Results 81 to 90 of about 3,641,641 (357)

Linking signaling and selection in the germinal center

Immunological Reviews, 2019
Germinal centers (GC) are sites of rapid B‐cell proliferation in response to certain types of immunization. They arise in about 1 week and can persist for several months. In GCs, B cells differentiate in a unique way and begin to undergo somatic mutation
M. Shlomchik, W. Luo, Florian J. Weisel
semanticscholar   +1 more source

A Probabilistic Model of the Germinal Center Reaction [PDF]

Frontiers in Immunology, 2019
Frontiers in Immunology ...
Marcel Jan Thomas, Marcel Jan Thomas, Ulf Klein, John Lygeros, María Rodríguez Martínez   +4 more
openaire   +6 more sources

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

CRISPR-Mediated Slamf1Δ/Δ Slamf5Δ/Δ Slamf6Δ/Δ Triple Gene Disruption Reveals NKT Cell Defects but Not T Follicular Helper Cell Defects.

PLoS ONE, 2016
SAP (SH2D1A) is required intrinsically in CD4 T cells to generate germinal center responses and long-term humoral immunity. SAP binds to SLAM family receptors, including SLAM, CD84, and Ly108 to enhance cytokine secretion and sustained T cell:B cell ...
Joyce K Hu, Jordan C Crampton, Michela Locci, Shane Crotty   +3 more
doaj   +1 more source

N‐methyl‐D‐aspartate receptor antibody production from germinal center reactions: Therapeutic implications

Annals of Neurology, 2018
N‐methyl‐D‐aspartate receptor (NMDAR) antibody encephalitis is mediated by immunoglobulin G (IgG) autoantibodies directed against the NR1 subunit of the NMDAR.
M. Makuch, Robert Wilson, Adam Al‐Diwani, J. Varley, Anne-Kathrin Kienzler, Jennifer Taylor, A. Berretta, Darren Fowler, B. Lennox, M. Leite, P. Waters, S. Irani   +11 more
semanticscholar   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Generation of antigen-specific memory CD4 T cells by heterologous immunization enhances the magnitude of the germinal center response upon influenza infection.

PLoS Pathogens
Current influenza vaccine strategies have yet to overcome significant obstacles, including rapid antigenic drift of seasonal influenza viruses, in generating efficacious long-term humoral immunity.
Linda M Sircy, Andrew G Ramstead, Lisa C Gibbs, Hemant Joshi, Andrew Baessler, Ignacio Mena, Adolfo García-Sastre, Lyska L Emerson, Keke C Fairfax, Matthew A Williams, J Scott Hale   +10 more
doaj   +1 more source

Loss of HLA-DR expression and immunoblastic morphology predict adverse outcome in diffuse large B-cell lymphoma – analyses of cases from two prospective randomized clinical trials

Haematologica, 2009
Background Research on prognostically relevant immunohistochemical markers in diffuse large B-cell lymphomas has mostly been performed on retrospectively collected clinical data.
Heinz-Wolfram Bernd, Marita Ziepert, Christoph Thorns, Wolfram Klapper, Hans-Heinrich Wacker, Michael Hummel, Harald Stein, Martin-Leo Hansmann, German Ott, Andreas Rosenwald, Hans-Konrad Müller-Hermelink, Thomas F. E. Barth, Peter Möller, Sergio B. Cogliatti, Michael Pfreundschuh, Norbert Schmitz, Lorenz Trümper, Silvia Höller, Markus Löffler, Alfred C. Feller   +19 more
doaj   +1 more source

PPARγ negatively regulates T cell activation to prevent follicular helper T cells and germinal center formation. [PDF]

PLoS ONE, 2014
Peroxisome proliferator-activated receptor gamma (PPARγ) is a transcription factor that regulates lipid and glucose metabolism. Although studies of PPARγ ligands have demonstrated its regulatory functions in inflammation and adaptive immunity, its ...
Hong-Jai Park, Do-Hyun Kim, Jin-Young Choi, Won-Ju Kim, Ji Yun Kim, Alireza G Senejani, Soo Seok Hwang, Lark Kyun Kim, Zuzana Tobiasova, Gap Ryol Lee, Joseph Craft, Alfred L M Bothwell, Je-Min Choi   +12 more
doaj   +1 more source

SnapShot: The Germinal Center Reaction

Cell, 2014
To produce high-affinity antibodies, B cells must undergo iterative cycles of targeted mutagenesis and affinity-based selection. These cycles take place in a structure known as the germinal center, which forms in secondary lymphoid organs upon exposure to antigenic stimuli. Here, we summarize our current understanding of the germinal center reaction.
openaire   +2 more sources