Results 21 to 30 of about 3,782,491 (387)

Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis

Nature Immunology, 2020
Germinal center B cells (GCBCs) are critical for generating long-lived humoral immunity. How GCBCs meet the energetic challenge of rapid proliferation is poorly understood.
Florian J. Weisel, S. Mullett, Rebecca A. Elsner, Ashley V Menk, N. Trivedi, W. Luo, Daniel J. Wikenheiser, William F. Hawse, M. Chikina, S. Smita, Laura Conter, Stephen M. Joachim, S. Wendell, M. Jurczak, T. Winkler, Greg M. Delgoffe, M. Shlomchik   +16 more
semanticscholar   +1 more source

Single-cell analysis of germinal-center B cells informs on lymphoma cell of origin and outcome

Journal of Experimental Medicine, 2020
Single-cell transcriptomic analysis of germinal center B cells identifies multiple linked populations, most of which represent cell of origin of lymphomas.
A. Holmes, C. Corinaldesi, Qiong Shen, Rahul Kumar, Nicolò Compagno, Zhong Wang, M. Nitzan, E. Grunstein, L. Pasqualucci, R. Dalla-Favera, K. Basso   +10 more
semanticscholar   +1 more source

Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease: the salivary glands of patients with Sjögren's syndrome [PDF]

, 1998
Structures resembling germinal centers are seen in the salivary glands of patients with Sjögren's syndrome, but it is not known whether the microenvironment of these cell clusters is sufficient for the induction of a germinal center response.
Berek, C., Hiepe, F., Hummel, M., Steinhauser, G., Stott, D.I.   +4 more
core   +2 more sources

Critical role of SHP2 (PTPN11) signaling in germinal center-derived lymphoma

Haematologica, 2014
Germinal center lymphoma is a heterogeneous human lymphoma entity. Here we report that constitutive activity of SHP2 (PTPN11) and its downstream kinase ERK is essential for the viability of germinal center lymphoma cells and disease progression ...
Xin Jiang, Honggang Guo, Jianguo Wu, Qiang He, Yiqiao Li, Miao Wang, Hongyang Pan, Wande Li, Jinjie Wang, Qingqing Wang, Jing Shen, Yuehai Ke, Ren Zhou   +12 more
doaj   +1 more source

Randomized Phase III Trial of Ibrutinib and Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Non-Germinal Center B-Cell Diffuse Large B-Cell Lymphoma.

Journal of Clinical Oncology, 2019
PURPOSE Ibrutinib has shown activity in non-germinal center B-cell diffuse large B-cell lymphoma (DLBCL). This double-blind phase III study evaluated ibrutinib and rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in ...
A. Younes, L. Sehn, P. Johnson, P. Zinzani, X. Hong, Jun Zhu, C. Patti, D. Belada, O. Samoilova, C. Suh, S. Leppä, S. Rai, M. Turgut, W. Jurczak, Matthew Cheung, R. Gurion, S. Yeh, A. López‐Hernandez, U. Dührsen, C. Thieblemont, C. Chiattone, S. Balasubramanian, J. Carey, Grace Liu, S. Shreeve, Steven Sun, S. Zhuang, J. Vermeulen, L. Staudt, W. Wilson   +29 more
semanticscholar   +1 more source

Remodeling of light and dark zone follicular dendritic cells governs germinal center responses

Nature Immunology, 2020
Efficient generation of germinal center (GC) responses requires directed movement of B cells between distinct microenvironments underpinned by specialized B cell–interacting reticular cells (BRCs).
N. Pikor, U. Mörbe, Mechthild Lütge, C. Gil-Cruz, C. Perez-Shibayama, M. Novkovic, Hung-Wei Cheng, C. Nombela-Arrieta, T. Nagasawa, M. Linterman, L. Onder, B. Ludewig   +11 more
semanticscholar   +1 more source

Germinal Center Optimization Algorithm

International Journal of Computational Intelligence Systems, 2018
Artificial immune systems are metaheuristic algorithms that mimic the adaptive capabilities of the immune system of vertebrates. Since the 1990s, they have become one of the main branches of computer intelligence.
Carlos Villaseñor, Nancy Arana-Daniel, Alma Y. Alanis, Carlos López-Franco, Esteban A. Hernandez-Vargas   +4 more
doaj   +1 more source

Coupled Antigen and BLIMP1 Asymmetric Division With a Large Segregation Between Daughter Cells Recapitulates the Temporal Transition From Memory B Cells to Plasma Cells and a DZ-to-LZ Ratio in the Germinal Center

Frontiers in Immunology, 2021
Memory B cells and antibody-secreting plasma cells are generated within germinal centers during affinity maturation in which B-cell proliferation, selection, differentiation, and self-renewal play important roles.
Elena Merino Tejero, Danial Lashgari, Rodrigo García-Valiente, Jiaojiao He, Jiaojiao He, Philippe A. Robert, Michael Meyer-Hermann, Michael Meyer-Hermann, Jeroen E. J. Guikema, Huub Hoefsloot, Antoine H. C. van Kampen, Antoine H. C. van Kampen   +11 more
doaj   +1 more source

Germinal centers and autoantibodies [PDF]

Immunology & Cell Biology, 2020
AbstractPreventing self‐reactive lymphocytes from participating in effector responses is fundamental to maintaining immunological self‐tolerance and circumventing autoimmunity. A range of complementary mechanisms are known to act upon the primary B‐ and T‐cell repertoires to this effect, eliminating or silencing lymphocytes expressing self‐reactive ...
Clara, Young, Robert, Brink
openaire   +2 more sources

Artery tertiary lymphoid organs control multi-layered territorialized atherosclerosis B cell responses in aged ApoE-/- mice [PDF]

, 2016
Objective: Explore aorta B cell immunity in aged ApoE-/- mice. Approach and Results: Transcript maps, FACS, immunofluorescence analyses, cell transfers, and Ig-ELISPOT assays showed multi-layered atherosclerosis B cell responses in artery tertiary ...
Andreas J.R. Habenicht, Changjun Yin, Christian Weber, Coleen A. McNamara, Desheng Hu, Gianluca Grassia, Kulkarni U, Li Peng, Michael Beer, Pasquale Maffia, Prasad Srikakulapu, Rudolf A. Manz, Sai Vineela Bontha, Sarajo K. Mohanta   +13 more
core   +1 more source