Results 11 to 20 of about 181,469 (346)
Germinal Centers without T Cells [PDF]
The Journal of Experimental Medicine, 2000 Germinal centers are critical for affinity maturation of antibody (Ab) responses. This process allows the production of high-efficiency neutralizing Ab that protects against virus infection and bacterial exotoxins. In germinal centers, responding B cells selectively mutate the genes that encode their receptors for antigen.
Yvonne Sunners +8 more
openaire +4 more sources
Recycling probability and dynamical properties of germinal center reactions [PDF]
J. Theor. Biol. 210(3) 2001, 265-285, 2001 We introduce a new model for the dynamics of centroblasts and centrocytes in a germinal center. The model reduces the germinal center reaction to the elements considered as essential and embeds proliferation of centroblasts, point mutations of the ...
Deutsch, Andreas +2 more
core +3 more sources
Co-Evolution of quasispecies: B-cell mutation rates maximize viral error catastrophes [PDF]
Phys. Rev. Lett. 88 (2002) 068104, 2001 Co-evolution of two coupled quasispecies is studied, motivated by the competition between viral evolution and adapting immune response. In this co-adaptive model, besides the classical error catastrophe for high virus mutation rates, a second ...
A. Aigner +29 more
core +2 more sources
Investigating the Mechanism of Germinal Center Shutdown
Frontiers in Immunology, 2022 Germinal centers (GCs) are transient structures where affinity maturation of B cells gives rise to high affinity plasma and memory cells. The mechanism of GC shutdown is unclear, despite being an important phenomenon maintaining immune homeostasis.
Theinmozhi Arulraj +3 more
openaire +4 more sources
Defects in Germinal Center Selection in SLE [PDF]
Frontiers in Immunology, 2015 Germinal centers (GCs) are the primary site at which clonal expansion and affinity maturation of B cells occur. B cells encounter antigen and receive T cell help in the GC light zone (LZ) and then migrate to the dark zone where they proliferate and undergo somatic mutation before cycling back to the LZ for further rounds of selection.
Yong-Rui Zou, Megan Woods, Anne Davidson
openaire +5 more sources
Cells, 2021 Germinal centers (GCs) are transient structures in the secondary lymphoid organs, where B cells undergo affinity maturation to produce high affinity memory and plasma cells.
Theinmozhi Arulraj +2 more
doaj +1 more source
Frontiers in Immunology, 2022 The development of a safe and effective vaccine against Yersinia pestis, the causative organism for plague disease, remains an important global health priority.
Darrell R. Galloway +8 more
doaj +1 more source
Antibody Mediated Intercommunication of Germinal Centers
Cells, 2022 Antibody diversification and selection of B cells occur in dynamic structures called germinal centers (GCs). Passively administered soluble antibodies regulate the GC response by masking the antigen displayed on follicular dendritic cells (FDCs).
Theinmozhi Arulraj +2 more
doaj +1 more source
Analysis of immunophenotypic features in hyaline vascular type Castleman disease
Diagnostic Pathology, 2023 Background Studies suggested that the immunophenotype of hyaline vascular type Castleman disease (HVCD) lacked characteristics, which was easy to be confused with other diseases. Methods From January 2010 to June 2022, 17 cases of HVCD were selected from
Yu Chang, Yu Ma, Chen Chang, Wensheng Li
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Distinctive High Expression of Antiretroviral APOBEC3 Protein in Mouse Germinal Center B Cells
Viruses, 2022 Tissue and subcellular localization and its changes upon cell activation of virus-restricting APOBEC3 at protein levels are important to understanding physiological functions of this cytidine deaminase, but have not been thoroughly analyzed in vivo.
Shota Tsukimoto +8 more
doaj +1 more source