Results 11 to 20 of about 3,121 (172)
Metabolic insights from a GHSR-A203E mutant mouse model [PDF]
Molecular Metabolism, 2020 Objective: Binding of ghrelin to its receptor, growth hormone secretagogue receptor (GHSR), stimulates GH release, induces eating, and increases blood glucose. These processes may also be influenced by constitutive (ghrelin-independent) GHSR activity, as
Lola J. Torz +17 more
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Molecular Metabolism, 2021 Objective: The orexigenic hormone ghrelin exerts its physiological effects by binding to and activating the growth hormone secretagogue receptor (GHSR). The recent development of a Ghsr-IRES-Cre knock-in mouse line has enabled to genetically access GHSR ...
Fiona Peris-Sampedro +5 more
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GHSR deficiency exacerbates Parkinson's disease pathology by impairing autophagy
Redox BiologyIn Parkinson's disease (PD), exogenous ghrelin protects dopaminergic neurons through its receptor, growth hormone secretagogue receptor (GHSR). However, in contrast to the strikingly low levels of ghrelin, GHSR is highly expressed in the substantia nigra
Xue Xiao +9 more
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Science-Business eXchange, 2009 Swedish researchers have used compounds from Aeterna Zentaris and Ipsen Group to develop evidence that ghrelin inhibition could treat alcohol dependence, if the receptor can be targeted without adversely affecting appetite or body weight.
Michael J. Haas
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An atomic look at the interface of GHSR and its partners
Computational and Structural Biotechnology JournalG protein-coupled receptors (GPCRs) regulate cellular activity by transducing external signals and selectively coupling them to intracellular partners. Ghrelin receptor (GHSR) has garnered significant interest over the past decade owing to its diverse functional roles.
Carlos A.V. Barreto, Irina S. Moreira
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Ghrelin/GHSR Axis Induced M2 Macrophage and Alleviated Intestinal Barrier Dysfunction in a Sepsis Rat Model by Inactivating E2F1/NF-κB Signaling [PDF]
Canadian Journal of Gastroenterology and Hepatology, 2023 Sepsis is an inflammatory reaction disorder state that is induced by infection. The activation and regulation of the immune system play an essential role in the development of sepsis.
Lei Zhu +7 more
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Frontiers in Pharmacology, 2021 The growth hormone secretagogue receptor (GHSR) signals in response to ghrelin, but also acts via ligand-independent mechanisms that include either constitutive activation or interaction with other G protein-coupled receptors, such as the dopamine 2 ...
Emilio R. Mustafá +11 more
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Journal of Cachexia, Sarcopenia and Muscle, 2021 Background Ghrelin may ameliorate cancer cachexia (CC) by preventing anorexia, muscle, and fat loss. However, the mechanisms mediating these effects are not fully understood. This study characterizes the pathways involved in muscle mass and strength loss
Haiming Liu +12 more
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GHSR hypermethylation: a promising pan-cancer marker [PDF]
Cell Cycle, 2015 The advent of high-throughput technologies such as microarrays, global gene knockout, and next generation sequencing (NGS) has revolutionized the field of molecular oncology. Large-scale endeavors of the kind represented by the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA) are generating comprehensive portraits of ...
Jörg Hoheisel +2 more
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Translational Psychiatry, 2021 Most psychiatric disorders are characterized by deficits in the ability to interact socially with others. Ghrelin, a hormone normally associated with the regulation of glucose utilization and appetite, is also implicated in the modulation of motivated ...
Su-Bin Park +6 more
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