Results 21 to 30 of about 3,121 (172)
Heritage Building Stones from Évora, Portugal [PDF]
, 2020 The city of Évora, a World Heritage Site recognized by UNESCO in 1986, also owes this recognition to the stones that built its monuments and preserve them until today. This work brings together the contributions that we have gathered over the past three
Lope, Luís
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Biomolecules, 2022 Ghrelin receptor, a growth hormone secretagogue receptor (GHS-R), is expressed in the pancreas. Emerging evidence indicates that GHS-R is involved in the regulation of glucose-stimulated insulin secretion (GSIS), but the mechanism by which GHS-R ...
Geetali Pradhan +11 more
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Biomolecules, 2022 The gut peptide, ghrelin, mediates energy homeostasis and reproduction by acting through its receptor, growth hormone secretagogue receptor (GHSR), expressed in hypothalamic neurons in the arcuate (ARC).
Kristie Conde +9 more
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Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet [PDF]
Communications BiologyThe stomach-derived hormone ghrelin regulates essential physiological functions. The ghrelin receptor (GHSR) has ligand-independent actions; therefore, GHSR gene deletion may be a reasonable approach to investigate the role of this system in feeding ...
András H. Lékó +22 more
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Involvement of the GHSR in the developmental programming and metabolic disturbances induced by maternal undernutrition [PDF]
The Journal of Nutritional Biochemistry, 2020 The mismatch between maternal undernutrition and adequate nutrition after birth increases the risk of developing metabolic diseases. We aimed to investigate whether the hyperghrelinemia during maternal undernourishment rewires the hypothalamic development of the offspring and contributes to the conversion to an obese phenotype when fed a high-fat diet (
Bart Van der Schueren +6 more
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CJC Open, 2021 Background: The hormone ghrelin and its receptor, the growth hormone secretagogue receptor (GHSR) are expressed in myocardium. GHSR binding activates signalling pathways coupled to cardiomyocyte survival and contractility.
Rebecca Sullivan, BSc +7 more
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Loss-of-function GHSR variants are associated with short stature and low IGF-I
The Journal of Clinical Endocrinology & MetabolismAbstract Context The growth hormone (GH) secretagogue receptor, encoded by GHSR, is expressed on somatotrophs of the pituitary gland. Stimulation with its ligand ghrelin, as well as its constitutive activity, enhances GH secretion. Studies in knockout mice suggest that heterozygous loss-of-function of
Lauren D Punt +28 more
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Neuronal GHS-R Differentially Modulates Feeding Patterns under Normal and Obesogenic Conditions
Biomolecules, 2022 The orexigenic hormone ghrelin increases food intake and promotes obesity through its receptor, growth hormone secretagogue receptor (GHS-R). We previously reported two neuron-specific GHS-R knockout mouse lines, namely pan-neuronal deletion by Syn1-cre ...
Jong Han Lee +3 more
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Aquaculture and FisheriesGhrelin (ghrl) and its receptor gene ghsr (growth hormone secretagogue receptor) regulate numerous physiological functions, including growth hormone secretion and food intake.
Pan Wang +7 more
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Molecular Metabolism, 2021 Objective: Acyl-ghrelin regulates eating, body weight, blood glucose, and GH secretion upon binding to its receptor GHSR (growth hormone secretagogue receptor; ghrelin receptor). GHSR is distributed in several brain regions and some peripheral cell-types
Deepali Gupta +11 more
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