Results 111 to 120 of about 93,938 (325)
Frontiers in Endocrinology, 2015 Ghrelin is a 28 amino-acid hormonal peptide that is intimately related to the regulation of food intake and body weight. Once secreted, ghrelin binds to the growth hormone secretagogue receptor-1a (GHSR-1a), the only known receptor for ghrelin and is ...
Martin K Wellman +7 more
doaj +1 more source
Small intestinal development in suckling rats after enteral obestatin administration [PDF]
, 2018 This study investigated the effect of enteral administration of obestatin on the development of small intestine, as well as oxidative stress markers and trancriptomic profile of gastrointestinal genes. Suckling rats were assigned to 3 groups treated with:
Grzesiak, Paulina +8 more
core +1 more source
Arrestin‐centred interactions at the membrane and their conformational determinants
British Journal of Pharmacology, EarlyView.Abstract More than 30 years after their discovery, arrestins are recognised multiprotein scaffolds that play essential roles in G protein‐coupled receptor (GPCR) regulation and signalling. Originally named for their capacity to hinder GPCR coupling to G proteins and facilitate receptor desensitisation, arrestins have emerged as key hubs for a myriad of
Owen Underwood +3 more
wiley +1 more source
Central ghrelin production does not substantially contribute to systemic ghrelin concentrations: a study in two subjects with active acromegaly [PDF]
, 2002 INTRODUCTION: In an animal model of acromegaly (PEPCK-hGH transgenic mice), low systemic levels of ghrelin have been observed compared with normal mice.
Broglio, F. (Fabio) +5 more
core +2 more sources
Clinical Obesity, Volume 15, Issue 2, April 2025.Summary Background Bariatric surgery is very effective in long‐term weight management. The present study was undertaken to investigate the short‐term effects of sleeve gastrectomy (SG) and of Roux‐en‐Y gastric bypass (RYGB) on (a) gastrointestinal (GI) motility, that is gastric emptying and oro‐cecal transit time and (b) secretion of regulatory gut ...
Jennifer A. Wilbrink +4 more
wiley +1 more source
Ghrelin and vascular protection [PDF]
Vascular Biology, 2019 Ghrelin is a small peptide with important roles in the regulation of appetite, gut motility, glucose homeostasis as well as cardiovascular protection. This review highlights the role that acyl ghrelin plays in maintaining normal endothelial function by maintaining the balance of vasodilator-vasoconstrictor factors, inhibiting inflammatory cytokine ...
Rajesh Katare +8 more
openaire +4 more sources
From Belly to Brain: Targeting the Ghrelin Receptor in Appetite and Food Intake Regulation
International Journal of Molecular Sciences, 2017 Ghrelin is the only known peripherally-derived orexigenic hormone, increasing appetite and subsequent food intake. The ghrelinergic system has therefore received considerable attention as a therapeutic target to reduce appetite in obesity as well as to ...
Ken Howick +3 more
semanticscholar +1 more source
Ghrelin Strongly Stimulates Growth Hormone Release in Humans [PDF]
, 2000 Kazuhiko Takaya +15 more
openalex +2 more sources
Mechanisms Underlying Weight Loss and Metabolic Improvements in Rodent Models of Bariatric Surgery [PDF]
, 2014 Obesity is a growing health risk with few successful treatment options and fewer still that target both obesity and obesity-associated comorbidities. Despite ongoing scientific efforts, the most effective treatment option to date was not developed from ...
Arble, Deanna M. +2 more
core +2 more sources
Clinical Obesity, Volume 15, Issue 2, April 2025.Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton +4 more
wiley +1 more source