Results 81 to 90 of about 181,469 (346)

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

open access: yesFEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke   +2 more
wiley   +1 more source

Association of Cystic Medial Necrosis of the Aorta and Undiagnosed Thyroiditis [Scripta Medica] [PDF]

open access: yes, 1977
We have recently seen two patients with cystic medial necrosis of the aorta. The first patient died of a dissecting aneurysm of the thoracic aorta. At autopsy, classical Hashimoto’s thyroiditis was discovered.
Hain, John R., Wise, William S.
core   +1 more source

Atypical chemokine receptor 4 shapes activated B cell fate [PDF]

open access: yes, 2018
Activated B cells can initially differentiate into three functionally distinct fates-early plasmablasts (PBs), germinal center (GC) B cells, or early memory B cells-by mechanisms that remain poorly understood.
Alsharifi, Mohammed   +20 more
core   +2 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

A mathematical model for the germinal center morphology and affinity maturation [PDF]

open access: yesarXiv, 2002
During germinal center reactions the appearance of two specific zones is observed: the dark and the light zone. Up to now, the origin and function of these zones are poorly understood. In the framework of a stochastic and discrete model several possible pathways of zone development during germinal center reactions are investigated.
arxiv  

Non-Hausdorff germinal groupoids for actions of countable groups [PDF]

open access: yesarXiv, 2023
We study conditions under which the germinal groupoid associated to a minimal equicontinuous action of a countable group on a Cantor set has non-Hausdorff topology. We develop a new criterion, which serves as an obstruction for the \'etale topology on the groupoid to be non-Hausdorff.
arxiv  

A Probabilistic Model of the Germinal Center Reaction [PDF]

open access: yesFrontiers in Immunology, 2019
Frontiers in Immunology ...
Marcel Jan Thomas   +4 more
openaire   +6 more sources

Evolutionary interplay between viruses and R‐loops

open access: yesFEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi   +4 more
wiley   +1 more source

CRISPR-Mediated Slamf1Δ/Δ Slamf5Δ/Δ Slamf6Δ/Δ Triple Gene Disruption Reveals NKT Cell Defects but Not T Follicular Helper Cell Defects.

open access: yesPLoS ONE, 2016
SAP (SH2D1A) is required intrinsically in CD4 T cells to generate germinal center responses and long-term humoral immunity. SAP binds to SLAM family receptors, including SLAM, CD84, and Ly108 to enhance cytokine secretion and sustained T cell:B cell ...
Joyce K Hu   +3 more
doaj   +1 more source

Loss of HLA-DR expression and immunoblastic morphology predict adverse outcome in diffuse large B-cell lymphoma – analyses of cases from two prospective randomized clinical trials

open access: yesHaematologica, 2009
Background Research on prognostically relevant immunohistochemical markers in diffuse large B-cell lymphomas has mostly been performed on retrospectively collected clinical data.
Heinz-Wolfram Bernd   +19 more
doaj   +1 more source

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