Results 31 to 40 of about 17,618 (160)

Ghrelin reverses ductular reaction and hepatic fibrosis in a rodent model of cholestasis

Scientific Reports, 2020
The orexigenic peptide ghrelin (Ghr) stimulates hunger signals in the hypothalamus via growth hormone secretagogue receptor (GHS-R1a). Gastric Ghr is synthetized as a preprohormone which is proteolytically cleaved, and acylated by a membrane-bound acyl ...
Anca D. Petrescu, Stephanie Grant, Elaina Williams, Gabriel Frampton, Evan H. Reinhart, Amy Nguyen, Suyeon An, Matthew McMillin, Sharon DeMorrow   +8 more
doaj   +1 more source

A Conformationally Sensitive GHR [Growth Hormone (GH) Receptor] Antibody: Impact on GH Signaling and GHR Proteolysis [PDF]

Molecular Endocrinology, 2004
The GH receptor (GHR) mediates metabolic and somatogenic actions of GH. Its extracellular domain (ECD; residues 1-246) has two subdomains, each with seven beta strands organized into two antiparallel beta sheets, connected by a short hinge region. Most of the ECD residues involved in GH binding reside in subdomain 1, whereas subdomain 2 harbors a ...
Jiang, J., Wang, X. D., He, K., Li, X., Chen, C. M., Sayeski, P. P., Waters, M. J., Frank, S. J.   +7 more
openaire   +3 more sources

Centrosomal JAK2 Tyrosine Kinase Regulates Primary Cilia Length, Cell Proliferation, and Cilia Orientation During Cell Migration. [PDF]

FASEB J
Growth hormone (GH) activates GHR at the primary cilium and stimulates centrosomal JAK2. JAK2 centrosomal localization requires both its SH2 domain and kinase activity. Cells expressing JAK2 variants deficient in centrosomal targeting show impaired control of cilia length, reduced proliferation, and cell migration compared with parental and JAK2 WT ...
Karki G, Boone L, Klaiber T, Lambert T, Kimball B, Burkhart B, Youssef M, Diakonova M.   +7 more
europepmc   +2 more sources

Autocrine/paracrine actions of growth hormone in human melanoma cell lines

Biochemistry and Biophysics Reports, 2020
Melanoma is the most aggressive skin cancer. Its aggressiveness is most commonly attributed to ERK pathway mutations leading to constitutive signaling.
Ashiya Buckels, Yue Zhang, Jing Jiang, Mohammad Athar, Farrukh Afaq, Lalita Shevde-Samant, Stuart J. Frank   +6 more
doaj   +1 more source

SINE Insertion in the Intron of Pig GHR May Decrease Its Expression by Acting as a Repressor

Animals, 2021
The genetic diversity of the GH/IGF axis genes and their association with the variation of gene expression and phenotypic traits, principally represented by SNPs, have been extensively reported.
Cai Chen, Yao Zheng, Mengli Wang, Eduard Murani, Enrico D’Alessandro, Ali Shoaib Moawad, Xiaoyan Wang, Klaus Wimmers, Chengyi Song   +8 more
doaj   +1 more source

Shifting in the shadows: Morphofunctional variations of Miconia sellowiana Naudin (Melastomataceae) associated with cave environments. [PDF]

Plant Biol (Stuttg)
Cave environments filter plant traits, selecting thinner, smaller leaves with reduced photosynthetic and vascular structures. Abstract Caves present unique ecological conditions that influence the distribution and adaptation of species, yet studies on cave‐associated vegetation remain limited.
Rosa GH, Cardoso RC, Ferreira RL, Souza-Silva M.   +3 more
europepmc   +2 more sources

Tissue-Specific GHR Knockout Mice: An Updated Review [PDF]

Frontiers in Endocrinology, 2020
Growth hormone (GH) signaling plays a key role in mediating growth, development, metabolism, and lifespan regulation. However, the mechanisms of longevity regulation at the cellular and molecular level are still not well-understood. An important area in the field of GH research is in the development of advanced transgenic systems for conditional ...
Akash Nagarajan, Hemant Srivastava, Joseph Jablonsky, Liou Y. Sun   +3 more
openaire   +3 more sources

Interaction of growth hormone receptor/binding protein gene disruption and caloric restriction for insulin sensitivity and attenuated aging [v1; ref status: indexed, http://f1000r.es/4fk]

F1000Research, 2014
The correlation of physiological sensitivity to insulin (vis-à-vis glycemic regulation) and longevity is extensively established, creating a justifiable gerontological interest on whether insulin sensitivity is causative, or even predictive, of some or ...
Oge Arum, Jamal Saleh, Ravneet Boparai, Jeremy Turner, John Kopchick, Romesh Khardori, Andrzej Bartke   +6 more
doaj   +1 more source

Growth Hormone Receptor Regulation in Cancer and Chronic Diseases

Frontiers in Endocrinology, 2020
The GHR signaling pathway plays important roles in growth, metabolism, cell cycle control, immunity, homeostatic processes, and chemoresistance via both the JAK/STAT and the SRC pathways. Dysregulation of GHR signaling is associated with various diseases
Ger J. Strous, Ger J. Strous, Ana Da Silva Almeida, Joyce Putters, Julia Schantl, Magdalena Sedek, Johan A. Slotman, Tobias Nespital, Gerco C. Hassink, Jan A. Mol   +9 more
doaj   +1 more source

Identification of growth hormone receptor (GHR) tyrosine residues required for GHR phosphorylation and JAK2 and STAT5 activation [PDF]

Molecular Endocrinology, 1996
To determine whether GH receptor (GHR) cytoplasmic tyrosine residue(s) and tyrosine phosphorylation are required for signal transduction, we have substituted the eight porcine (p) GHR cytoplasmic tyrosines with phenylalanine individually or in a stepwise manner from the C terminus.
X, Wang, C J, Darus, B C, Xu, J J, Kopchick   +3 more
openaire   +3 more sources