Results 31 to 40 of about 8,222 (228)

GHSR deficiency suppresses neointimal formation in injured mouse arteries [PDF]

Biochemical and Biophysical Research Communications, 2016
Growth hormone secretagogue receptor (GHSR) is involved in appetite regulation and energy homeostasis. In the present study, we examined the role of GHSR in neointimal formation following vascular injury. In the mouse model of femoral artery wire injury, we found that vessel intima-to-media ratio was significantly reduced in GHSR deficiency (GHSR ...
Jing, Li, Man, Zhang, Mo, Wang, Zhipeng, Wang, Yahan, Liu, Weizhen, Zhang, Nanping, Wang   +6 more
openaire   +2 more sources

Mechanistic Investigation of GHS-R Mediated Glucose-Stimulated Insulin Secretion in Pancreatic Islets

Biomolecules, 2022
Ghrelin receptor, a growth hormone secretagogue receptor (GHS-R), is expressed in the pancreas. Emerging evidence indicates that GHS-R is involved in the regulation of glucose-stimulated insulin secretion (GSIS), but the mechanism by which GHS-R ...
Geetali Pradhan, Jong Han Lee, Chia-Shan Wu, Hongying Wang, Ligen Lin, Taraka Donti, Brett H. Graham, Arun S. Rajan, Ashok Balasubramanyam, Susan L. Samson, Shaodong Guo, Yuxiang Sun   +11 more
doaj   +1 more source

Depending on GHSR [PDF]

Science-Business eXchange, 2009
Swedish researchers have used compounds from Aeterna Zentaris and Ipsen Group to develop evidence that ghrelin inhibition could treat alcohol dependence, if the receptor can be targeted without adversely affecting appetite or body weight.
openaire   +1 more source

Regional Differences in the Ghrelin-Growth Hormone Secretagogue Receptor Signalling System in Human Heart Disease

CJC Open, 2021
Background: The hormone ghrelin and its receptor, the growth hormone secretagogue receptor (GHSR) are expressed in myocardium. GHSR binding activates signalling pathways coupled to cardiomyocyte survival and contractility.
Rebecca Sullivan, BSc, Varinder K. Randhawa, PhD, MD, Tyler Lalonde, PhD, Tina Yu, BSc, Bob Kiaii, MD, Leonard Luyt, PhD, Gerald Wisenberg, MD, Savita Dhanvantari, PhD   +7 more
doaj   +1 more source

Neuronal GHS-R Differentially Modulates Feeding Patterns under Normal and Obesogenic Conditions

Biomolecules, 2022
The orexigenic hormone ghrelin increases food intake and promotes obesity through its receptor, growth hormone secretagogue receptor (GHS-R). We previously reported two neuron-specific GHS-R knockout mouse lines, namely pan-neuronal deletion by Syn1-cre ...
Jong Han Lee, Bingzhong Xue, Zheng Chen, Yuxiang Sun   +3 more
doaj   +1 more source

Midbrain ghrelin receptor signalling regulates binge drinking in a sex specific manner. [PDF]

Nat Commun
Risky drinking rates are rising, particularly in women, yet sex as a biological variable has only recently gained traction. The centrally projecting Edinger-Westphal (EWcp) nucleus has emerged as a key regulator of alcohol consumption. Here we found that
Pearl AJ, Maddern XJ, Pinares-Garcia P, Ursich LT, Anversa RG, Shesham A, Brown RM, Reed FM, Giardino WJ, Lawrence AJ, Walker LC.   +10 more
europepmc   +2 more sources

Neuropeptide receptors as potential antiepileptic drug targets : focus on the ghrelin axis [PDF]

, 2014
Epilepsy is a very serious neurological disorder which is often underrepresented. Around 50 million individuals worldwide have active epilepsy with recurrent seizures and in spite of the medical advances over the years, 30% of these patients remain as ...
Portelli, Jeanelle
core   +1 more source

Ghrelin Decreases Firing Activity of Gonadotropin-Releasing Hormone (GnRH) Neurons in an Estrous Cycle and Endocannabinoid Signaling Dependent Manner. [PDF]

, 2013
The orexigenic peptide, ghrelin is known to influence function of GnRH neurons, however, the direct effects of the hormone upon these neurons have not been explored, yet.
Farkas, Imre, Liposits, Zsolt, Sárvári, Miklós, Vastagh, Csaba   +3 more
core   +2 more sources

The role of ghrelin-responsive mediobasal hypothalamic neurons in mediating feeding responses to fasting

Molecular Metabolism, 2017
Objective: Ghrelin is a stomach-derived hormone that affects food intake and regulates blood glucose. The best-characterized actions of ghrelin are mediated by its binding to and activation of the growth hormone secretagogue receptor (GHSR; ghrelin ...
Bharath K. Mani, Sherri Osborne-Lawrence, Mathieu Mequinion, Sydney Lawrence, Laurent Gautron, Zane B. Andrews, Jeffrey M. Zigman   +6 more
doaj   +1 more source

The G protein-coupled receptor heterodimer network (GPCR-HetNet) and its hub components [PDF]

, 2014
G protein-coupled receptors (GPCRs) oligomerization has emerged as a vital characteristic of receptor structure. Substantial experimental evidence supports the existence of GPCR-GPCR interactions in a coordinated and cooperative manner.
Agnati, Luigi F, Borroto-Escuela, Dasiel O, Brito, Ismel, Di Palma, Michael, Duchou, Jolien, Fuxe, Kjell, Guidolin, Diego, Oflijan, Julia, Rivera, Alicia, Romero-Fernandez, Wilber, Skieterska, Kamila, Suárez-Boomgaard, Diana, Van Craenenbroeck, Kathleen   +12 more
core   +4 more sources