Results 11 to 20 of about 3,597,774 (337)
Germinal centers and autoantibodies [PDF]
Immunology & Cell Biology, 2020 AbstractPreventing self‐reactive lymphocytes from participating in effector responses is fundamental to maintaining immunological self‐tolerance and circumventing autoimmunity. A range of complementary mechanisms are known to act upon the primary B‐ and T‐cell repertoires to this effect, eliminating or silencing lymphocytes expressing self‐reactive ...
Clara Young +3 more
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Frontiers in Immunology, 2022 The development of a safe and effective vaccine against Yersinia pestis, the causative organism for plague disease, remains an important global health priority.
Darrell R. Galloway +8 more
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Antibody Mediated Intercommunication of Germinal Centers
Cells, 2022 Antibody diversification and selection of B cells occur in dynamic structures called germinal centers (GCs). Passively administered soluble antibodies regulate the GC response by masking the antigen displayed on follicular dendritic cells (FDCs).
Theinmozhi Arulraj +2 more
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YY1 Is Required for Germinal Center B Cell Development. [PDF]
PLoS ONE, 2016 YY1 has been implicated as a master regulator of germinal center B cell development as YY1 binding sites are frequently present in promoters of germinal center-expressed genes. YY1 is known to be important for other stages of B cell development including
Anupam Banerjee +6 more
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Dynamic Regulation of Tfh Selection During the Germinal Center Reaction
Nature, 2021 The germinal centre is a dynamic microenvironment in which B cells that express high-affinity antibody variants produced by somatic hypermutation are selected for clonal expansion by limiting the numbers of T follicular helper cells1,2.
Julia Merkenschlager +12 more
semanticscholar +1 more source
Analysis of immunophenotypic features in hyaline vascular type Castleman disease
Diagnostic Pathology, 2023 Background Studies suggested that the immunophenotype of hyaline vascular type Castleman disease (HVCD) lacked characteristics, which was easy to be confused with other diseases. Methods From January 2010 to June 2022, 17 cases of HVCD were selected from
Yu Chang, Yu Ma, Chen Chang, Wensheng Li
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Oncoimmunology, 2021 Pancreatic ductal adenocarcinoma (PDAC) has traditionally been thought of as an immunologically quiescent tumor type presumably because of a relatively low tumor mutational burden (TMB) and poor responses to checkpoint blockade therapy.
Andrew J. Gunderson +19 more
semanticscholar +1 more source
Dynamic regulation of B cell Complement Signaling is Integral to Germinal Center Responses
Nature Immunology, 2021 Maturation of B cells within germinal centers (GCs) generates diversified B cell pools and high-affinity B cell antigen receptors (BCRs) for pathogen clearance.
A. Čumpelik +10 more
semanticscholar +1 more source
Nature Immunology, 2020 Germinal center B cells (GCBCs) are critical for generating long-lived humoral immunity. How GCBCs meet the energetic challenge of rapid proliferation is poorly understood.
Florian J. Weisel +16 more
semanticscholar +1 more source
Distinctive High Expression of Antiretroviral APOBEC3 Protein in Mouse Germinal Center B Cells
Viruses, 2022 Tissue and subcellular localization and its changes upon cell activation of virus-restricting APOBEC3 at protein levels are important to understanding physiological functions of this cytidine deaminase, but have not been thoroughly analyzed in vivo.
Shota Tsukimoto +8 more
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