bilateral synchronous testis germ cell tumors with different histopathology are not common. Case Presentation: Here, a case of 27-year-old male who is reported presented with bilateral testicular swellings.
Ghasem Rostami, Hamid Shafi, Mohammad Ranaee, Samaneh Saeedfar, Fatemeh Mahmodloo   +4 more
doaj  

Chromosome X-encoded Cancer/Testis antigens are less frequently expressed in non-seminomatous germ cell tumors than in seminomas [PDF]

, 2013
Cancer/Testis (CT) antigens are normally only expressed in germ cells and yet are aberrantly activated in a wide variety of human cancers. Most chromosome X-encoded CT antigens (CT-X) show restricted expression in pre-meiotic germ cells in adult testis ...
Cao, Dengfeng, Chen, Yao-Tseng, Chiu, Rita, Lee, Peishan   +3 more
core   +2 more sources

A prospective study on contrast-enhanced magnetic resonance imaging of testicular lesions: distinctive features of Leydig cell tumours [PDF]

, 2015
OBJECTIVES: Up to 20 % of incidentally found testicular lesions are benign Leydig cell tumours (LCTs). This study evaluates the role of contrast-enhanced magnetic resonance imaging (MRI) in the identification of LCTs in a large prospective cohort study.
BERNARDO, SILVIA, CANTISANI, VITO, CATALANO, Carlo, GIANFRILLI, DANIELE, ISIDORI, Andrea, LENZI, Andrea, MANGANARO, Lucia, POFI, RICCARDO, POZZA, CARLOTTA, SALDARI, MATTEO, Scialpi, M, VINCI , VALERIA   +11 more
core   +1 more source

Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

Advanced Science, EarlyView.
Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang, David W. McKellar, Andrew Kowalczewski, Nhu Y. Mai, Meng Chai, Xiaojun L. Lian, Yi Zheng, Jeffrey Amack, Nathan Tucker, Iwijn De Vlaminck, Huaxiao Yang, Benjamin D. Cosgrove, Zhen Ma   +12 more
wiley   +1 more source

Cell Germ primary tumor of mediastinum (seminoma of mediastinum)

Archivo Médico de Camagüey, 2019
Background: the anterior mediastinal germ cell tumor is a formation of neoplastic cells located in the mediastinum. They are formed by congenital defects in the embryonic stage by migration of the primordial germ cell and dermal cells that are within the
René Hernández-Benedicto, Rafael Pila-Pérez, Pedro Rosales-Torres   +2 more
doaj  

Imprinting Status of Gα_S, NESP55, and XLαs in Cell Cultures Derived from Human Embryonic Germ Cells: GNAS Imprinting in Human Embryonic Germ Cells [PDF]

Clinical and Translational Science, 2009
Abstract GNAS is a complex gene that through use of alternative first exons encodes signaling proteins Gαs and XLαs plus neurosecretory protein NESP55. Tissue‐specific expression of these proteins is regulated through reciprocal genomic imprinting in fully differentiated and developed tissue.
Janet L, Crane, Michael J, Shamblott, Joyce, Axelman, Stephanie, Hsu, Michael A, Levine, Emily L, Germain-Lee   +5 more
openaire   +2 more sources