Results 81 to 90 of about 194,651 (386)

Prediction of clinical progression in nervous system diseases: plasma glial fibrillary acidic protein (GFAP)

European Journal of Medical Research
Glial fibrillary acidic protein (GFAP), an intracellular type III intermediate filament protein, provides structural support and maintains the mechanical integrity of astrocytes.
Xiaoxiao Zheng, Jingyao Yang, Yiwei Hou, Xin Shi, Kangding Liu   +4 more
semanticscholar   +1 more source

Alexander-disease mutation ofGFAPcauses filament disorganization and decreased solubility of GFAP [PDF]

Journal of Cell Science, 2005
Alexander disease is a fatal neurological illness characterized by white-matter degeneration and the formation of astrocytic cytoplasmic inclusions called Rosenthal fibers, which contain the intermediate filament glial fibrillary acidic protein (GFAP), the small heat-shock proteins HSP27 and αB-crystallin, and ubiquitin. Many Alexander-disease patients
Victoria C, Hsiao, Rujin, Tian, Heather, Long, Ming, Der Perng, Michael, Brenner, Roy A, Quinlan, James E, Goldman   +6 more
openaire   +2 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation. [PDF]

, 2005
Maternal embryonic leucine zipper kinase (MELK) was previously identified in a screen for genes enriched in neural progenitors. Here, we demonstrate expression of MELK by progenitors in developing and adult brain and that MELK serves as a marker for self-
Bajpai, Ruchi, Dougherty, Joseph D, Freije, William A, Geschwind, Daniel H, Groszer, Matthias, Imura, Tetsuya, Kelly, Theresa K, Kim, Kevin J, Kornblum, Harley I, Liu, Xin, Nakano, Ichiro, Nelson, Stanley F, Ou, Jing, Paucar, Andres A, Sofroniew, Michael V, Terskikh, Alexey V, Wu, Hong, Zewail, Amani   +17 more
core   +2 more sources

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

Activation of Egr-1 expression in astrocytes by HIV-1 Tat: new insights into astrocyte-mediated Tat neurotoxicity [PDF]

, 2011
Human immunodeficiency virus type 1 (HIV-1) Tat plays an important role in HIV-associated neuropathogenesis; the underlying mechanisms are still evolving. We have recently shown that HIV-1 Tat induces expression of glial fibrillary acidic protein (GFAP),
Fan, Yan, Green, Linden A., He, Johnny J., oh Kim, Byung, Zou, Wei   +4 more
core   +1 more source

Fibrinogen Changes Before and After Intravenous Thrombolysis as Predictors of Cerebral Injury and Clinical Outcomes in Acute Ischemic Stroke: A Multicenter Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma fibrinogen is essential in thrombosis and fibrinolysis, yet its dynamic changes pre‐ and post‐intravenous thrombolysis (IVT) for predicting brain injury severity and prognosis in acute ischemic stroke (AIS) patients remain unclear.
Wenhai Zhai, Yang Qu, Reziya Abuduxukuer, Kejia Zhang, Peng Zhang, Xin Tang, Huaimei Zhang, Lijuan Wang, Lichong Yang, Shuangxu Tan, Zhimei Yuan, Ce Han, Lili He, Yuping Zheng, Fenglan Zhao, Lijie Guo, Ligang Jiang, Jinfeng Li, Yongfei Jiang, Xuexia Zou, Dan Xu, Han Xu, Xiaojia Wang, Yingbin Qi, Xuefeng Hu, Yu Zhang, Zhen‐Ni Guo, Hang Jin, on behalf of the Biomarkers of Brain Injury Investigator Study Group   +28 more
wiley   +1 more source

Changes in the density of astrocytes in the brain of rats caused by a single prolonged stress [PDF]

Medicinski Podmladak
Introduction: Post-traumatic stress disorder (PTSD) is a chronic syndrome caused by a traumatic stressful event. Numerous patients do not respond to conventional therapy, which shows that the pathogenetic mechanisms of PTSD are insufficiently known.
Ivaz Sava, Stojković Tihomir, Petronijević Nataša   +2 more
doaj   +1 more source

Regional astrocyte IFN signaling restricts pathogenesis during neurotropic viral infection [PDF]

, 2017
Type I IFNs promote cellular responses to viruses, and IFN receptor (IFNAR) signaling regulates the responses of endothelial cells of the blood-brain barrier (BBB) during neurotropic viral infection.
Ali, An, Archambault, Brian P. Daniels, Brien, Cramer, Daniels, Douglas M. Durrant, Furr, Furr, Getts, Harsha Jujjavarapu, Hart, Helen M. Lazear, James P. White, Jessica L. Williams, Michael Gale, Michael S. Diamond, Morga, Pfefferkorn, Richard R. Green, Robyn S. Klein, Rothhammer, Wang   +23 more
core   +3 more sources

Association between plasma GFAP concentrations and MRI abnormalities in patients with CT-negative traumatic brain injury in the TRACK-TBI cohort: a prospective multicentre study.

Lancet Neurology, 2019
BACKGROUND After traumatic brain injury (TBI), plasma concentration of glial fibrillary acidic protein (GFAP) correlates with intracranial injury visible on CT scan. Some patients with suspected TBI with normal CT findings show pathology on MRI.
J. Yue, E. Yuh, F. Korley, E. Winkler, Xiaoying Sun, Ross C. Puffer, Hansen Deng, W. Choy, Ankush Chandra, Sabrina R. Taylor, Adam R Ferguson, J. Huie, Miri Rabinowitz, A. Puccio, P. Mukherjee, M. Vassar, Kevin K. W. Wang, R. Diaz-Arrastia, D. Okonkwo, Sonia Jain, G. Manley, O. Adeoye, N. Badjatia, Kim Boase, Yelena G. Bodien, M. R. Bullock, R. Chesnut, J. Corrigan, K. Crawford, S. Dikmen, A. Duhaime, R. Ellenbogen, V. Feeser, B. Foreman, Raquel C Gardner, É. Gaudette, J. Giacino, D. Goldman, Luis Gonzalez, S. Gopinath, R. Gullapalli, J. Hemphill, G. Hotz, J. Kramer, Natalie P. Kreitzer, H. Levin, C. Lindsell, J. Machamer, C. Madden, Alastair J. Martin, T. McAllister, M. McCrea, R. Merchant, L. Nelson, Florence Noel, E. Palacios, D. Perl, C. Robertson, J. Rosand, A. Sander, G. Satris, David M Schnyer, S. Seabury, M. Sherer, Murray B. Stein, N. Temkin, A. Toga, A. Valadka, P. Vespa, R. Zafonte   +69 more
semanticscholar   +1 more source