Results 11 to 20 of about 8,222 (228)

Metabolic insights from a GHSR-A203E mutant mouse model [PDF]

Molecular Metabolism, 2020
Binding of ghrelin to its receptor, growth hormone secretagogue receptor (GHSR), stimulates GH release, induces eating, and increases blood glucose. These processes may also be influenced by constitutive (ghrelin-independent) GHSR activity, as suggested by findings in short people with naturally occurring GHSR-A204E mutations and reduced food intake ...
Lola J. Torz, Sherri Osborne-Lawrence, Juan Rodriguez, Zhenyan He, María Paula Cornejo, Emilio Román Mustafá, Chunyu Jin, Natalia Petersen, Morten A. Hedegaard, Maja Nybo, Valentina Martínez Damonte, Nathan P. Metzger, Bharath K. Mani, Kevin W. Williams, Jesica Raingo, Mario Perello, Birgitte Holst, Jeffrey M. Zigman   +17 more
openaire   +6 more sources

Growth Hormone Secretagogue Receptor (GHSR) Is Elevated in Myocardial Tissues of DMD <i>mdx:utrn</i>^-/- Mice, and Correlates Strongly with Inflammatory Markers, and Negatively with Cardiac Function. [PDF]

Cells
Dilated cardiomyopathy affects greater than 1 in 2500 patients worldwide, including those with the neuromuscular disorder Duchenne muscular dystrophy (DMD).
Naghibosadat M, McClennan A, Egiian M, Flynn-Rizk R, Lalonde T, Charron C, Chhabra A, Luyt LG, Dhanvantari S, Hoffman LM.   +9 more
europepmc   +5 more sources

Genetic deletion of the ghrelin receptor (GHSR) impairs growth and blunts endocrine response to fasting in Ghsr-IRES-Cre mice

Molecular Metabolism, 2021
The orexigenic hormone ghrelin exerts its physiological effects by binding to and activating the growth hormone secretagogue receptor (GHSR). The recent development of a Ghsr-IRES-Cre knock-in mouse line has enabled to genetically access GHSR-expressing neurons.
Peris-Sampedro F, Stoltenborg I, Le May MV, Zigman JM, Adan RAH, Dickson SL   +5 more
openaire   +5 more sources

Contribution of growth hormone secretagogue receptor (GHSR) signaling in the ventral tegmental area (VTA) to the regulation of social motivation in male mice [PDF]

Translational Psychiatry, 2021
Most psychiatric disorders are characterized by deficits in the ability to interact socially with others. Ghrelin, a hormone normally associated with the regulation of glucose utilization and appetite, is also implicated in the modulation of motivated ...
Su‐Bin Park, Samantha J. King, David MacDonald, Anne P. Wilson, Harry A. Mackay, Barbara Woodside, Alfonso Abizaid   +6 more
openalex   +2 more sources

The Ghrelin Receptor (Ghsr) Gene Polymorphism in Indonesian Local Chicken and Crossbreed is Associated with Carcass Traits [PDF]

, 2017
Ghrelin receptor (GHSR) gene is candidate gene for growth performance in chicken by modulating growth hormone release from the pituitary by binding to its ligand of ghrelin.
Arief, I. I. (Irma), Budiman, C. (Cahyo), Jakaria, J. (Jakaria), Khaerunnisa, I. (Isyana), Sumantri, C. (Cece)   +4 more
core   +4 more sources

Molecular cloning and expression characteristics of ghrl and ghsr genes in bighead carp (Hypophthalmichthys nobilis)

Aquaculture and Fisheries
Ghrelin (ghrl) and its receptor gene ghsr (growth hormone secretagogue receptor) regulate numerous physiological functions, including growth hormone secretion and food intake.
Pan Wang, Jianjun Fu, Mingkun Luo, Xiulan Shi, Wenbin Zhu, Lanmei Wang, Шичанг Шу, Zaijie Dong   +7 more
openalex   +3 more sources

GHSR deficiency exacerbates Parkinson's disease pathology by impairing autophagy

Redox Biology
In Parkinson's disease (PD), exogenous ghrelin protects dopaminergic neurons through its receptor, growth hormone secretagogue receptor (GHSR). However, in contrast to the strikingly low levels of ghrelin, GHSR is highly expressed in the substantia nigra (SN). What role does GHSR play in dopaminergic neurons is unknown.
Xue Xiao, Tingting Tang, Mingxia Bi, Jing Liu, Mengru Liu, Qian Jiao, Xi Chen, Chunling Yan, Xixun Du, Hong Jiang   +9 more
openaire   +4 more sources

Ghrelin Modulates Physiologic and Pathologic Retinal Angiogenesis through GHSR-1a [PDF]

Investigative Opthalmology & Visual Science, 2011
Vascular degeneration and the ensuing abnormal vascular proliferation are central to proliferative retinopathies. Given the metabolic discordance associated with these diseases, the authors explored the role of ghrelin and its growth hormone secretagogue receptor 1a (GHSR-1a) in proliferative retinopathy.In a rat model of oxygen-induced retinopathy ...
Zaniolo, Karine, Sapieha, Przemyslaw, Shao, Zhuo, Stahl, Andreas, Zhu, Tang, Tremblay, Sophie, Picard, Emilie, Madaan, Ankush, Blais, Martine, Lachapelle, Pierre, Mancini, Joseph, Hardy, Pierre, Smith, Lois E. H., Ong, Huy, Chemtob, Sylvain   +14 more
openaire   +6 more sources

Screening of GHSR, GHRHR, GH1 genes in isolated growth hormone deficiency disease in Egyptian patients [PDF]

Egyptian Journal of Medical Human Genetics
Background Isolated growth hormone deficiency (IGHD) is a hereditary disorder that causes significant short stature. GHD has a reported incidence of 1/4000–1/10,000 births.
Tamer H. A. Ammar, Ghada M. M. Al-Ettribi, Adel F. Hashish, Tarek M. Farid, Amany A. Abou-Elalla, Manal M. Thomas   +5 more
openalex   +2 more sources

Therapeutic potential of ghrelin/GOAT/GHSR system in gastrointestinal disorders [PDF]

Frontiers in Nutrition
Ghrelin, a peptide primarily secreted in the stomach, acts via the growth hormone secretagogue receptor (GHSR). It regulates several physiological processes, such as feeding behavior, energy homeostasis, glucose and lipid metabolism, cardiovascular function, bone formation, stress response, and learning.
Yunxiao Ma, Qihui Yan, Ping Wang, Weiying Guo, Lu Yu   +4 more
openaire   +4 more sources