Results 41 to 50 of about 3,782,491 (387)

Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation.

JCI Insight, 2020
Protein-based, self-assembling nanoparticles elicit superior immunity compared with soluble protein vaccines, but the immune mechanisms underpinning this effect remain poorly defined.
Hannah G. Kelly, Hyon-Xhi Tan, J. Juno, R. Esterbauer, Yi Ju, Wenbo Jiang, Verena C. Wimmer, Brigette C. Duckworth, J. Groom, F. Caruso, M. Kanekiyo, S. Kent, A. Wheatley   +12 more
semanticscholar   +1 more source

Is now the time for molecular driven therapy for diffuse large B-cell lymphoma? [PDF]

, 2017
INTRODUCTION: Recent genetic and molecular discoveries regarding alterations in diffuse large B-cell lymphoma (DLBCL) deeply changed the approach to this lymphoproliferative disorder.
Ansuinelli, Michela, DE ANGELIS, Federico, DI ROCCO, Alice, Foa, Roberto, Martelli, Maurizio   +4 more
core   +1 more source

Deficiency of Tfh Cells and Germinal Center in Deceased COVID-19 Patients

Current Medical Science, 2020
The COVID-19 pandemic caused by SARS-CoV2 is characterized by a remarkable variation in clinical severity ranging from a mild illness to a fatal multi-organ disease.
Y. Duan, M. Xia, L. Ren, Yan-fang Zhang, Q. Ao, San-peng Xu, D. Kuang, Qian Liu, Bing Yan, Yi-wu Zhou, Q. Chu, Liang Liu, Xiang-Ping Yang, Guo-ping Wang   +13 more
semanticscholar   +1 more source

γδ T cells affect IL-4 production and B-cell tolerance [PDF]

, 2014
γδ T cells can influence specific antibody responses. Here, we report that mice deficient in individual γδ T-cell subsets have altered levels of serum antibodies, including all major subclasses, sometimes regardless of the presence of αβ T cells.
Andrew Getahun, Cohen, Finkelman, Gerber, Greg A. Kirchenbaum, Hidaka, Hirose, Hua Huang, Izui, John C. Cambier, Koichi Ikuta, Kubo, Lawrence J. Wysocki, M. Kemal Aydintug, Rebecca L. O’Brien, Ryan A. Heiser, Simon R. Carding, Sperling, Sunaga, Tamara L. Casper, Thiago O. Detanico, Willi K. Born, Yafei Huang   +22 more
core   +1 more source

A Theory of Germinal Center B Cell Selection, Division, and Exit

Cell Reports, 2012
High-affinity antibodies are generated in germinal centers in a process involving mutation and selection of B cells. Information processing in germinal center reactions has been investigated in a number of recent experiments.
Michael Meyer-Hermann, Elodie Mohr, Nadége Pelletier, Yang Zhang, Gabriel D. Victora, Kai-Michael Toellner   +5 more
doaj   +1 more source

Characterization of GECPAR, a noncoding RNA that regulates the transcriptional program of diffuse large B-cell lymphoma

Haematologica, 2021
Enhancers are regulatory regions of DNA, which play a key role in cell-type specific differentiation and development. Most active enhancers are transcribed into enhancer RNA (eRNA) that can regulate transcription of target genes by means of in cis as ...
Sara Napoli, Luciano Cascione, Andrea Rinaldi, Filippo Spriano, Francesca Guidetti, Fangwen Zhang, Maria Teresa Cacciapuoti, Afua Adjeiwaa Mensah, Giulio Sartori, Nicolas Munz, Mattia Forcato, Silvio Bicciato, Annalisa Chiappella, Paola Ghione, Olivier Elemento, Leandro Cerchietti, Giorgio Inghirami, Francesco Bertoni   +17 more
doaj   +1 more source

CCCTC-binding factor locks premature IgH germline transcription and restrains class switch recombination [PDF]

, 2017
In response to antigenic stimulation B cells undergo class switch recombination (CSR) at the immunoglobulin heavy chain (IgH) to replace the primary IgM/IgD isotypes by IgG, IgE, or IgA.
Marina-Zárate, Ester, Pérez-García, Arantxa, Ramiro, Almudena R.   +2 more
core   +3 more sources

Type I interferon induces CXCL13 to support ectopic germinal center formation

Journal of Experimental Medicine, 2019
Ectopic lymphoid structures form in a wide range of inflammatory conditions, including infection, autoimmune disease, and cancer. In the context of infection, this response can be beneficial for the host: influenza A virus infection–induced pulmonary ...
A. Denton, S. Innocentin, E. J. Carr, Barry M. Bradford, Fanny Lafouresse, N. Mabbott, U. Mörbe, B. Ludewig, J. Groom, K. Good-Jacobson, M. Linterman   +10 more
semanticscholar   +1 more source

A Cancer and Leukemia Group B multi-center study of DA-EPOCH-rituximab in untreated diffuse large B-cell lymphoma with analysis of outcome by molecular subtype

Haematologica, 2012
Background A phase II trial of dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin and rituximab (DA-EPOCH-R) from the National Cancer Institute showed promising activity in untreated diffuse large B-cell lymphoma.
Wyndham H. Wilson, Sin-Ho Jung, Pierluigi Porcu, David Hurd, Jeffrey Johnson, S. Eric Martin, Myron Czuczman, Raymond Lai, Jonathan Said, Amy Chadburn, Dan Jones, Kieron Dunleavy, George Canellos, Andrew D. Zelenetz, Bruce D. Cheson, Eric D. Hsi   +15 more
doaj   +1 more source

Regulation of B cell fate by chronic activity of the IgE B cell receptor. [PDF]

, 2016
IgE can trigger potent allergic responses, yet the mechanisms regulating IgE production are poorly understood. Here we reveal that IgE+ B cells are constrained by chronic activity of the IgE B cell receptor (BCR).
Allen, Christopher DC, Chen, Xiangjun, Liu, Wanli, Robinson, Marcus J, Smith, Geoffrey A, Taunton, Jack, Yang, Zhiyong   +6 more
core   +1 more source