Results 121 to 130 of about 3,641,641 (357)
Molecular Oncology, EarlyView.RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha +10 more
wiley +1 more source
FACS Staining for Follicular Helper T Cells
Bio-Protocol, 2012 Germinal center is the primary site for B cells to undergo somatic hypermutation and class switching. A recently discovered subset of T cells known as T follicular helper (TFH) cells are essential for germinal center reaction and thus have been the ...
Zheng Liu
doaj +1 more source
LOCALIZATION OF IMMUNOLOGICAL COMPLEXES FIXING ß1C (C3) IN GERMINAL CENTERS OF LYMPH NODES [PDF]
, 1969 K Gajl-Peczalska +4 more
openalex +1 more source
Germinal Center and Extrafollicular B Cell Responses in Vaccination, Immunity, and Autoimmunity.
Immunity, 2020 Rebecca A. Elsner, M. Shlomchik
semanticscholar +1 more source
The microanatomic segregation of selection by apoptosis in the germinal center
Science, 2017 Light- and dark-zone death dynamics Germinal centers (GCs) are areas within lymphoid organs where mature B cells expand and differentiate during normal immune responses.
C. Mayer +12 more
semanticscholar +1 more source
Germinal centers are free for all [PDF]
The Journal of Experimental Medicine, 2007 ![Graphic][1] The offspring of two types of B cell clones (red and yellow) are present in several germinal centers (numbered) in a human lymph node (blue). Germinal centers (GCs)—the sites of antibody development—are not exclusive niches for rookie B cells.
openaire +2 more sources
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
RELATIONSHIP OF GERMINAL CENTERS IN LYMPHOID TISSUE TO IMMUNOLOGICAL MEMORY
, 1968 James Wakefield, G. J. Thorbecke
openalex +2 more sources
The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity
Molecular Oncology, EarlyView.Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause +6 more
wiley +1 more source