Results 21 to 30 of about 8,260 (216)
Journal of Cachexia, Sarcopenia and Muscle, 2021 Background Ghrelin may ameliorate cancer cachexia (CC) by preventing anorexia, muscle, and fat loss. However, the mechanisms mediating these effects are not fully understood. This study characterizes the pathways involved in muscle mass and strength loss
Haiming Liu +12 more
doaj +1 more source
Frontiers in Pharmacology, 2021 The growth hormone secretagogue receptor (GHSR) signals in response to ghrelin, but also acts via ligand-independent mechanisms that include either constitutive activation or interaction with other G protein-coupled receptors, such as the dopamine 2 ...
Emilio R. Mustafá +11 more
doaj +1 more source
6789 Do Obesity-Associated MRAP2 Variants Modulate MC4R and GHSR Signaling?
Journal of the Endocrine SocietyAbstract Disclosure: A.V. Rodriguez Rondon: None. F. Volker: None. M.S. Welling: None. C. de Groot: None. M.M. van Haelst: None. E.L. van den Akker: None. E.F. van Rossum: None. P.J. Delhanty: None. J.A. Visser: None. Melanocortin 2 receptor accessory protein 2 (MRAP2) is a membrane-bound protein expressed on hypothalamic ...
Alejandra Virginia Rodriguez Rondon +8 more
openalex +2 more sources
Dopamine D2 receptor; ghrelin receptor (GHSR) [PDF]
Science-Business eXchange, 2012 openalex +2 more sources
GHSR hypermethylation: a promising pan-cancer marker [PDF]
Cell Cycle, 2015 The advent of high-throughput technologies such as microarrays, global gene knockout, and next generation sequencing (NGS) has revolutionized the field of molecular oncology. Large-scale endeavors of the kind represented by the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA) are generating comprehensive portraits of ...
Pouria, Jandaghi +2 more
openaire +2 more sources
Heritage Building Stones from Évora, Portugal [PDF]
, 2020 The city of Évora, a World Heritage Site recognized by UNESCO in 1986, also owes this recognition to the stones that built its monuments and preserve them until today. This work brings together the contributions that we have gathered over the past three
Lope, Luís
core +1 more source
Ghrelin/GHSR System in Depressive Disorder: Pathologic Roles and Therapeutic Implication
Current Issues in Molecular BiologyDepression is the most common chronic mental illness and is characterized by low mood, insomnia, and affective disorders. However, its pathologic mechanisms remain unclear. Numerous studies have suggested that the ghrelin/GHSR system may be involved in the pathophysiologic process of depression.
Xingli Pan +4 more
openalex +5 more sources
Biomolecules, 2022 The gut peptide, ghrelin, mediates energy homeostasis and reproduction by acting through its receptor, growth hormone secretagogue receptor (GHSR), expressed in hypothalamic neurons in the arcuate (ARC).
Kristie Conde +9 more
doaj +1 more source
GHSR deficiency suppresses neointimal formation in injured mouse arteries [PDF]
Biochemical and Biophysical Research Communications, 2016 Growth hormone secretagogue receptor (GHSR) is involved in appetite regulation and energy homeostasis. In the present study, we examined the role of GHSR in neointimal formation following vascular injury. In the mouse model of femoral artery wire injury, we found that vessel intima-to-media ratio was significantly reduced in GHSR deficiency (GHSR ...
Jing, Li +6 more
openaire +2 more sources
CJC Open, 2021 Background: The hormone ghrelin and its receptor, the growth hormone secretagogue receptor (GHSR) are expressed in myocardium. GHSR binding activates signalling pathways coupled to cardiomyocyte survival and contractility.
Rebecca Sullivan, BSc +7 more
doaj +1 more source