Results 31 to 40 of about 3,782,491 (387)

Amount of antigen, T follicular helper cells and affinity of founder cells shape the diversity of germinal center B cells: A computational study

Frontiers in Immunology, 2023
A variety of B cell clones seed the germinal centers, where a selection stringency expands the fitter clones to generate higher affinity antibodies. However, recent experiments suggest that germinal centers often retain a diverse set of B cell clones ...
Amar K. Garg, Tanmay Mitra, Marta Schips, Arnab Bandyopadhyay, Michael Meyer-Hermann, Michael Meyer-Hermann   +5 more
doaj   +1 more source

Textbook Germinal Centers? [PDF]

The Journal of Immunology, 2004
AbstractModels for the development and function of germinal centers (GCs) have been so widely discussed in the original literature that they now appear in immunology textbooks. Unfortunately, many of the tenets of these models have not yet been subjected to adequate experimental scrutiny.
openaire   +2 more sources

Expression of thyroglobulin on follicular dendritic cells of thyroid mucosa-associated lymphoid tissue (MALT) lymphoma [PDF]

, 2009
Reportedly, thyroid mucosa-associated lymphoid tissue (MALT) lymphoma is closely associated with Hashimoto's thyroiditis. However, it remains unknown which antigen is closely associated with thyroid MALT lymphoma.
Akagi, Tadaatsu, Kobayashi, Keita, Mannami, Tomohiko, Miyake, Takayoshi, Munemasa, Mitsuru, Sakugawa, Sumie Takase, Shinagawa, Katsuji, Tanimoto, Mitsune, Yoshino, Tadashi   +8 more
core   +1 more source

T follicular helper cells in germinal center B cell selection and lymphomagenesis

Immunological Reviews, 2020
Germinal centers (GCs) are confined anatomic regions where rapidly proliferating B cells undergo somatic mutation and selection and eventual differentiation into memory B cells or long‐lived plasma cells.
M. Mintz, J. Cyster
semanticscholar   +1 more source

Correlation between Germinal Center Differentiation and Double/Triple Hit Score in the Classification of Diffuse Large B Cell Non-Hodgkin Lymphoma: A Clinicopathological Approach

Asian Pacific Journal of Cancer Care, 2023
Background: Diffuse large B cell lymphoma (DLBCL) is considered the most common type of non-Hodgkin lymphoma. The global incidence of DLBCL has been doubled in the past decades, highlighting the need for more effective treatment regimens.
Israa Sobhy Abdel Razek Okap, Hanan Yehia Ahmed Tayel, Amany Abd El-Bary Abd El-Latif, Dalia Ahmed Mohamed Nafea, Nagwa Abdel Razek Mashali   +4 more
doaj   +1 more source

GLUT1 expression patterns in different Hodgkin lymphoma subtypes and progressively transformed germinal centers [PDF]

, 2012
Background: Increased glycolytic activity is a hallmark of cancer, allowing staging and restaging with 18F-fluorodeoxyglucose-positron-emission-tomography (PET).
Agostinelli, Claudio, Bergmann, Lothar, Diener, Jürgen, Döring, Claudia, Fanti, Stefano, Gallamini, Andrea, Hansmann, Martin-Leo, Hartmann, Sylvia, Pileri, Stefano, Zinzani, Pier Luigi   +9 more
core   +1 more source

Double-Hit Gene Expression Signature Defines a Distinct Subgroup of Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma.

Journal of Clinical Oncology, 2019
PURPOSE High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH) has a poor outcome after standard chemoimmunotherapy. We sought to understand the biologic underpinnings of HGBL-DH/TH with BCL2 rearrangements (HGBL-DH/TH- BCL2)
Daisuke Ennishi, A. Jiang, M. Boyle, B. Collinge, B. Grande, S. Ben-Neriah, C. Rushton, Jeffrey M. Tang, N. Thomas, G. Slack, P. Farinha, K. Takata, T. Miyata‐Takata, J. Craig, A. Mottok, B. Meissner, Saeed Saberi, Ali Bashashati, D. Villa, K. Savage, L. Sehn, R. Kridel, A. Mungall, M. Marra, Sohrab P. Shah, C. Steidl, J. Connors, R. Gascoyne, Ryan D. Morin, D. Scott   +29 more
semanticscholar   +1 more source

Optimality of mutation and selection in germinal centers [PDF]

, 2010
The population dynamics theory of B cells in a typical germinal center could play an important role in revealing how affinity maturation is achieved. However, the existing models encountered some conflicts with experiments. To resolve these conflicts, we
Arup K. Chakraborty, BP O'Connor, C Berek, C Berek, C Kesmir, C Kocks, CD Allen, CD Allen, D Iber, D Paus, E Brunet, Eugene I. Shakhnovich, F Celada, F Coffey, FD Batista, FG Kroese, G Shahaf, GJ Wedemayer, H Torigoe, HD Ulrich, IC MacLennan, IM Rouzine, IM Rouzine, J Jacob, J Jacob, J Jacob, J Sharon, J Sharon, J Zhang, Jingshan Zhang, K Rajewsky, KG Smith, LS Tsimring, M Meyer-Hermann, M Oprea, M Or-Guil, M Shannon, M Siekevitz, M Ziegner, MD Kumar, MD Radmacher, ME Meyer-Hermann, MG Hanna Jr, MG McHeyzer-Williams, MJ Shlomchik, MM Desai, MS Neuberger, MW Deem, PL Yang, R Kuppers, S Han, SH Kleinstein, TA Schwickert, TB Kepler, TB Kepler, V Pascual, YJ Liu   +56 more
core   +4 more sources

Transfer of extracellular vesicle‐microRNA controls germinal center reaction and antibody production

EMBO Reports, 2020
Intercellular communication orchestrates effective immune responses against disease‐causing agents. Extracellular vesicles (EVs) are potent mediators of cell–cell communication.
Lola Fernández-Messina, Ana Rodríguez-Galán, V. G. de Yébenes, Cristina Gutiérrez-Vázquez, S. Tenreiro, M. Seabra, A. Ramiro, F. Sánchez‐Madrid   +7 more
semanticscholar   +1 more source

PENGARUH PEMBERIAN EPINEPRIN DAN HIDROKORTISON TERHADAP JUMLAH DAN DIAMETER GERMINAL CENTER KELENJAR GETAH BENING TIKUS PUTIH JANTAN WISTAR

Jurnal Berita Ilmu Keperawatan, 2008
Stress is a non specific respone of body if the deman of body increase cause a stressor. Stress will increase sympathetic activity with releasing apinephrine and cortisol.
Siti Arifah, Okti Sri Purwanti
doaj   +1 more source