Results 71 to 80 of about 24,196 (383)

ZBTB16 is a sensitive and specific marker in detection of metastatic and extragonadal yolk sac tumour [PDF]

, 2017
Aims Accurate histological diagnosis and classification of germ cell tumours (GCTs) is key to informing successful therapeutic and surveillance strategy. The modern therapeutic approach for yolk sac tumour (YST) is highly curative.
Aron, Manju, Idrees, Muhammad T., Priemer, David S., Wei, Christina, Xiao, Guang-Qian, Yang, Qi   +5 more
core   +1 more source

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

Primary germ cell tumor of the liver

Journal of Pediatric Surgery Case Reports, 2019
Introduction: Germ cell tumors may present in various forms and sites, that may be gonadal or extragonadal. Extragonadal tumors are more frequent in children and can occur in the sacrococcygeal region, retroperitoneum, mediastinum, neck and pineal gland.
Mayara Caroline Amorim Fanelli, Alexandre Alberto Barros Duarte, Fernanda Kelly Marques de Souza, Amanda Soares de Medeiros, Carla Renata Pacheco Donato Macedo, Maria Teresa de Seixas Alves, Henrique Manoel Lederman, Simone Campos Vieira Abib   +7 more
doaj   +1 more source

Comprehensive genetic analysis of pediatric germ cell tumors identifies potential drug targets

Communications Biology, 2020
To elucidate the molecular pathogenesis of pediatric germ cell tumors (GCTs), we performed DNA methylation array analysis, whole transcriptome sequencing, targeted capture sequencing, and single-nucleotide polymorphism array analysis using 51 GCT samples
Y. Kubota, M. Seki, T. Kawai, Tomoya Isobe, Misa Yoshida, M. Sekiguchi, Shunsuke Kimura, Kentaro Watanabe, A. Sato-Otsubo, Kenichi Yoshida, Hiromichi Suzuki, K. Kataoka, Y. Fujii, Y. Shiraishi, K. Chiba, Hiroko Tanaka, M. Hiwatari, A. Oka, Y. Hayashi, S. Miyano, S. Ogawa, K. Hata, Yukichi Tanaka, J. Takita   +23 more
semanticscholar   +1 more source

Epidermal growth factor receptor is a marker for syncytiotrophoblastic cells in testicular germ cell tumors [PDF]

, 2018
The epidermal growth factor receptor (EGFR) has been implicated in the pathogenesis, therapy and prognosis of various tumor types. The aim of this study was to investigate EGFR expression in a large series of testicular germ cell tumors (TGCTs).
Hechelhammer, Lukas, Heitz, Philipp, Jochum, Wolfram, Odermatt, Bernhard, Störkel, Stephan   +4 more
core  

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Extragonadal germ-cell tumors – a review of the pathogenesis, histopathological findings, diagnosis and treatment [PDF]

Archives of the Balkan Medical Union, 2019
Primary extragonadal germ-cell tumors (EGCTs) are a rare group of neoplasms, that can exist anywere along the midline of the body, without the evidence of a primary gonadal tumor.
Lucian IORGA, Dragos MARCU, Ovidiu BRATU, Bogdan SOCEA, Tiberiu P. NEAGU, Simona BUNGAU, Ana Maria A. STANESCU, Camelia C. DIACONU, Dan MISCHIANU   +8 more
doaj   +1 more source

Pluripotent human stem cells: Standing on the shoulders of giants [PDF]

, 2016
The advent of human pluripotent stem cells, with the first derivation of human embryonic stem cells in 1998, and of human induced pluripotent stem cells in 2007, has ushered in an era of considerable excitement about the prospects of using these cells to
Andrews, P.W., Damjanov, I.
core   +1 more source

Derivation and characteristics of pluripotent embryonic germ cells in duck

Poultry Science, 2010
Embryonic germ (EG) cells derived from primordial germ cells are undifferentiated and pluripotent stem cells. In our study, primordial germ cells isolated from the genital ridges of Beijing duck (Anas domestica) embryo at stage 28 were co-cultured with mice embryonic fibroblasts.
W, Guan, Y, Wang, L, Hou, L, Chen, X, Li, W, Yue, Y, Ma   +6 more
openaire   +2 more sources

IL1R2 Marks and Sorts a Spermatogonial Stem Cell Population Critical for Restoring Spermatogenesis Upon Interruption in Mammals

Advanced Science, EarlyView.
Spermatogonial stem cells (SSCs) provide critical support to spermatogenesis. Here, the author established Il1r2 as a sorting marker for SSCs, with which further insights into the SSC heterogeneity and dynamic features can be obtained. They also confirmed findings in both mouse and human, thus validating IL1R2 as the surface marker for isolating and ...
Pengyu Li, Zexuan Zhang, Zihan Xie, Cheng Jin, Zhipeng Wang, Changwei Yuan, Jun Zhu, Jielin Tang, Mengzhen Li, Dingfeng Zou, Xinyu Mang, Jun Liu, Dingyao Chen, Qi Geng, Yan Lu, Ning Zhang, Shiying Miao, Jing Peng, Kai Li, Wei Song   +19 more
wiley   +1 more source