Results 1 to 10 of about 8,222 (228)

GHSR-Foxo1 Signaling in Macrophages Promotes Liver Fibrosis via Inflammatory Response and Hepatic Stellate Cell Activation. [PDF]

Adv Sci (Weinh)
Macrophage GHSR‐Foxo1 axis regulates CCl4‐induced liver fibrosis by promoting inflammation and TGF‐β1‐mediated HSC activation. GHSR activates PKA‐dependent phosphorylation of Foxo1 at serine 273, promoting macrophage pro‐inflammatory polarization to enhance the production of pro‐inflammatory cytokines that damage hepatocytes, thereby inducing liver ...
Kim DM, Pan Q, Liu Z, Ai W, Han HW, Banu SK, Tsai RYL, Wright GA, Guo S, Sun Y.   +9 more
europepmc   +3 more sources

Loss-of-Function GHSR Variants Are Associated With Short Stature and Low IGF-I. [PDF]

J Clin Endocrinol Metab
Abstract Context The growth hormone (GH) secretagogue receptor, encoded by GHSR, is expressed on somatotrophs of the pituitary gland. Stimulation with its ligand ghrelin, as well as its constitutive activity, enhances GH secretion. Studies in knockout mice suggest that heterozygous loss-of-function of
Punt LD, Kooijman S, Mutsters NJM, Yue K, van der Kaay DCM, van Tellingen V, Bakker-van Waarde WM, Boot AM, van den Akker ELT, van Boekholt AA, de Groote K, Kruijsen AR, van Nieuwaal-van Maren NHG, Woltering MC, Heijligers M, van der Heyden JC, Bannink EMN, Rinne T, Hannema SE, de Waal WJ, Delemarre LC, Rensen PCN, de Bruin C, van Duyvenvoorde HA, Visser JA, Delhanty PJD, Losekoot M, Wit JM, Joustra SD.   +28 more
europepmc   +8 more sources

An atomic look at the interface of GHSR and its partners. [PDF]

Comput Struct Biotechnol J
G protein-coupled receptors (GPCRs) regulate cellular activity by transducing external signals and selectively coupling them to intracellular partners. Ghrelin receptor (GHSR) has garnered significant interest over the past decade owing to its diverse functional roles.
Barreto CAV, Moreira IS.
europepmc   +4 more sources

Chronic ghrelin administration suppresses IKK/NF‐κB/BACE1 mediated Aβ production in primary neurons and improves cognitive function via upregulation of PP1 in STZ‐diabetic rats [PDF]

Alzheimers Dement
Abstract Background To investigate the molecular mechanism of the brain‐gut peptide Ghrelin in improving cognitive function and attenuating Aβ deposition in hippocampal neurons. Method A classical STZ‐induced diabetic rat model was established using 6‐8 weeks old, which were divided into normal control group, diabetes mellitus (DM) group, DM+Ghrelin ...
Ma l, Qu Q.
europepmc   +2 more sources

Food and the brain: Neural and endocrine control of feeding, metabolism, and reproduction. [PDF]

J Neuroendocrinol
Abstract Feeding and reproductive function are regulated by intricate systems that monitor food availability and energy stores, and on the basis of energy status, promote or put a brake on reproduction. This is particularly evident in the systems that regulate feeding and reproductive state in female mammals.
da Silva Mansano N, Lieu CV, Abizaid A.
europepmc   +2 more sources

Determination of Biotin Interference in Pediatric Obesity Related ELISA Research Kits Biotin Interference in Manual ELISA Kits. [PDF]

J Clin Lab Anal
In this study, we aimed for the first time to demonstrate biotin interference in ELISA research kits used in the analysis of pediatric obesity parameters other than routine testing. Our study revealed that biotin interaction may occur in manual ELISA kits and may cause erroneous test results.
Kürkçü Kahraman E, Donma O, Donma MM, Yılmaz A, Güzel S.   +4 more
europepmc   +2 more sources

Neuroendocrinology meets addiction: Emerging pharmacotherapies on the horizon. [PDF]

J Intern Med
Abstract Alcohol and other substance use disorders (ASUDs) are prevalent and major contributors to global morbidity and mortality. Their impact extends beyond the individual, imposing significant burdens on families, communities, healthcare systems, and society at large.
Loften A, Farokhnia M, Vendruscolo LF, Leggio L.   +3 more
europepmc   +2 more sources

Bladder Cancer detection by urinary methylation markers GHSR/MAL: a validation study. [PDF]

World J Urol
Abstract Purpose Although cystoscopy is a reliable tool for detecting bladder cancer, it poses a high burden on patients and entails high costs. This highlights the need for non-invasive and cost-effective alternatives. This study aimed to validate a previously developed urinary methylation marker panel containing GHSR ...
Beijert IJ, van den Burgt Y, Hentschel AE, Bosschieter J, Kauer PC, Lissenberg-Witte BI, van Moorselaar RJA, Nieuwenhuijzen JA, Steenbergen RDM.   +8 more
europepmc   +4 more sources

9293 Do Obesity-Associated MRAP2 Variants Modulate MC4R and GHSR Signaling? [PDF]

J Endocr Soc
Abstract Disclosure: A.V. Rodriguez Rondon: None. F. Volker: None. M.S. Welling: None. C. de Groot: None. M.M. van Haelst: None. E.L. van den Akker: None. E.F. van Rossum: None. P.J. Delhanty: None. J.A. Visser: None. Melanocortin 2 receptor accessory protein 2 (MRAP2) is a membrane-bound protein expressed on hypothalamic ...
Rondon, Alejandra Virginia Rodriguez, Volker, Femke, Welling, Mila Sofie, de Groot, Corjan, van Haelst, Mieke M, van den Akker, Erica L T, van Rossum, Elisabeth F C, Delhanty, Patric John, Visser, Jenny A   +8 more
europepmc   +2 more sources

Ghrelin-GHSR-LEAP2 system in the pathophysiology of type 2 diabetes. [PDF]

iScience
Pu Y, Yang J, Li W, Wen Y, Zheng C, Li Y, Wu L, Ming Y, Zhao C, Chen C.   +9 more
europepmc   +3 more sources