Results 161 to 170 of about 3,782,491 (387)
Histone Demethylase LSD1 is required for Germinal Center formation and BCL6-driven lymphomagenesis
Nature Immunology, 2018 Germinal center (GC) B cells feature repression of many gene enhancers to establish their characteristic transcriptome. Here we show that conditional deletion of Lsd1 in GCs significantly impaired GC formation, associated with failure to repress immune ...
K. Hatzi +16 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Nrk, an X-linked Protein Kinase in the Germinal Center Kinase Family, Is Required for Placental Development and Fetoplacental Induction of Labor [PDF]
, 2011 Kimitoshi Denda +8 more
openalex +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
SETD2 Haploinsufficiency Enhances Germinal Center–Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis [PDF]
, 2022 Wilfred Leung +18 more
openalex +1 more source
Germinal Center and Extrafollicular B Cell Responses in Vaccination, Immunity, and Autoimmunity.
Immunity, 2020 Rebecca A. Elsner, M. Shlomchik
semanticscholar +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Association of Cystic Medial Necrosis of the Aorta and Undiagnosed Thyroiditis [Scripta Medica] [PDF]
, 1977 We have recently seen two patients with cystic medial necrosis of the aorta. The first patient died of a dissecting aneurysm of the thoracic aorta. At autopsy, classical Hashimoto’s thyroiditis was discovered.
Hain, John R., Wise, William S.
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source