microRNA Fine-Tuning of the Germinal Center Response
Frontiers in Immunology, 2021 Germinal centers (GCs) are complex multicellular structures in which antigen-specific B cells undergo the molecular remodeling that enables the generation of high-affinity antibodies and the differentiation programs that lead to the generation of plasma ...
Teresa Fuertes +3 more
doaj +1 more source
Generation of antigen-specific memory CD4 T cells by heterologous immunization enhances the magnitude of the germinal center response upon influenza infection. [PDF]
PLoS PathogCurrent influenza vaccine strategies have yet to overcome significant obstacles, including rapid antigenic drift of seasonal influenza viruses, in generating efficacious long-term humoral immunity.
Sircy LM +10 more
europepmc +2 more sources
AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells. [PDF]
PLoS ONE, 2012 Upon activation, B cells divide, form a germinal center, and express the activation induced deaminase (AID), an enzyme that triggers somatic hypermutation of the variable regions of immunoglobulin (Ig) loci. Recent evidence indicates that at least 25% of
Hillary Selle Gramlich +2 more
doaj +1 more source
Examination of Some Nut Traits and Release From Dormancy Along With Germination Capacity in Some Bitter Almond Genotypes [PDF]
, 2023 This study was conducted at College of Agricultural Engineering Sciences, University of Sulaimani, Kurdistan Region-Iraq so as to investigate some nut traits in 10 bitter almond genotypes, capacity of them to release from dormancy and finally germination ability.
arxiv +1 more source
Smad1 Expression in Follicular Lymphoma [PDF]
Journal of Pathology and Translational Medicine, 2015 Background: Follicular lymphomas present with various immunohistologic patterns. The immunohistochemical markers used in the diagnosis of follicular lymphoma show variable degrees of sensitivity and specificity, and thus, additional germinal center ...
Jai Hyang Go
doaj +1 more source
The germinal center antibody response in health and disease [version 1; referees: 2 approved]
F1000Research, 2016 The germinal center response is the delayed but sustained phase of the antibody response that is responsible for producing high-affinity antibodies of the IgG, IgA and/or IgE isotypes. B cells in the germinal center undergo re-iterative cycles of somatic
Anthony L. DeFranco
doaj +1 more source
CCCTC-binding factor locks premature IgH germline transcription and restrains class switch recombination [PDF]
, 2017 In response to antigenic stimulation B cells undergo class switch recombination (CSR) at the immunoglobulin heavy chain (IgH) to replace the primary IgM/IgD isotypes by IgG, IgE, or IgA.
Marina-Zárate, Ester +2 more
core +3 more sources
Journal of Immunology Research, 2020 An increased level of microbial translocation has been observed in HIV-infected individuals. The host response to microbial translocation is compromised in HIV-infected progressors but remains unknown in HIV-infected long-term nonprogressors (LTNPs).
Lei Huang +4 more
doaj +1 more source
Comparison between the effect of activated waters on lentil seed germination using various plasma reactors and hydrogen injection system [PDF]
arXiv, 2023 As a threat to meeting the global demand for food created by the continued growth of the population, different methods are being applied to enhance seed germination and plant growth. This study investigates the effect of hydrogen-riched water (HRW), plasma-activated water (PAW) and their combination on the seed germination of lentils.
arxiv
Dendritic cells steering antigen and leukocyte traffic in lymph nodes
FEBS Letters, EarlyView.Dendritic cells are key players in the activation of T cells and their commitment to effector function. In this In a Nutshell Review, we will discuss how dendritic cells guide the trafficking of antigen and leukocytes in the lymph node, thus influencing T‐cell activation processes. Dendritic cells (DCs) play a central role in initiating and shaping the
Enrico Dotta +3 more
wiley +1 more source