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YY1 Is Required for Germinal Center B Cell Development. [PDF]
PLoS ONE, 2016 YY1 has been implicated as a master regulator of germinal center B cell development as YY1 binding sites are frequently present in promoters of germinal center-expressed genes. YY1 is known to be important for other stages of B cell development including
Anupam Banerjee +6 more
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Acute SIV infection in sooty mangabey monkeys is characterized by rapid virus clearance from lymph nodes and absence of productive infection in germinal centers. [PDF]
PLoS ONE, 2013 Lymphoid tissue immunopathology is a characteristic feature of chronic HIV/SIV infection in AIDS-susceptible species, but is absent in SIV-infected natural hosts.
Amanda J Martinot +9 more
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B cell-intrinsic IRF-1 and conserved gammaherpesvirus protein kinase cooperate to promote murine gammaherpesvirus-driven germinal center response and splenic latent reservoir [PDF]
Journal of VirologyGammaherpesviruses infect >90% of adults and are associated with B cell lymphomas. These viruses drive the expansion and differentiation of germinal center B cells to amplify latent viral reservoir and ensure life-long infection of memory B cells ...
Cade R. Rahlf +3 more
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Gammaherpesvirus infection unveils exaggerated germinal center responses in an SR-BI-deficient host [PDF]
Journal of VirologyLipid metabolism has emerged as an important regulator of acute viral infections by affecting viral replication and the host immune response. In contrast, the role of host lipid metabolism during chronic viral infection has been less explored.
Damon L. Schmalzriedt +6 more
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Cells, 2021 Germinal centers (GCs) are transient structures in the secondary lymphoid organs, where B cells undergo affinity maturation to produce high affinity memory and plasma cells.
Theinmozhi Arulraj +2 more
doaj +1 more source
Annual Review of Immunology, 2012 Germinal centers (GCs) were described more than 125 years ago as compartments within secondary lymphoid organs that contained mitotic cells. Since then, it has become clear that this structure is the site of B cell clonal expansion, somatic hypermutation, and affinity-based selection, the combination of which results in the production of high-affinity ...
Gabriel D, Victora +1 more
openaire +4 more sources
Frontiers in Immunology, 2022 The development of a safe and effective vaccine against Yersinia pestis, the causative organism for plague disease, remains an important global health priority.
Darrell R. Galloway +8 more
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Antibody Mediated Intercommunication of Germinal Centers
Cells, 2022 Antibody diversification and selection of B cells occur in dynamic structures called germinal centers (GCs). Passively administered soluble antibodies regulate the GC response by masking the antigen displayed on follicular dendritic cells (FDCs).
Theinmozhi Arulraj +2 more
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Analysis of immunophenotypic features in hyaline vascular type Castleman disease
Diagnostic Pathology, 2023 Background Studies suggested that the immunophenotype of hyaline vascular type Castleman disease (HVCD) lacked characteristics, which was easy to be confused with other diseases. Methods From January 2010 to June 2022, 17 cases of HVCD were selected from
Yu Chang, Yu Ma, Chen Chang, Wensheng Li
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Distinctive High Expression of Antiretroviral APOBEC3 Protein in Mouse Germinal Center B Cells
Viruses, 2022 Tissue and subcellular localization and its changes upon cell activation of virus-restricting APOBEC3 at protein levels are important to understanding physiological functions of this cytidine deaminase, but have not been thoroughly analyzed in vivo.
Shota Tsukimoto +8 more
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