Results 1 to 10 of about 8,260 (216)

Growth Hormone Secretagogue Receptor (GHSR) Is Elevated in Myocardial Tissues of DMD mdx:utrn^−/− Mice, and Correlates Strongly with Inflammatory Markers, and Negatively with Cardiac Function [PDF]

Cells
Dilated cardiomyopathy affects greater than 1 in 2500 patients worldwide, including those with the neuromuscular disorder Duchenne muscular dystrophy (DMD).
Maedeh Naghibosadat, Andrew McClennan, Margarita Egiian, Reema Flynn-Rizk, Tyler Lalonde, Carlie Charron, Anish Chhabra, Leonard G. Luyt, Savita Dhanvantari, Lisa M. Hoffman   +9 more
doaj   +4 more sources

Temporal control of eating and body weight by GHSR-expressing suprachiasmatic nucleus neurons [PDF]

Cell Reports
Summary: Food consumption impacts body weight differently depending on the time of day. Here, we investigated whether suprachiasmatic nucleus (SCN) neurons responsive to the hormone ghrelin temporally regulate eating and body weight in mice.
Omprakash Singh, Sepideh Sheybani-Deloui, Soumya Kulkarni, Moyu Lyu, Bingbing Li, Salil Varshney, Kripa Shankar, Deepali Gupta, Luis Leon Mercado, Avi W. Burstein, Corine P. Richard, Connor Lawrence, Sherri Osborne-Lawrence, Jeffrey M. Zigman   +13 more
doaj   +3 more sources

Contribution of growth hormone secretagogue receptor (GHSR) signaling in the ventral tegmental area (VTA) to the regulation of social motivation in male mice [PDF]

Translational Psychiatry, 2021
Most psychiatric disorders are characterized by deficits in the ability to interact socially with others. Ghrelin, a hormone normally associated with the regulation of glucose utilization and appetite, is also implicated in the modulation of motivated ...
Su-Bin Park, Samantha King, David MacDonald, Anne Wilson, Harry MacKay, Barbara Woodside, Alfonso Abizaid   +6 more
doaj   +2 more sources

Molecular cloning and expression characteristics of ghrl and ghsr genes in bighead carp (Hypophthalmichthys nobilis)

Aquaculture and Fisheries
Ghrelin (ghrl) and its receptor gene ghsr (growth hormone secretagogue receptor) regulate numerous physiological functions, including growth hormone secretion and food intake.
Pan Wang, Jianjun Fu, Mingkun Luo, Xiulan Shi, Wenbin Zhu, Lanmei Wang, Shichang Shu, Zaijie Dong   +7 more
doaj   +2 more sources

GHSR‐Foxo1 Signaling in Macrophages Promotes Liver Fibrosis via Inflammatory Response and Hepatic Stellate Cell Activation [PDF]

Advanced Science
Liver fibrosis is a severe liver disease directly linked to chronic inflammation, in which hepatic macrophages play a key role. Growth hormone secretagogue receptor (GHSR) is the receptor of nutrient‐sensing hormone ghrelin that has essential functions ...
Da Mi Kim, Quan Pan, Zeyu Liu, Weiqi Ai, Hye Won Han, Sakhila K. Banu, Robert Y.L. Tsai, Gus A. Wright, Shaodong Guo, Yuxiang Sun   +9 more
doaj   +2 more sources

Myeloid GHSR Deficiency Protects Against Thermogenic Impairment in Aging Through Immune Remodeling of Brown Adipose Tissue [PDF]

Cells
Thermoregulatory dysfunction is a major pathophysiological consequence of aging, affecting many elderly individuals. Growth hormone secretagogue receptor (GHSR) regulates energy homeostasis and immune function.
Hye Won Han, Da Mi Kim, Reza Baratiboldaji, Hongying Wang, Zeyu Liu, Zheng Shen, Deepak K. Jha, Tadesse Teferra, Endang M. Septiningsih, Bhimanagouda Patil, Yuxiang Sun   +10 more
doaj   +2 more sources

Screening of GHSR, GHRHR, GH1 genes in isolated growth hormone deficiency disease in Egyptian patients [PDF]

Egyptian Journal of Medical Human Genetics
Background Isolated growth hormone deficiency (IGHD) is a hereditary disorder that causes significant short stature. GHD has a reported incidence of 1/4000–1/10,000 births.
Tamer H. A. Ammar, Ghada M. M. Al-Ettribi, Maha M. A. Abo Hashish, Tarek M. Farid, Amany A. Abou-Elalla, Manal M. Thomas   +5 more
doaj   +2 more sources

Midbrain ghrelin receptor signalling regulates binge drinking in a sex specific manner [PDF]

Nature Communications
Risky drinking rates are rising, particularly in women, yet sex as a biological variable has only recently gained traction. The centrally projecting Edinger-Westphal (EWcp) nucleus has emerged as a key regulator of alcohol consumption. Here we found that
Amy J. Pearl, Xavier J. Maddern, Paulo Pinares-Garcia, Lauren T. Ursich, Roberta G. Anversa, Arnav Shesham, Robyn M. Brown, Felicia M. Reed, William J. Giardino, Andrew J. Lawrence, Leigh C. Walker   +10 more
doaj   +2 more sources

Exploring the Relationship Between Growth Hormone Secretagogue Receptor (GHSR) Gene and Body Proportions in Bangkok Chickens: Insights from DNA Sequencing and Hin6I Enzyme-Restricted PCR-RFLP Analysis

Jurnal Medik Veteriner
The purpose of this study was to determine the diversity of the growth hormone secretagogue receptor (GHSR) gene and also to analyze the association of the GHSR gene with the body proportions of Bangkok chickens.
Gayuh Syaikhullah, Rosa Tri Hertamawati, Muhammad Adhyatma   +2 more
doaj   +3 more sources

GHSR agonism increases blood glucose but delays food intake in GHSR hyperresponsive rats. [PDF]

J Neuroendocrinol
Zizzari P, Ramírez-Penas O, Pons V, Oujezdska M, Sammarcelli AL, Saint-Yves T, Chevallier-Chantepie I, Baussart L, Nhan V, Phalip A, Gales C, Cota D, Noble F, Pantel J.   +13 more
europepmc   +3 more sources