Results 31 to 40 of about 8,260 (216)
Biomolecules, 2022 Ghrelin receptor, a growth hormone secretagogue receptor (GHS-R), is expressed in the pancreas. Emerging evidence indicates that GHS-R is involved in the regulation of glucose-stimulated insulin secretion (GSIS), but the mechanism by which GHS-R ...
Geetali Pradhan +11 more
doaj +1 more source
Ghrelin-GHSR-LEAP2 system in the pathophysiology of type 2 diabetes. [PDF]
iSciencePu Y +9 more
europepmc +3 more sources
Science-Business eXchange, 2009 Swedish researchers have used compounds from Aeterna Zentaris and Ipsen Group to develop evidence that ghrelin inhibition could treat alcohol dependence, if the receptor can be targeted without adversely affecting appetite or body weight.
openaire +1 more source
Neuronal GHS-R Differentially Modulates Feeding Patterns under Normal and Obesogenic Conditions
Biomolecules, 2022 The orexigenic hormone ghrelin increases food intake and promotes obesity through its receptor, growth hormone secretagogue receptor (GHS-R). We previously reported two neuron-specific GHS-R knockout mouse lines, namely pan-neuronal deletion by Syn1-cre ...
Jong Han Lee +3 more
doaj +1 more source
Neuropeptide receptors as potential antiepileptic drug targets : focus on the ghrelin axis [PDF]
, 2014 Epilepsy is a very serious neurological disorder which is often underrepresented. Around 50 million individuals worldwide have active epilepsy with recurrent seizures and in spite of the medical advances over the years, 30% of these patients remain as ...
Portelli, Jeanelle
core +1 more source
Ghrelin Decreases Firing Activity of Gonadotropin-Releasing Hormone (GnRH) Neurons in an Estrous Cycle and Endocannabinoid Signaling Dependent Manner. [PDF]
, 2013 The orexigenic peptide, ghrelin is known to influence function of GnRH neurons, however, the direct effects of the hormone upon these neurons have not been explored, yet.
Farkas, Imre +3 more
core +2 more sources
Identification of piperazine-bisamide GHSR antagonists for the treatment of obesity
Bioorganic & Medicinal Chemistry Letters, 2010 Piperazine-bisamide analogs were discovered as partial agonists of human growth hormone secretagogue receptor (GHSR) in a high throughput screen. The partial agonists were optimized for potency and converted into antagonists through structure-activity relationship (SAR) studies.
Ming Yu +14 more
openalex +3 more sources
Molecular Metabolism, 2017 Objective: Ghrelin is a stomach-derived hormone that affects food intake and regulates blood glucose. The best-characterized actions of ghrelin are mediated by its binding to and activation of the growth hormone secretagogue receptor (GHSR; ghrelin ...
Bharath K. Mani +6 more
doaj +1 more source
Molecular Metabolism, 2021 Objective: Acyl-ghrelin regulates eating, body weight, blood glucose, and GH secretion upon binding to its receptor GHSR (growth hormone secretagogue receptor; ghrelin receptor). GHSR is distributed in several brain regions and some peripheral cell-types
Deepali Gupta +11 more
doaj +1 more source
Ghrelin axis genes, peptides and receptors : recent findings and future challenges [PDF]
, 2011 The ghrelin axis consists of the gene products of the ghrelin gene (GHRL), and their receptors, including the classical ghrelin receptor GHSR. While it is well-known that the ghrelin gene encodes the 28 amino acid ghrelin peptide hormone, it is now also ...
Seim, Inge +4 more
core +2 more sources