Localized ultraviolet laser microbeam irradiation of early Drosophila embryos: Fate maps based on location and frequency of adult defects [PDF]
, 1979 Drosophila embryos were locally irradiated with a 257-nm laser microbeam during blastoderm and germ band stages. Depending on stage and beam diameter (10–30 μm), from 0 to 45 nuclei were exposed to the uv radiation.
Cremer, Christoph +4 more
core +1 more source
PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation. [PDF]
, 2018 Germ cell tumors (GCTs) are a heterogeneous group of tumors occurring in gonadal and extragonadal locations. GCTs are hypothesized to arise from primordial germ cells (PGCs), which fail to differentiate.
Chen, Di +4 more
core +2 more sources
CPEB3 Maintains Developmental Competence of the Oocyte
CellsMammalian oocyte development depends on the temporally controlled translation of maternal transcripts, particularly in the coordination of meiotic and early embryonic development when transcription has ceased.
Lucie Lamacova +9 more
doaj +1 more source
Primary Culture System for Germ Cells from Caenorhabditis elegans Tumorous Germline Mutants
Bio-Protocol, 2017 The Caenorhabditis elegans germ line is an important model system for the study of germ stem cells. Wild-type C. elegans germ cells are syncytial and therefore cannot be isolated in in vitro cultures. In contrast, the germ cells from tumorous mutants can
Alexandra Vagasi +3 more
doaj +1 more source
Cell cycle regulation for meiosis in mammalian germ cells
The Journal of Reproduction and Development, 2023 In mouse fetal gonads, germ cell development is accompanied by changes in cell cycle mode in response to external signals and intrinsic mechanisms of cells.
Ryuki SHIMADA, Kei-ichiro ISHIGURO
doaj +1 more source
An Extended Culture System that Supports Human Primordial Germ Cell-like Cell Survival and Initiation of DNA Methylation Erasure. [PDF]
, 2020 The development of an in vitro system in which human primordial germ cell-like cells (hPGCLCs) are generated from human pluripotent stem cells (hPSCs) has been invaluable to further our understanding of human primordial germ cell (hPGC) specification ...
Bower, Grace +9 more
core
Plasma and testicular testosterone levels, volume density and number of Leydig cells and spermatogenic efficiency of rabbits [PDF]
, 2002 Plasma and tissue testosterone concentrations were determined by radioimmunoassay in 12 eight-month-old sexually mature New Zealand White rabbits and evaluated for possible associations with spermatogenic efficiency as well as with volume density and ...
Berndtson, William E. +2 more
core +2 more sources
piRNA pathway targets active LINE1 elements to establish the repressive H3K9me3 mark in germ cells
Genes & Development, 2014 Transposable elements (TEs) occupy a large fraction of metazoan genomes and pose constant threats to genomic integrity. Small noncoding piwi-interacting RNAs (piRNAs) recognize and silence a diverse set of TEs in germ cells. Pezic et al.
Dubravka Pezic +3 more
semanticscholar +1 more source
PLoS ONE, 2011 Differentiation of germ cells into male gonocytes or female oocytes is a central event in sexual reproduction. Proliferation and differentiation of fetal germ cells depend on the sex of the embryo.
Anne-Amandine Chassot +6 more
doaj +1 more source
Over Expression of NANOS3 and DAZL in Human Embryonic Stem Cells. [PDF]
PLoS ONE, 2016 The mechanisms underlying human germ cell development are largely unknown, partly due to the scarcity of primordial germ cells and the inaccessibility of the human germline to genetic analysis.
Sarita Panula +12 more
doaj +1 more source