Results 21 to 30 of about 181,469 (346)

Coupled Antigen and BLIMP1 Asymmetric Division With a Large Segregation Between Daughter Cells Recapitulates the Temporal Transition From Memory B Cells to Plasma Cells and a DZ-to-LZ Ratio in the Germinal Center

Frontiers in Immunology, 2021
Memory B cells and antibody-secreting plasma cells are generated within germinal centers during affinity maturation in which B-cell proliferation, selection, differentiation, and self-renewal play important roles.
Elena Merino Tejero, Danial Lashgari, Rodrigo García-Valiente, Jiaojiao He, Jiaojiao He, Philippe A. Robert, Michael Meyer-Hermann, Michael Meyer-Hermann, Jeroen E. J. Guikema, Huub Hoefsloot, Antoine H. C. van Kampen, Antoine H. C. van Kampen   +11 more
doaj   +1 more source

Synchronous Germinal Center Onset Impacts the Efficiency of Antibody Responses

Frontiers in Immunology, 2019
The germinal center reaction is an important target for modulating antibody responses. Antibody production from germinal centers is regulated by a negative feedback mechanism termed antibody feedback.
Theinmozhi Arulraj, Sebastian C. Binder, Sebastian C. Binder, Philippe A. Robert, Michael Meyer-Hermann, Michael Meyer-Hermann, Michael Meyer-Hermann   +6 more
doaj   +1 more source

Amount of antigen, T follicular helper cells and affinity of founder cells shape the diversity of germinal center B cells: A computational study

Frontiers in Immunology, 2023
A variety of B cell clones seed the germinal centers, where a selection stringency expands the fitter clones to generate higher affinity antibodies. However, recent experiments suggest that germinal centers often retain a diverse set of B cell clones ...
Amar K. Garg, Tanmay Mitra, Marta Schips, Arnab Bandyopadhyay, Michael Meyer-Hermann, Michael Meyer-Hermann   +5 more
doaj   +1 more source

Sustained antigen delivery improves germinal center reaction and increases antibody responses in neonatal mice. [PDF]

NPJ Vaccines
Neonates and young infants are known to have limited responses to pediatric vaccines due to reduced germinal center formation. Extended vaccine antigen dosing was previously shown to expand germinal center formation and improve humoral responses in adult
Lotspeich-Cole L, Parvathaneni S, Sakai J, Liu L, Takeda K, Lee RC, Akkoyunlu M.   +6 more
europepmc   +2 more sources

Critical role of SHP2 (PTPN11) signaling in germinal center-derived lymphoma

Haematologica, 2014
Germinal center lymphoma is a heterogeneous human lymphoma entity. Here we report that constitutive activity of SHP2 (PTPN11) and its downstream kinase ERK is essential for the viability of germinal center lymphoma cells and disease progression ...
Xin Jiang, Honggang Guo, Jianguo Wu, Qiang He, Yiqiao Li, Miao Wang, Hongyang Pan, Wande Li, Jinjie Wang, Qingqing Wang, Jing Shen, Yuehai Ke, Ren Zhou   +12 more
doaj   +1 more source

Correlation between Germinal Center Differentiation and Double/Triple Hit Score in the Classification of Diffuse Large B Cell Non-Hodgkin Lymphoma: A Clinicopathological Approach

Asian Pacific Journal of Cancer Care, 2023
Background: Diffuse large B cell lymphoma (DLBCL) is considered the most common type of non-Hodgkin lymphoma. The global incidence of DLBCL has been doubled in the past decades, highlighting the need for more effective treatment regimens.
Israa Sobhy Abdel Razek Okap, Hanan Yehia Ahmed Tayel, Amany Abd El-Bary Abd El-Latif, Dalia Ahmed Mohamed Nafea, Nagwa Abdel Razek Mashali   +4 more
doaj   +1 more source

Germinal Center Optimization Algorithm

International Journal of Computational Intelligence Systems, 2018
Artificial immune systems are metaheuristic algorithms that mimic the adaptive capabilities of the immune system of vertebrates. Since the 1990s, they have become one of the main branches of computer intelligence.
Carlos Villaseñor, Nancy Arana-Daniel, Alma Y. Alanis, Carlos López-Franco, Esteban A. Hernandez-Vargas   +4 more
doaj   +1 more source

PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma

The Journal of Clinical Investigation, 2022
The synthesis of serine from glucose is a key metabolic pathway supporting cellular proliferation in healthy and malignant cells. Despite this, the role that this aspect of metabolism plays in germinal center biology and pathology is not known.
Annalisa D’Avola, Nathalie Legrave, Mylène Tajan, Probir Chakravarty, Ryan L. Shearer, Hamish W. King, Katarina Kluckova, Eric C. Cheung, Andrew J. Clear, Arief S. Gunawan, Lingling Zhang, Louisa K. James, James I. MacRae, John G. Gribben, Dinis P. Calado, Karen H. Vousden, John C. Riches   +16 more
doaj   +1 more source

Spontaneous germinal centers and autoimmunity [PDF]

Autoimmunity, 2017
Germinal centers (GCs) are dynamic microenvironments that form in the secondary lymphoid organs and generate somatically mutated high-affinity antibodies necessary to establish an effective humoral immune response. Tight regulation of GC responses is critical for maintaining self-tolerance.
Stephanie L. Schell, Phillip P. Domeier, Zia Ur Rahman   +2 more
openaire   +4 more sources

Treg Cells and CTLA-4: The Ball and Chain of the Germinal Center Response [PDF]

, 2014
The mechanism by which regulatory T cells control the germinal center response is unknown. In this issue of Immunity, Wing et al. (2014) and Sage et al. (2014) demonstrate that CTLA-4 is a critical effector molecule used by regulatory T cells to control ...
Denton, Alice E., Linterman, Michelle A.   +1 more
core   +1 more source