Results 21 to 30 of about 8,222 (228)

Ghrelin/GHSR System in Depressive Disorder: Pathologic Roles and Therapeutic Implications

Current Issues in Molecular Biology
Depression is the most common chronic mental illness and is characterized by low mood, insomnia, and affective disorders. However, its pathologic mechanisms remain unclear. Numerous studies have suggested that the ghrelin/GHSR system may be involved in the pathophysiologic process of depression.
Xingli Pan, Yuxin Gao, Kaifu Guan, Jing Chen, Bingyuan Ji   +4 more
openaire   +5 more sources

6789 Do Obesity-Associated MRAP2 Variants Modulate MC4R and GHSR Signaling?

Journal of the Endocrine Society
Abstract Disclosure: A.V. Rodriguez Rondon: None. F. Volker: None. M.S. Welling: None. C. de Groot: None. M.M. van Haelst: None. E.L. van den Akker: None. E.F. van Rossum: None. P.J. Delhanty: None. J.A. Visser: None. Melanocortin 2 receptor accessory protein 2 (MRAP2) is a membrane-bound protein expressed on hypothalamic ...
Rondon, Alejandra Virginia Rodriguez, Volker, Femke, Welling, Mila Sofie, de Groot, Corjan, van Haelst, Mieke M, van den Akker, Erica L T, van Rossum, Elisabeth F C, Delhanty, Patric John, Visser, Jenny A   +8 more
openaire   +2 more sources

Exploring the Relationship Between Growth Hormone Secretagogue Receptor (GHSR) Gene and Body Proportions in Bangkok Chickens: Insights from DNA Sequencing and Hin6I Enzyme-Restricted PCR-RFLP Analysis

Jurnal Medik Veteriner
The purpose of this study was to determine the diversity of the growth hormone secretagogue receptor (GHSR) gene and also to analyze the association of the GHSR gene with the body proportions of Bangkok chickens.
Gayuh Syaikhullah, Rosa Tri Hertamawati, M. Adhyatma   +2 more
openalex   +4 more sources

Short stature due to GHSR deficiency [PDF]

, 2020
INSERM
openaire   +2 more sources

Temporal control of eating and body weight by GHSR-expressing suprachiasmatic nucleus neurons

Cell Reports
Summary: Food consumption impacts body weight differently depending on the time of day. Here, we investigated whether suprachiasmatic nucleus (SCN) neurons responsive to the hormone ghrelin temporally regulate eating and body weight in mice.
Omprakash Singh, Sepideh Sheybani-Deloui, S K Kulkarni, Mingen Lyu, Bing Li, Salil Varshney, Kripa Shankar, Deepali Gupta, Luis Leon‐Mercado, Avi W Burstein, Corine P. Richard, Connor Lawrence, Sherri Osborne‐Lawrence, Jeffrey M. Zigman   +13 more
openalex   +3 more sources

Growth hormone secretagogue receptor‐1a mediates ghrelin's effects on attenuating tumour‐induced loss of muscle strength but not muscle mass

Journal of Cachexia, Sarcopenia and Muscle, 2021
Background Ghrelin may ameliorate cancer cachexia (CC) by preventing anorexia, muscle, and fat loss. However, the mechanisms mediating these effects are not fully understood. This study characterizes the pathways involved in muscle mass and strength loss
Haiming Liu, Pu Zang, Ian (In‐gi) Lee, Barbara Anderson, Anthony Christiani, Lena Strait‐Bodey, Beatrice A. Breckheimer, Mackenzie Storie, Alison Tewnion, Kora Krumm, Theresa Li, Brynn Irwin, Jose M. Garcia   +12 more
doaj   +1 more source

LEAP2 Impairs the Capability of the Growth Hormone Secretagogue Receptor to Regulate the Dopamine 2 Receptor Signaling

Frontiers in Pharmacology, 2021
The growth hormone secretagogue receptor (GHSR) signals in response to ghrelin, but also acts via ligand-independent mechanisms that include either constitutive activation or interaction with other G protein-coupled receptors, such as the dopamine 2 ...
Emilio R. Mustafá, Santiago Cordisco González, Marjorie Damian, Sonia Cantel, Severine Denoyelle, Renaud Wagner, Helgi B. Schiöth, Helgi B. Schiöth, Jean-Alain Fehrentz, Jean-Louis Banères, Mario Perelló, Jesica Raingo   +11 more
doaj   +1 more source

GHSR hypermethylation: a promising pan-cancer marker [PDF]

Cell Cycle, 2015
The advent of high-throughput technologies such as microarrays, global gene knockout, and next generation sequencing (NGS) has revolutionized the field of molecular oncology. Large-scale endeavors of the kind represented by the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA) are generating comprehensive portraits of ...
Pouria, Jandaghi, Jörg D, Hoheisel, Yasser, Riazalhosseini   +2 more
openaire   +2 more sources

Heritage Building Stones from Évora, Portugal [PDF]

, 2020
The city of Évora, a World Heritage Site recognized by UNESCO in 1986, also owes this recognition to the stones that built its monuments and preserve them until today. This work brings together the contributions that we have gathered over the past three
Lope, Luís
core   +1 more source

Deletion of Growth Hormone Secretagogue Receptor in Kisspeptin Neurons in Female Mice Blocks Diet-Induced Obesity

Biomolecules, 2022
The gut peptide, ghrelin, mediates energy homeostasis and reproduction by acting through its receptor, growth hormone secretagogue receptor (GHSR), expressed in hypothalamic neurons in the arcuate (ARC).
Kristie Conde, Danielle Kulyk, Allison Vanschaik, Sierra Daisey, Catherine Rojas, Kimberly Wiersielis, Ali Yasrebi, Thomas J. Degroat, Yuxiang Sun, Troy A. Roepke   +9 more
doaj   +1 more source