Results 41 to 50 of about 3,597,774 (337)

A Theory of Germinal Center B Cell Selection, Division, and Exit

Cell Reports, 2012
High-affinity antibodies are generated in germinal centers in a process involving mutation and selection of B cells. Information processing in germinal center reactions has been investigated in a number of recent experiments.
Michael Meyer-Hermann, Elodie Mohr, Nadége Pelletier, Yang Zhang, Gabriel D. Victora, Kai-Michael Toellner   +5 more
doaj   +1 more source

microRNA Fine-Tuning of the Germinal Center Response

Frontiers in Immunology, 2021
Germinal centers (GCs) are complex multicellular structures in which antigen-specific B cells undergo the molecular remodeling that enables the generation of high-affinity antibodies and the differentiation programs that lead to the generation of plasma ...
Teresa Fuertes, Irene Salgado, Virginia G. de Yébenes, Virginia G. de Yébenes   +3 more
doaj   +1 more source

A Cancer and Leukemia Group B multi-center study of DA-EPOCH-rituximab in untreated diffuse large B-cell lymphoma with analysis of outcome by molecular subtype

Haematologica, 2012
Background A phase II trial of dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin and rituximab (DA-EPOCH-R) from the National Cancer Institute showed promising activity in untreated diffuse large B-cell lymphoma.
Wyndham H. Wilson, Sin-Ho Jung, Pierluigi Porcu, David Hurd, Jeffrey Johnson, S. Eric Martin, Myron Czuczman, Raymond Lai, Jonathan Said, Amy Chadburn, Dan Jones, Kieron Dunleavy, George Canellos, Andrew D. Zelenetz, Bruce D. Cheson, Eric D. Hsi   +15 more
doaj   +1 more source

Investigating the Mechanism of Germinal Center Shutdown

Frontiers in Immunology, 2022
Germinal centers (GCs) are transient structures where affinity maturation of B cells gives rise to high affinity plasma and memory cells. The mechanism of GC shutdown is unclear, despite being an important phenomenon maintaining immune homeostasis.
Theinmozhi Arulraj, Sebastian C. Binder, Michael Meyer-Hermann, Michael Meyer-Hermann   +3 more
doaj   +1 more source

Double-Hit Gene Expression Signature Defines a Distinct Subgroup of Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma.

Journal of Clinical Oncology, 2019
PURPOSE High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH) has a poor outcome after standard chemoimmunotherapy. We sought to understand the biologic underpinnings of HGBL-DH/TH with BCL2 rearrangements (HGBL-DH/TH- BCL2)
D. Ennishi, A. Jiang, M. Boyle, B. Collinge, B. Grande, S. Ben-Neriah, C. Rushton, Jeffrey M. Tang, N. Thomas, G. Slack, P. Farinha, K. Takata, T. Miyata‐Takata, J. Craig, A. Mottok, B. Meissner, Saeed Saberi, Ali Bashashati, D. Villa, K. Savage, L. Sehn, R. Kridel, A. Mungall, M. Marra, Sohrab P. Shah, C. Steidl, J. Connors, R. Gascoyne, Ryan D. Morin, D. Scott   +29 more
semanticscholar   +1 more source

Novel specialized cell state and spatial compartments within the germinal center

Nature Immunology, 2020
Within germinal centers (GCs), complex and highly orchestrated molecular programs must balance proliferation, somatic hypermutation and selection to both provide effective humoral immunity and to protect against genomic instability and neoplastic ...
Domenick E. Kennedy, Michael K. Okoreeh, M. Maienschein-Cline, Junting Ai, M. Veselits, Kaitlin C. McLean, Yogesh Dhungana, Hong Wang, Junmin Peng, H. Chi, M. Mandal, M. Clark   +11 more
semanticscholar   +1 more source

Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses

Journal of Experimental Medicine, 2018
T follicular helper (Tfh) cells are required to develop germinal center (GC) responses and drive immunoglobulin class switch, affinity maturation, and long-term B cell memory.
N. Pardi, Michael J. Hogan, Martin S Naradikian, Kaela Parkhouse, D. Cain, Letitia Jones, M. A. Moody, H. Verkerke, A. Myles, Elinor Willis, C. Labranche, D. Montefiori, Jenna L. Lobby, K. Saunders, H. Liao, Bette T. Korber, Laura L. Sutherland, R. Scearce, P. Hraber, I. Tombácz, Hiromi Muramatsu, Houping Ni, D. A. Balikov, Charles Li, B. Mui, Ying K. Tam, F. Krammer, K. Karikó, P. Polacino, L. Eisenlohr, T. D. Madden, M. Hope, M. Lewis, Kelly K. Lee, Shiu-Lok Hu, S. Hensley, M. Cancro, B. Haynes, D. Weissman   +38 more
semanticscholar   +1 more source

AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells. [PDF]

PLoS ONE, 2012
Upon activation, B cells divide, form a germinal center, and express the activation induced deaminase (AID), an enzyme that triggers somatic hypermutation of the variable regions of immunoglobulin (Ig) loci. Recent evidence indicates that at least 25% of
Hillary Selle Gramlich, Tara Reisbig, David G Schatz   +2 more
doaj   +1 more source

Immune metabolism regulation of the germinal center response

Experimental and Molecular Medicine, 2020
The humoral immune response requires germinal centers to produce high-affinity antigen-specific antibodies that counter pathogens. Numerous studies have provided a better understanding of how metabolic pathways regulate the development, activation and ...
Seung-Chul Choi, L. Morel
semanticscholar   +1 more source

BAFFR controls early memory B cell responses but is dispensable for germinal center function

Journal of Experimental Medicine, 2020
Early, germinal center–independent, memory B cell responses are exquisitely sensitive to upregulation and downregulation of cell-intrinsic BAFFR signaling.
A. Lau, Vivian M. Turner, Katherine Bourne, Jana R. Hermes, T. Chan, R. Brink   +5 more
semanticscholar   +1 more source