GHR gene transcript heterogeneity may explain phenotypic variability in GHR pseudoexon (6Ψ) patients [PDF]
Endocrine Connections, 2020 Objectives: The homozygous GH receptor (GHR) pseudoexon (6Ψ) mutation leads to growth hormone insensitivity (GHI) with clinical and biochemical heterogeneity.
Sumana Chatterjee +8 more
doaj +4 more sources
METTL3-dependent m6A modification of GHR mRNA regulates mitochondrial function through mitochondrial biogenesis during myoblast differentiation [PDF]
Poultry ScienceN6-methyl-adenosine (m6A) methylation has recently been shown to play a critical role in muscle development. We recently revealed that local GHR knockdown impairs mitochondrial function by inhibiting mitochondrial biogenesis, thereby repressing myoblast ...
Changbin Zhao +6 more
doaj +2 more sources
Gestation Regulates Growth Hormone and Its Receptor Expression in Sheep Immune Organs [PDF]
BiologyThere are multiple adaptations in maternal physiology, hormones, and immunology during pregnancy. Growth hormone (GH) is not only produced by the pituitary but also secreted by extra-pituitary tissues.
Zhouyuan Li +5 more
doaj +2 more sources
Nonlinear association between gamma-glutamyl transferase to high-density lipoprotein cholesterol ratio and risk of progression from normoglycemia to prediabetes: a 5-year cohort study [PDF]
Frontiers in EndocrinologyObjectiveCurrent research on the association between the Gamma-glutamyl transferase to high-density lipoprotein ratio (GHR) and the risk of prediabetes (pre-DM) remains scarce.
Chuang Gao +5 more
doaj +2 more sources
Hypothalamic GHR—SIRT1 Axis in Fasting [PDF]
Cells, 2021 Many aspects of physiological functions are controlled by the hypothalamus, a brain region that connects the neuroendocrine system to whole-body metabolism. Growth hormone (GH) and the GH receptor (GHR) are expressed in hypothalamic regions known to participate in the regulation of feeding and whole-body energy homeostasis.
Juliana Bezerra Medeiros de Lima +5 more
openaire +3 more sources
Frontiers in Endocrinology, 2021 PurposeLaron syndrome (LS) is a severe growth disorder caused by GHR gene mutation or post-receptor pathways defect. The clinical features of these patients collected in our present study were summarized, GHR gene variants were investigated and further ...
Ran Li +10 more
doaj +1 more source
Expression of a hindlimb-determining factor Pitx1 in the forelimb of the lizard Pogona vitticeps during morphogenesis [PDF]
Open Biology, 2016 With over 9000 species, squamates, which include lizards and snakes, are the largest group of reptiles and second-largest order of vertebrates, spanning a vast array of appendicular skeletal morphology.
Jane Melville +5 more
doaj +1 more source
GHR/PRLR Heteromultimer Is Composed of GHR Homodimers and PRLR Homodimers [PDF]
Molecular Endocrinology, 2016 GH receptor (GHR) and prolactin (PRL) receptor (PRLR) are homologous transmembrane cytokine receptors. Each prehomodimerizes and ligand binding activates Janus Kinase 2 (JAK2)-signal transducer and activator of transcription (STAT) signaling pathways by inducing conformational changes within receptor homodimers.
Ying, Liu +8 more
openaire +2 more sources
Disulfide Linkage of Growth Hormone (GH) Receptors (GHR) Reflects GH-induced GHR Dimerization [PDF]
Journal of Biological Chemistry, 1999 The growth hormone (GH) receptor (GHR) binds GH in its extracellular domain and transduces activating signals via its cytoplasmic domain. Both GH-induced GHR dimerization and JAK2 tyrosine kinase activation are critical in initiation of GH signaling. We previously described a rapid GH-induced disulfide linkage of GHRs in human IM-9 cells. In this study,
Yue Zhang +3 more
openaire +2 more sources
ARCGHR Neurons Regulate Muscle Glucose Uptake
Cells, 2021 The growth hormone receptor (GHR) is expressed in brain regions that are known to participate in the regulation of energy homeostasis and glucose metabolism.
Juliana Bezerra Medeiros de Lima +10 more
doaj +1 more source