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Regulation of the Germinal Center Response [PDF]
Frontiers in Immunology, 2018 The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid tissues, producing long-lived antibody secreting plasma cells and memory B cells, which can provide protection against reinfection.
Marisa Stebegg +8 more
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PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma
The Journal of Clinical Investigation, 2022 The synthesis of serine from glucose is a key metabolic pathway supporting cellular proliferation in healthy and malignant cells. Despite this, the role that this aspect of metabolism plays in germinal center biology and pathology is not known.
Annalisa D’Avola +16 more
doaj +2 more sources
Cytokines in the Germinal Center Niche [PDF]
Antibodies, 2016 Cytokines are small, secreted, glycoproteins that specifically affect the interactions and communications between cells. Cytokines are produced transiently and locally, acting in a paracrine or autocrine manner, and they are extremely potent, ligating ...
Christoph Jandl, Cecile King
doaj +5 more sources
Germinal Center Optimization Algorithm [PDF]
International Journal of Computational Intelligence Systems, 2018 Artificial immune systems are metaheuristic algorithms that mimic the adaptive capabilities of the immune system of vertebrates. Since the 1990s, they have become one of the main branches of computer intelligence.
Carlos Villaseñor +4 more
doaj +3 more sources
Germinal Centers without T Cells [PDF]
The Journal of Experimental Medicine, 2000 Germinal centers are critical for affinity maturation of antibody (Ab) responses. This process allows the production of high-efficiency neutralizing Ab that protects against virus infection and bacterial exotoxins. In germinal centers, responding B cells selectively mutate the genes that encode their receptors for antigen.
Carola G. Vinuesa +8 more
openalex +4 more sources
Sustained antigen delivery improves germinal center reaction and increases antibody responses in neonatal mice [PDF]
npj VaccinesNeonates and young infants are known to have limited responses to pediatric vaccines due to reduced germinal center formation. Extended vaccine antigen dosing was previously shown to expand germinal center formation and improve humoral responses in adult
Leda Lotspeich-Cole +6 more
doaj +2 more sources
Defects in germinal center selection in SLE [PDF]
Frontiers in Immunology, 2015 Germinal centers (GCs) are the primary site at which clonal expansion and affinity maturation of B cells occurs. B cells encounter antigen and receive T cell help in the GC light zone (LZ) and then migrate to the dark zone where they proliferate and ...
Megan eWoods +2 more
doaj +4 more sources
Annual Review of Immunology, 2012 Germinal centers (GCs) were described more than 125 years ago as compartments within secondary lymphoid organs that contained mitotic cells. Since then, it has become clear that this structure is the site of B cell clonal expansion, somatic hypermutation, and affinity-based selection, the combination of which results in the production of high-affinity ...
Gabriel D, Victora +1 more
openaire +5 more sources
Cells, 2021 Germinal centers (GCs) are transient structures in the secondary lymphoid organs, where B cells undergo affinity maturation to produce high affinity memory and plasma cells.
Theinmozhi Arulraj +2 more
doaj +1 more source
bioRxiv, 2023 Clarke and colleagues show that germinal center B cells have highly dynamic mitochondria, which are regulated by the transcription factor TFAM. TFAM activity is required to promote spatial entry into the germinal center reaction by modulating cellular ...
Yavuz F. Yazicioglu +7 more
semanticscholar +1 more source