Results 1 to 10 of about 181,469 (346)

Optimality of mutation and selection in germinal centers [PDF]

PLoS Computational Biology, 2010
The population dynamics theory of B cells in a typical germinal center could play an important role in revealing how affinity maturation is achieved. However, the existing models encountered some conflicts with experiments. To resolve these conflicts, we
Arup K. Chakraborty, BP O'Connor, C Berek, C Berek, C Kesmir, C Kocks, CD Allen, CD Allen, D Iber, D Paus, E Brunet, Eugene I. Shakhnovich, F Celada, F Coffey, FD Batista, FG Kroese, G Shahaf, GJ Wedemayer, H Torigoe, HD Ulrich, IC MacLennan, IM Rouzine, IM Rouzine, J Jacob, J Jacob, J Jacob, J Sharon, J Sharon, J Zhang, Jingshan Zhang, K Rajewsky, KG Smith, LS Tsimring, M Meyer-Hermann, M Oprea, M Or-Guil, M Shannon, M Siekevitz, M Ziegner, MD Kumar, MD Radmacher, ME Meyer-Hermann, MG Hanna Jr, MG McHeyzer-Williams, MJ Shlomchik, MM Desai, MS Neuberger, MW Deem, PL Yang, R Kuppers, S Han, SH Kleinstein, TA Schwickert, TB Kepler, TB Kepler, V Pascual, YJ Liu   +56 more
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YY1 Is Required for Germinal Center B Cell Development. [PDF]

PLoS ONE, 2016
YY1 has been implicated as a master regulator of germinal center B cell development as YY1 binding sites are frequently present in promoters of germinal center-expressed genes. YY1 is known to be important for other stages of B cell development including
Atchison, Michael L, Banerjee, Anupam, Hodewadekar, Suchita, Jha, Vibha, Manser, Tim, Sindhava, Vishal, Vuyyuru, Raja   +6 more
core   +15 more sources

Regulation of the Germinal Center Response [PDF]

Frontiers in Immunology, 2018
The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid tissues, producing long-lived antibody secreting plasma cells and memory B cells, which can provide protection against reinfection. Within the GC, B cells undergo somatic mutation of the genes encoding their B cell receptors which, following successful selection ...
Marisa Stebegg, Saumya D. Kumar, Saumya D. Kumar, Alyssa Silva-Cayetano, Valter R. Fonseca, Valter R. Fonseca, Michelle A. Linterman, Luis Graca, Luis Graca   +8 more
openaire   +4 more sources

Cytokines in the Germinal Center Niche [PDF]

Antibodies, 2016
Cytokines are small, secreted, glycoproteins that specifically affect the interactions and communications between cells. Cytokines are produced transiently and locally, acting in a paracrine or autocrine manner, and they are extremely potent, ligating high affinity cell surface receptors to elicit changes in gene expression and protein synthesis in the
Christoph Jandl, Christoph Jandl, Cecile King, Cecile King   +3 more
openaire   +6 more sources

Germinal Centers [PDF]

Annual Review of Immunology, 2012
Germinal centers (GCs) were described more than 125 years ago as compartments within secondary lymphoid organs that contained mitotic cells. Since then, it has become clear that this structure is the site of B cell clonal expansion, somatic hypermutation, and affinity-based selection, the combination of which results in the production of high-affinity ...
Gabriel D, Victora, Michel C, Nussenzweig   +1 more
openaire   +5 more sources

Germinal centers and autoantibodies [PDF]

Immunology & Cell Biology, 2020
AbstractPreventing self‐reactive lymphocytes from participating in effector responses is fundamental to maintaining immunological self‐tolerance and circumventing autoimmunity. A range of complementary mechanisms are known to act upon the primary B‐ and T‐cell repertoires to this effect, eliminating or silencing lymphocytes expressing self‐reactive ...
Clara Young, Clara Young, Robert Brink, Robert Brink   +3 more
openaire   +3 more sources

Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease: the salivary glands of patients with Sjögren's syndrome [PDF]

, 1998
Structures resembling germinal centers are seen in the salivary glands of patients with Sjögren's syndrome, but it is not known whether the microenvironment of these cell clusters is sufficient for the induction of a germinal center response.
Berek, C., Hiepe, F., Hummel, M., Steinhauser, G., Stott, D.I.   +4 more
core   +2 more sources

Synaptic Interactions in Germinal Centers [PDF]

Frontiers in Immunology, 2018
The germinal center (GC) is a complex, highly dynamic microanatomical niche that allows the generation of high-affinity antibody-producing plasma cells and memory B cells. These cells constitute the basis of long-lived highly protective antibody responses.
Papa, Ilenia, Garcia De Vinuesa, Maria Carola   +1 more
openaire   +5 more sources

Artery tertiary lymphoid organs control multi-layered territorialized atherosclerosis B cell responses in aged ApoE-/- mice [PDF]

, 2016
Objective: Explore aorta B cell immunity in aged ApoE-/- mice. Approach and Results: Transcript maps, FACS, immunofluorescence analyses, cell transfers, and Ig-ELISPOT assays showed multi-layered atherosclerosis B cell responses in artery tertiary ...
Andreas J.R. Habenicht, Changjun Yin, Christian Weber, Coleen A. McNamara, Desheng Hu, Gianluca Grassia, Kulkarni U, Li Peng, Michael Beer, Pasquale Maffia, Prasad Srikakulapu, Rudolf A. Manz, Sai Vineela Bontha, Sarajo K. Mohanta   +13 more
core   +1 more source

The Biology of the Germinal Center [PDF]

Hematology, 2007
The immune system requires the production of high affinity antibodies of different subclasses to accomplish its many effector functions. Specific steps in B-cell ontogeny that occur within germinal centers of secondary lymphoid organs create much of the diversity in the immune system.
openaire   +3 more sources