Results 111 to 120 of about 181,469 (346)

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Weedy Adaptation in Setaria spp.: VIII. Structure of Setaria faberi Seed, Caryopsis and Embryo Germination [PDF]

arXiv, 2014
Giant foxtail (Setaria faberi) seeds differ in requirements for germination. Variable germinability arises during seed development under the influence of genotype, environment and parent plant. Giant foxtail seed germination has been shown to be regulated by independent asynchronous or dependent synchronous action of seed structures.
arxiv  

Latent Epstein-Barr virus infection and the germinal center reaction [PDF]

, 2007
Epstein-Barr virus (EBV) is a γ-herpes virus which preferentially infects human B lymphocytes. It is highly adapted to persist in B cells since it encodes for proteins which mimic several cellular proteins playing an important role in B cell ...
Rastelli, Julia
core  

CD98hc facilitates B cell proliferation and adaptive humoral immunity. [PDF]

, 2009
The proliferation of antigen-specific lymphocytes and resulting clonal expansion are essential for adaptive immunity. We report here that B cell-specific deletion of the heavy chain of CD98 (CD98hc) resulted in lower antibody responses due to total ...
A Mondino, AP Warren, AW Freidman, C Brakebusch, CA Fenczik, CA Fenczik, CC Feral, CC Feral, Cecille D Browne, CG Lo, CG Proud, Chloé C Féral, CL Abram, D Torrents, DC Otero, DE White, DM Rose, E Arana, F Esteban, FD Batista, FM Burnet, GW Prager, H Tsumura, J Bertran, J Fernandez-Herrera, J Hasbold, JG Cyster, JH Kehrl, JL Walker, Joseph Cantor, K Hara, K Roovers, KB Lin, KL Wolniak, L Kass, L Van Parijs, LA Diaz Jr., MA Schwartz, Mark H Ginsberg, MD Cooper, ML Motti, NC Henderson, R Zent, Raphael Ruppert, RC Rickert, Reinhard Fässler, RK Assoian, RO Hynes, Robert C Rickert, RT Abraham, SG Tangye, SJ Fleire, T Lammermann, T Uinuk-Ool, TN Sims, TT Lu, Y Shimizu   +56 more
core   +2 more sources

Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance

Molecular Oncology, EarlyView.
In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang, Haimei Wen, Ying Chen, Jingya Ning, Di Hu, Yujiao Dong, Chenyu Yao, Bo Yuan, Shuanying Yang   +8 more
wiley   +1 more source

Does Recycling in Germinal Centers Exist? [PDF]

Immunol. Cell Biol. 80 (2002) 30-35, 2001
A general criterion is formulated in order to decide if recycling of B-cells exists in GC reactions. The criterion is independent of the selection and affinity maturation process and based solely on total centroblast population arguments. An experimental test is proposed to verify whether the criterion is fulfilled.
arxiv  

γδ T cells affect IL-4 production and B-cell tolerance [PDF]

, 2014
γδ T cells can influence specific antibody responses. Here, we report that mice deficient in individual γδ T-cell subsets have altered levels of serum antibodies, including all major subclasses, sometimes regardless of the presence of αβ T cells.
Andrew Getahun, Cohen, Finkelman, Gerber, Greg A. Kirchenbaum, Hidaka, Hirose, Hua Huang, Izui, John C. Cambier, Koichi Ikuta, Kubo, Lawrence J. Wysocki, M. Kemal Aydintug, Rebecca L. O’Brien, Ryan A. Heiser, Simon R. Carding, Sperling, Sunaga, Tamara L. Casper, Thiago O. Detanico, Willi K. Born, Yafei Huang   +22 more
core   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

An analysis of B cell selection mechanisms in germinal centers [PDF]

Math Med Biol 23 (2006) 255, 2006
Affinity maturation of antibodies during immune responses is achieved by multiple rounds of somatic hypermutation and subsequent preferential selection of those B cells that express B cell receptors with improved binding characteristics for the antigen. The mechanism underlying B cell selection has not yet been defined.
arxiv