Results 21 to 30 of about 3,597,774 (337)

Single-cell analysis of germinal-center B cells informs on lymphoma cell of origin and outcome

Journal of Experimental Medicine, 2020
Single-cell transcriptomic analysis of germinal center B cells identifies multiple linked populations, most of which represent cell of origin of lymphomas.
A. Holmes, C. Corinaldesi, Qiong Shen, Rahul Kumar, Nicolò Compagno, Zhong Wang, M. Nitzan, E. Grunstein, L. Pasqualucci, R. Dalla-Favera, K. Basso   +10 more
semanticscholar   +1 more source

Remodeling of light and dark zone follicular dendritic cells governs germinal center responses

Nature Immunology, 2020
Efficient generation of germinal center (GC) responses requires directed movement of B cells between distinct microenvironments underpinned by specialized B cell–interacting reticular cells (BRCs).
N. Pikor, U. Mörbe, Mechthild Lütge, C. Gil-Cruz, C. Perez-Shibayama, M. Novkovic, Hung-Wei Cheng, C. Nombela-Arrieta, T. Nagasawa, M. Linterman, L. Onder, B. Ludewig   +11 more
semanticscholar   +1 more source

Acute SIV infection in sooty mangabey monkeys is characterized by rapid virus clearance from lymph nodes and absence of productive infection in germinal centers. [PDF]

PLoS ONE, 2013
Lymphoid tissue immunopathology is a characteristic feature of chronic HIV/SIV infection in AIDS-susceptible species, but is absent in SIV-infected natural hosts.
Amanda J Martinot, Mareike Meythaler, Lu-Ann Pozzi, Karen Dalecki Boisvert, Heather Knight, Dennis Walsh, Susan Westmoreland, Daniel C Anderson, Amitinder Kaur, Shawn P O'Neil   +9 more
doaj   +1 more source

Coupled Antigen and BLIMP1 Asymmetric Division With a Large Segregation Between Daughter Cells Recapitulates the Temporal Transition From Memory B Cells to Plasma Cells and a DZ-to-LZ Ratio in the Germinal Center

Frontiers in Immunology, 2021
Memory B cells and antibody-secreting plasma cells are generated within germinal centers during affinity maturation in which B-cell proliferation, selection, differentiation, and self-renewal play important roles.
Elena Merino Tejero, Danial Lashgari, Rodrigo García-Valiente, Jiaojiao He, Jiaojiao He, Philippe A. Robert, Michael Meyer-Hermann, Michael Meyer-Hermann, Jeroen E. J. Guikema, Huub Hoefsloot, Antoine H. C. van Kampen, Antoine H. C. van Kampen   +11 more
doaj   +1 more source

Synchronous Germinal Center Onset Impacts the Efficiency of Antibody Responses

Frontiers in Immunology, 2019
The germinal center reaction is an important target for modulating antibody responses. Antibody production from germinal centers is regulated by a negative feedback mechanism termed antibody feedback.
Theinmozhi Arulraj, Sebastian C. Binder, Sebastian C. Binder, Philippe A. Robert, Michael Meyer-Hermann, Michael Meyer-Hermann, Michael Meyer-Hermann   +6 more
doaj   +1 more source

Amount of antigen, T follicular helper cells and affinity of founder cells shape the diversity of germinal center B cells: A computational study

Frontiers in Immunology, 2023
A variety of B cell clones seed the germinal centers, where a selection stringency expands the fitter clones to generate higher affinity antibodies. However, recent experiments suggest that germinal centers often retain a diverse set of B cell clones ...
Amar K. Garg, Tanmay Mitra, Marta Schips, Arnab Bandyopadhyay, Michael Meyer-Hermann, Michael Meyer-Hermann   +5 more
doaj   +1 more source

Critical role of SHP2 (PTPN11) signaling in germinal center-derived lymphoma

Haematologica, 2014
Germinal center lymphoma is a heterogeneous human lymphoma entity. Here we report that constitutive activity of SHP2 (PTPN11) and its downstream kinase ERK is essential for the viability of germinal center lymphoma cells and disease progression ...
Xin Jiang, Honggang Guo, Jianguo Wu, Qiang He, Yiqiao Li, Miao Wang, Hongyang Pan, Wande Li, Jinjie Wang, Qingqing Wang, Jing Shen, Yuehai Ke, Ren Zhou   +12 more
doaj   +1 more source

Correlation between Germinal Center Differentiation and Double/Triple Hit Score in the Classification of Diffuse Large B Cell Non-Hodgkin Lymphoma: A Clinicopathological Approach

Asian Pacific Journal of Cancer Care, 2023
Background: Diffuse large B cell lymphoma (DLBCL) is considered the most common type of non-Hodgkin lymphoma. The global incidence of DLBCL has been doubled in the past decades, highlighting the need for more effective treatment regimens.
Israa Sobhy Abdel Razek Okap, Hanan Yehia Ahmed Tayel, Amany Abd El-Bary Abd El-Latif, Dalia Ahmed Mohamed Nafea, Nagwa Abdel Razek Mashali   +4 more
doaj   +1 more source

Randomized Phase III Trial of Ibrutinib and Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Non-Germinal Center B-Cell Diffuse Large B-Cell Lymphoma.

Journal of Clinical Oncology, 2019
PURPOSE Ibrutinib has shown activity in non-germinal center B-cell diffuse large B-cell lymphoma (DLBCL). This double-blind phase III study evaluated ibrutinib and rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in ...
A. Younes, L. Sehn, P. Johnson, P. Zinzani, X. Hong, Jun Zhu, C. Patti, D. Belada, O. Samoilova, C. Suh, S. Leppä, S. Rai, M. Turgut, W. Jurczak, Matthew Cheung, R. Gurion, S. Yeh, A. López‐Hernandez, U. Dührsen, C. Thieblemont, C. Chiattone, S. Balasubramanian, J. Carey, Grace Liu, S. Shreeve, Steven Sun, S. Zhuang, J. Vermeulen, L. Staudt, W. Wilson   +29 more
semanticscholar   +1 more source

Synaptic Interactions in Germinal Centers [PDF]

Frontiers in Immunology, 2018
The germinal center (GC) is a complex, highly dynamic microanatomical niche that allows the generation of high-affinity antibody-producing plasma cells and memory B cells. These cells constitute the basis of long-lived highly protective antibody responses.
Papa, Ilenia, Garcia De Vinuesa, Maria Carola   +1 more
openaire   +5 more sources