Results 11 to 20 of about 3,782,491 (387)

PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma

The Journal of Clinical Investigation, 2022
The synthesis of serine from glucose is a key metabolic pathway supporting cellular proliferation in healthy and malignant cells. Despite this, the role that this aspect of metabolism plays in germinal center biology and pathology is not known.
Annalisa D’Avola, Nathalie Legrave, Mylène Tajan, Probir Chakravarty, Ryan L. Shearer, Hamish W. King, Katarina Kluckova, Eric C. Cheung, Andrew J. Clear, Arief S. Gunawan, Lingling Zhang, Louisa K. James, James I. MacRae, John G. Gribben, Dinis P. Calado, Karen H. Vousden, John C. Riches   +16 more
doaj   +2 more sources

Synchronous Germinal Center Onset Impacts the Efficiency of Antibody Responses

Frontiers in Immunology, 2019
The germinal center reaction is an important target for modulating antibody responses. Antibody production from germinal centers is regulated by a negative feedback mechanism termed antibody feedback.
Theinmozhi Arulraj, Sebastian C. Binder, Sebastian C. Binder, Philippe A. Robert, Michael Meyer-Hermann, Michael Meyer-Hermann, Michael Meyer-Hermann   +6 more
doaj   +2 more sources

Regulation of the Germinal Center Response

Frontiers in Immunology, 2018
The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid tissues, producing long-lived antibody secreting plasma cells and memory B cells, which can provide protection against reinfection.
Marisa Stebegg, Saumya D. Kumar, Saumya D. Kumar, Alyssa Silva-Cayetano, Valter R. Fonseca, Valter R. Fonseca, Michelle A. Linterman, Luis Graca, Luis Graca   +8 more
doaj   +2 more sources

Exit from germinal center to become quiescent memory B cells depends on metabolic reprograming and provision of a survival signal

Journal of Experimental Medicine, 2020
Inoue et al. show that a small population of germinal center–derived CD38intBcl6hi/intEfnb1+ cells with lower mTORC1 activity favors a memory B cell fate.
Takeshi Inoue, Ryo Shinnakasu, Kawai Chie, Wataru Ise, Eiryo Kawakami, Nicolas Sax, Toshihiko Oki, Toshio Kitamura, Kazuo Yamashita, Hidehiro Fukuyama, Tomohiro Kurosaki   +10 more
openalex   +3 more sources

Novel specialized cell state and spatial compartments within the germinal center

Nature Immunology, 2020
Within germinal centers (GCs), complex and highly orchestrated molecular programs must balance proliferation, somatic hypermutation and selection to both provide effective humoral immunity and to protect against genomic instability and neoplastic ...
Domenick E. Kennedy, Michael K. Okoreeh, Mark Maienschein‐Cline, Junting Ai, Margaret Veselits, Kaitlin C. McLean, Yogesh Dhungana, Hong Wang, Junmin Peng, Hongbo Chi, Malay Mandal, Marcus R. Clark   +11 more
openalex   +3 more sources

Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses [PDF]

Journal of Experimental Medicine, 2018
T follicular helper (Tfh) cells are required to develop germinal center (GC) responses and drive immunoglobulin class switch, affinity maturation, and long-term B cell memory.
Norbert Pardi, Michael J. Hogan, Martin S. Naradikian, Kaela Parkhouse, Derek W. Cain, Letitia D. Jones, M. Anthony Moody, Hans Verkerke, Arpita Myles, Elinor Willis, Celia C. LaBranche, David C. Montefiori, Jenna L Lobby, Kevin O. Saunders, Hua‐Xin Liao, Bette Korber, Laura L. Sutherland, Richard M. Scearce, Peter Hraber, István Tombácz, Hiromi Muramatsu, Houping Ni, Daniel A. Balikov, Zhongxia Li, Barbara L. Mui, Ying K. Tam, Florian Krammer, Katalin Karikó, Patricia Polacino, Laurence C. Eisenlohr, Thomas D. Madden, Michael J. Hope, Mark G. Lewis, Kelly K. Lee, Shiu‐Lok Hu, Scott E. Hensley, Michael P. Cancro, Barton F. Haynes, Drew Weissman   +38 more
openalex   +2 more sources

Dynamic mitochondrial transcription and translation in B cells control germinal center entry and lymphomagenesis

bioRxiv, 2023
Clarke and colleagues show that germinal center B cells have highly dynamic mitochondria, which are regulated by the transcription factor TFAM. TFAM activity is required to promote spatial entry into the germinal center reaction by modulating cellular ...
Yavuz F. Yazicioglu, Eros Marin, S. Galiani, E. Compeer, Ciaran Sandhu, M. Attar, Michael L. Dustin, A. Clarke   +7 more
semanticscholar   +1 more source

Dynamic Regulation of Tfh Selection During the Germinal Center Reaction

Nature, 2021
The germinal centre is a dynamic microenvironment in which B cells that express high-affinity antibody variants produced by somatic hypermutation are selected for clonal expansion by limiting the numbers of T follicular helper cells1,2.
Julia Merkenschlager, Shlomo Finkin, Victor Ramos, Julian Kraft, M. Cipolla, Carla R Nowosad, Harald Hartweger, Wenzhu Zhang, P. D. Olinares, A. Gazumyan, Thiago Y. Oliveira, B. Chait, M. Nussenzweig   +12 more
semanticscholar   +1 more source

Germinal center reactions in tertiary lymphoid structures associate with neoantigen burden, humoral immunity and long-term survivorship in pancreatic cancer

Oncoimmunology, 2021
Pancreatic ductal adenocarcinoma (PDAC) has traditionally been thought of as an immunologically quiescent tumor type presumably because of a relatively low tumor mutational burden (TMB) and poor responses to checkpoint blockade therapy.
Andrew J. Gunderson, V. Rajamanickam, Cynthia Bui, Brady Bernard, J. Pucilowska, C. Ballesteros-Merino, M. Schmidt, K. McCarty, Michael A. Philips, B. Piening, C. Dubay, Terry R. Medler, P. Newell, P. Hansen, E. Tran, Ephraim Tang, C. Bifulco, M. Crittenden, M. Gough, K. Young   +19 more
semanticscholar   +1 more source

Dynamic regulation of B cell Complement Signaling is Integral to Germinal Center Responses

Nature Immunology, 2021
Maturation of B cells within germinal centers (GCs) generates diversified B cell pools and high-affinity B cell antigen receptors (BCRs) for pathogen clearance.
A. Čumpelik, D. Heja, Yuan Hu, G. Varano, F. Ordikhani, Mark P. Roberto, Zhengxiang He, D. Homann, S. Lira, D. Dominguez-Sola, P. Heeger   +10 more
semanticscholar   +1 more source