Results 51 to 60 of about 22,382 (200)

Tyrosine kinases compete for growth hormone receptor binding and regulate receptor mobility and degradation

Cell Reports, 2023
Summary: Growth hormone (GH) acts via JAK2 and LYN to regulate growth, metabolism, and neural function. However, the relationship between these tyrosine kinases remains enigmatic.
Yash Chhabra, Pernille Seiffert, Rachel S. Gormal, Manon Vullings, Christine Mei Mei Lee, Tristan P. Wallis, Farhad Dehkhoda, Sowmya Indrakumar, Nina L. Jacobsen, Kresten Lindorff-Larsen, Nela Durisic, Michael J. Waters, Frédéric A. Meunier, Birthe B. Kragelund, Andrew J. Brooks   +14 more
doaj   +1 more source

Changing climates and environments within the complex Middle to Late Pleistocene fill of an overdeepened valley at Niederweningen, Switzerland

Boreas, EarlyView.
Glacially overdeepened valleys in the northern Alpine Foreland preserve Middle to Late Pleistocene sedimentary sequences that may serve as valuable archives for reconstructing past environmental changes in response to shifts in climate. This study presents a multidisciplinary analysis of two sediment cores from the overdeepened Wehntal Valley at ...
Johannes M. Miocic, Nigel Thew, Ruth Drescher‐Schneider, Hans Rudolf Graf, Marlu Kühn, Frank Preusser, Werner H. Schoch, Lucia Wick, Heinz Furrer   +8 more
wiley   +1 more source

Consensus on energy‐based devices for keloids and hypertrophic scars: A Latin American Delphi study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Latin American Delphi consensus supports a sequential, multimodal approach to keloids and hypertrophic scars: vascular devices for early/inflammatory lesions; intralesional triamcinolone + 5‐fluorouracil and other injectable drugs for active scars; fractional lasers for texture; and pigment‐targeting therapies for dyschromia, prioritizing safety in ...
Gisele Viana de Oliveira, Patricia Apt Druck, Alvaro Andres Luque Acevedo, Doris Hexsel, Gabriel Teixeira Gontijo, Gabriel Huerta Rivera, Luis Leobardo Velázquez‐Arenas, Flávia Alvim Sant Anna Addor, Fátima Agüero Zaputovich, Hector Leal‐Silva, Sebastian Leal‐Delgado, Carlos Echevarría Escribens, Kleber Danilo Ollague Murillo, Susana Misticone, Leandra D'orsi Metsavaht, Johnny de la Riva, Daniel Ricardo Galimberti, Silvia Karina Kaminsky Jedwab, Hector Ricardo Galván Garcia, Marcia Ramos‐e‐Silva, Mariana Rocha Andrade, Eugenio Reis‐Filho, Marcio Roberto Silva, George Kroumpouzos, Daniela Guzmán‐Sánchez   +24 more
wiley   +1 more source

Expression of corticoid‐regulatory genes in the gills of Atlantic salmon (Salmo salar) parr and smolt and during salinity acclimation

Journal of Fish Biology, EarlyView.
Abstract In teleost fishes, cortisol is the major corticoid and has both glucocorticoid and mineralocorticoid actions. However, how fish tissues discriminate between these distinct corticosteroid actions is unclear. In mammals, the major factors responsible for intracellular corticosteroid regulation are glucocorticoid receptors (grs) and the ...
Makoto Kusakabe, Takashi Yada, Graham Young, Amy M. Regish, Stephen D. McCormick   +4 more
wiley   +1 more source

Preparation of a Growth Hormone Receptor/Prolactin Receptor Bispecific Antibody Antagonist Which Exhibited Anti-Cancer Activity

Frontiers in Pharmacology, 2020
Prolactin receptor (PRLR) and growth hormone receptor (GHR) are closely related to the occurrence and development of breast cancer, and breast cancer cell endogenously express GHR, PRLR and GHR-PRLR heterodimer.
Xin Chen, Di Wu, Yan Zheng, Xingxing Liu, Jianmeng Wang   +4 more
doaj   +1 more source

Method of meal delivery influences estimates of postprandial metabolism and alkaline tide in a benthic fish

Journal of Fish Biology, EarlyView.
Abstract Intragastric gavage is widely used in studies of digestive physiology to deliver standardised meals, yet it remains unclear whether it elicits postprandial metabolic and acid–base responses comparable to voluntary feeding. Here, we tested whether the method of meal delivery affects the magnitude and timing of the postprandial rise in metabolic
Junlin Chen, Barrett W. Wolfe, Harriet R. Goodrich   +2 more
wiley   +1 more source

Cumulative effects of lifelong systemic excess growth hormone on postcranial skeletal morphology in adult mice

Journal of Anatomy, EarlyView.
Our μCT‐based pilot study reveals size and shape disparity in the adult postcranial skeleton of growth‐hormone model (bGH) mice relative to wild‐type mice. bGH mice have larger and more sexually dimorphic bones, with a systemic radiodensity increase in bony sesamoids and associated, but typically uncalcified, soft tissues.
Joseph R. Groenke, Huanhuan Liu, Grace Lach, Abhishek Wajpe, Darlene Berryman, John J. Kopchick, Shouan Zhu, Patrick M. O'Connor   +7 more
wiley   +1 more source

Correlation between gallstones and fasting blood glucose to serum high-density lipoprotein cholesterol ratio among American adults

Frontiers in Medicine
BackgroundResearch indicates that the ratio of fasting blood glucose (FBG) to serum high-density lipoprotein cholesterol (HDL-C) (GHR) can accurately predict many diseases.
Bo Wu, Huachao Zheng, Caixiang Zhuang, Jiesheng Mao, Luo Yuncheng, Lidong Huang, Min Li, Zhao Feiyang, Sisi Lin, Pengwei Wang, Yiren Hu   +10 more
doaj   +1 more source

Leibniz on Compossibility: Towards a Neo‐Logical Interpretation

Theoria, EarlyView.
ABSTRACT Leibniz's concept of compossibility explains why not all possible substances are actualised, thereby resisting Spinoza's necessitarianism. Yet, the precise basis of incompossibility remains unresolved. The influential ‘logical’ interpretation—exemplified by the Hintikka–D'Agostino thesis—locates incompossibility in contradictions among ...
Jun Young Kim
wiley   +1 more source

MiR-139 suppresses β-casein synthesis and proliferation in bovine mammary epithelial cells by targeting the GHR and IGF1R signaling pathways

BMC Veterinary Research, 2017
Background MicroRNAs have important roles in many biological processes. However, the role of miR-139 in healthy mammary gland remains unclear. The objective of this study was to investigate the effects of miR-139 on lactation in dairy cows. Results Here,
Yingjun Cui, Xia Sun, Lianfeng Jin, Guangpu Yu, Qingzhang Li, Xuejun Gao, Jinxia Ao, Chunmei Wang   +7 more
doaj   +1 more source