Results 11 to 20 of about 8,260 (216)

Metabolic insights from a GHSR-A203E mutant mouse model [PDF]

Molecular Metabolism, 2020
Objective: Binding of ghrelin to its receptor, growth hormone secretagogue receptor (GHSR), stimulates GH release, induces eating, and increases blood glucose. These processes may also be influenced by constitutive (ghrelin-independent) GHSR activity, as
Lola J. Torz, Sherri Osborne-Lawrence, Juan Rodriguez, Zhenyan He, María Paula Cornejo, Emilio Román Mustafá, Chunyu Jin, Natalia Petersen, Morten A. Hedegaard, Maja Nybo, Valentina Martínez Damonte, Nathan P. Metzger, Bharath K. Mani, Kevin W. Williams, Jesica Raingo, Mario Perello, Birgitte Holst, Jeffrey M. Zigman   +17 more
doaj   +5 more sources

Genetic deletion of the ghrelin receptor (GHSR) impairs growth and blunts endocrine response to fasting in Ghsr-IRES-Cre mice

Molecular Metabolism, 2021
Objective: The orexigenic hormone ghrelin exerts its physiological effects by binding to and activating the growth hormone secretagogue receptor (GHSR). The recent development of a Ghsr-IRES-Cre knock-in mouse line has enabled to genetically access GHSR ...
Fiona Peris-Sampedro, Iris Stoltenborg, Marie V. Le May, Jeffrey M. Zigman, Roger A.H. Adan, Suzanne L. Dickson   +5 more
doaj   +4 more sources

GHSR deficiency exacerbates Parkinson's disease pathology by impairing autophagy

Redox Biology
In Parkinson's disease (PD), exogenous ghrelin protects dopaminergic neurons through its receptor, growth hormone secretagogue receptor (GHSR). However, in contrast to the strikingly low levels of ghrelin, GHSR is highly expressed in the substantia nigra
Xue Xiao, Tingting Tang, Mingxia Bi, Jing Liu, Mengru Liu, Qian Jiao, Xi Chen, Chunling Yan, Xixun Du, Hong Jiang   +9 more
doaj   +3 more sources

Loss-of-Function GHSR Variants Are Associated With Short Stature and Low IGF-I. [PDF]

J Clin Endocrinol Metab
Abstract Context The growth hormone (GH) secretagogue receptor, encoded by GHSR, is expressed on somatotrophs of the pituitary gland. Stimulation with its ligand ghrelin, as well as its constitutive activity, enhances GH secretion. Studies in knockout mice suggest that heterozygous loss-of-function of
Punt LD, Kooijman S, Mutsters NJM, Yue K, van der Kaay DCM, van Tellingen V, Bakker-van Waarde WM, Boot AM, van den Akker ELT, van Boekholt AA, de Groote K, Kruijsen AR, van Nieuwaal-van Maren NHG, Woltering MC, Heijligers M, van der Heyden JC, Bannink EMN, Rinne T, Hannema SE, de Waal WJ, Delemarre LC, Rensen PCN, de Bruin C, van Duyvenvoorde HA, Visser JA, Delhanty PJD, Losekoot M, Wit JM, Joustra SD.   +28 more
europepmc   +9 more sources

Short stature due to GHSR deficiency [PDF]

, 2020
INSERM
openalex   +2 more sources

The Ghrelin Receptor (Ghsr) Gene Polymorphism in Indonesian Local Chicken and Crossbreed Is Associated With Carcass Traits [PDF]

, 2018
Ghrelin receptor (GHSR) gene is candidate gene for growth performance in chicken by modulating growth hormone release from the pituitary by binding to its ligand of ghrelin.
Isyana Khaerunnisa, Jakaria Jakaria, Irma Isnafia Arief, Cahyo Budiman, Cece Sumantri   +4 more
openalex   +5 more sources

GHSR gene knockout alleviates the liver pathological response in Echinococcus granulosus infection by reducing parasite survival [PDF]

Veterinary Research
Cystic echinococcosis (CE) is a parasitic disease caused by the larval stage of Echinococcus granulosus, and the immunosuppressive microenvironment exacerbates disease progression.
Jiang Zhu, Tanfang Zhou, Guangfeng Chen, Huijing Gao, Xia Chen, Ayinula Tuohetali, Ya Song, Dongming Pang, Kalibixiati Aimulajiang   +8 more
doaj   +2 more sources

Obesity-Induced PVAT Dysfunction and Atherosclerosis Development: The Role of GHSR-1a in Increased Macrophage Infiltration and Adipocytokine Secretion [PDF]

Journal of Cardiovascular Development and Disease
In obesity, recent research revealed that increased expression of the growth hormone secretagogue receptor (GHSR) in macrophages plays a pivotal role in the development of meta-inflammation, promoting macrophage infiltration and pro-inflammatory ...
Sorin Nicolae Peiu, Florin Zugun-Eloae, Bogdan Stoica, Ecaterina Anisie, Diana Gabriela Iosep, Mihai Danciu, Iustina Silivestru-Crețu, Fawzy Akad, Andrei Nicolae Avadanei, Laura Condur, Radu Florin Popa, Veronica Mocanu   +11 more
doaj   +2 more sources

Therapeutic potential of ghrelin/GOAT/GHSR system in gastrointestinal disorders [PDF]

Frontiers in Nutrition
Ghrelin, a peptide primarily secreted in the stomach, acts via the growth hormone secretagogue receptor (GHSR). It regulates several physiological processes, such as feeding behavior, energy homeostasis, glucose and lipid metabolism, cardiovascular function, bone formation, stress response, and learning.
Yunxiao Ma, Qihui Yan, Ping Wang, Weiying Guo, Lu Yu   +4 more
openalex   +4 more sources

Ghrelin Modulates Physiologic and Pathologic Retinal Angiogenesis through GHSR-1a [PDF]

Investigative Opthalmology & Visual Science, 2011
Vascular degeneration and the ensuing abnormal vascular proliferation are central to proliferative retinopathies. Given the metabolic discordance associated with these diseases, the authors explored the role of ghrelin and its growth hormone secretagogue receptor 1a (GHSR-1a) in proliferative retinopathy.In a rat model of oxygen-induced retinopathy ...
Karine Zaniolo, Przemysław Sapieha, Zhuo Shao, Andreas Stahl, Tang Zhu, Sophie Tremblay, Émilie Picard, Ankush Madaan, Martine Blais, Pierre Lachapelle, Joseph Mancini, Pierre Hardy, Lois E. H. Smith, Huy Ong, Sylvain Chemtob   +14 more
openalex   +6 more sources