Results 31 to 40 of about 3,584,858 (336)

Randomized Phase III Trial of Ibrutinib and Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Non-Germinal Center B-Cell Diffuse Large B-Cell Lymphoma.

open access: yesJournal of Clinical Oncology, 2019
PURPOSE Ibrutinib has shown activity in non-germinal center B-cell diffuse large B-cell lymphoma (DLBCL). This double-blind phase III study evaluated ibrutinib and rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in ...
A. Younes   +29 more
semanticscholar   +1 more source

T follicular helper cells in germinal center B cell selection and lymphomagenesis

open access: yesImmunological Reviews, 2020
Germinal centers (GCs) are confined anatomic regions where rapidly proliferating B cells undergo somatic mutation and selection and eventual differentiation into memory B cells or long‐lived plasma cells.
M. Mintz, J. Cyster
semanticscholar   +1 more source

The Biology of the Germinal Center [PDF]

open access: yesHematology, 2007
The immune system requires the production of high affinity antibodies of different subclasses to accomplish its many effector functions. Specific steps in B-cell ontogeny that occur within germinal centers of secondary lymphoid organs create much of the diversity in the immune system.
openaire   +3 more sources

Spontaneous germinal centers and autoimmunity [PDF]

open access: yesAutoimmunity, 2017
Germinal centers (GCs) are dynamic microenvironments that form in the secondary lymphoid organs and generate somatically mutated high-affinity antibodies necessary to establish an effective humoral immune response. Tight regulation of GC responses is critical for maintaining self-tolerance.
Stephanie L. Schell   +2 more
openaire   +4 more sources

Deficiency of Tfh Cells and Germinal Center in Deceased COVID-19 Patients

open access: yesCurrent Medical Science, 2020
The COVID-19 pandemic caused by SARS-CoV2 is characterized by a remarkable variation in clinical severity ranging from a mild illness to a fatal multi-organ disease.
Y. Duan   +13 more
semanticscholar   +1 more source

PENGARUH PEMBERIAN EPINEPRIN DAN HIDROKORTISON TERHADAP JUMLAH DAN DIAMETER GERMINAL CENTER KELENJAR GETAH BENING TIKUS PUTIH JANTAN WISTAR

open access: yesJurnal Berita Ilmu Keperawatan, 2008
Stress is a non specific respone of body if the deman of body increase cause a stressor. Stress will increase sympathetic activity with releasing apinephrine and cortisol.
Siti Arifah, Okti Sri Purwanti
doaj   +1 more source

Exit from germinal center to become quiescent memory B cells depends on metabolic reprograming and provision of a survival signal

open access: yesJournal of Experimental Medicine, 2020
Inoue et al. show that a small population of germinal center–derived CD38intBcl6hi/intEfnb1+ cells with lower mTORC1 activity favors a memory B cell fate.
Takeshi Inoue   +10 more
semanticscholar   +1 more source

Characterization of GECPAR, a noncoding RNA that regulates the transcriptional program of diffuse large B-cell lymphoma

open access: yesHaematologica, 2021
Enhancers are regulatory regions of DNA, which play a key role in cell-type specific differentiation and development. Most active enhancers are transcribed into enhancer RNA (eRNA) that can regulate transcription of target genes by means of in cis as ...
Sara Napoli   +17 more
doaj   +1 more source

Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation.

open access: yesJCI Insight, 2020
Protein-based, self-assembling nanoparticles elicit superior immunity compared with soluble protein vaccines, but the immune mechanisms underpinning this effect remain poorly defined.
Hannah G. Kelly   +12 more
semanticscholar   +1 more source

Textbook Germinal Centers? [PDF]

open access: yesThe Journal of Immunology, 2004
AbstractModels for the development and function of germinal centers (GCs) have been so widely discussed in the original literature that they now appear in immunology textbooks. Unfortunately, many of the tenets of these models have not yet been subjected to adequate experimental scrutiny.
openaire   +2 more sources

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