Results 31 to 40 of about 3,584,858 (336)
PURPOSE Ibrutinib has shown activity in non-germinal center B-cell diffuse large B-cell lymphoma (DLBCL). This double-blind phase III study evaluated ibrutinib and rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in ...
A. Younes+29 more
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T follicular helper cells in germinal center B cell selection and lymphomagenesis
Germinal centers (GCs) are confined anatomic regions where rapidly proliferating B cells undergo somatic mutation and selection and eventual differentiation into memory B cells or long‐lived plasma cells.
M. Mintz, J. Cyster
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The Biology of the Germinal Center [PDF]
The immune system requires the production of high affinity antibodies of different subclasses to accomplish its many effector functions. Specific steps in B-cell ontogeny that occur within germinal centers of secondary lymphoid organs create much of the diversity in the immune system.
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Spontaneous germinal centers and autoimmunity [PDF]
Germinal centers (GCs) are dynamic microenvironments that form in the secondary lymphoid organs and generate somatically mutated high-affinity antibodies necessary to establish an effective humoral immune response. Tight regulation of GC responses is critical for maintaining self-tolerance.
Stephanie L. Schell+2 more
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Deficiency of Tfh Cells and Germinal Center in Deceased COVID-19 Patients
The COVID-19 pandemic caused by SARS-CoV2 is characterized by a remarkable variation in clinical severity ranging from a mild illness to a fatal multi-organ disease.
Y. Duan+13 more
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Stress is a non specific respone of body if the deman of body increase cause a stressor. Stress will increase sympathetic activity with releasing apinephrine and cortisol.
Siti Arifah, Okti Sri Purwanti
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Inoue et al. show that a small population of germinal center–derived CD38intBcl6hi/intEfnb1+ cells with lower mTORC1 activity favors a memory B cell fate.
Takeshi Inoue+10 more
semanticscholar +1 more source
Enhancers are regulatory regions of DNA, which play a key role in cell-type specific differentiation and development. Most active enhancers are transcribed into enhancer RNA (eRNA) that can regulate transcription of target genes by means of in cis as ...
Sara Napoli+17 more
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Protein-based, self-assembling nanoparticles elicit superior immunity compared with soluble protein vaccines, but the immune mechanisms underpinning this effect remain poorly defined.
Hannah G. Kelly+12 more
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Textbook Germinal Centers? [PDF]
AbstractModels for the development and function of germinal centers (GCs) have been so widely discussed in the original literature that they now appear in immunology textbooks. Unfortunately, many of the tenets of these models have not yet been subjected to adequate experimental scrutiny.
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