GHS-R1a Deficiency Alleviates Depression-Related Behaviors After Chronic Social Defeat Stress
Frontiers in Neuroscience, 2019 Ghrelin is an important orexigenic hormone that regulates feeding, metabolism and glucose homeostasis in human and rodents. Ghrelin functions by binding to its receptor, the growth hormone secretagogue receptor 1a (GHS-R1a), which is widely expressed ...
Li Guo +12 more
doaj +1 more source
Ghrelin axis genes, peptides and receptors : recent findings and future challenges [PDF]
, 2011 The ghrelin axis consists of the gene products of the ghrelin gene (GHRL), and their receptors, including the classical ghrelin receptor GHSR. While it is well-known that the ghrelin gene encodes the 28 amino acid ghrelin peptide hormone, it is now also ...
Seim, Inge +4 more
core +2 more sources
Ghrelin/GHSR System in Depressive Disorder: Pathologic Roles and Therapeutic Implications
Current Issues in Molecular BiologyDepression is the most common chronic mental illness and is characterized by low mood, insomnia, and affective disorders. However, its pathologic mechanisms remain unclear. Numerous studies have suggested that the ghrelin/GHSR system may be involved in the pathophysiologic process of depression.
Xingli Pan +4 more
openalex +4 more sources
Diabetology & Metabolic Syndrome, 2023 Introduction The transition to metabolically unhealthy obesity (MUO) is driven by the limited expandability of adipose tissue (AT). Familial Partial Lipodystrophy type 2 (FPLD2) is an alternative model for AT dysfunction that is suitable for comparison ...
Guillaume Treiber +7 more
doaj +1 more source
A low cost shading analyzer and site evaluator design to determine solar power system installation area [PDF]
, 2015 Shading analyzer systems are necessary for selecting the most suitable installation site to sustain enough solar power. Afterwards, changes in solar data throughout the year must be evaluated along with the identification of obstructions surrounding the ...
Dinçer, Furkan +5 more
core +1 more source
Functional and Neurochemical Identification of Ghrelin Receptor (GHSR)-Expressing Cells of the Lateral Parabrachial Nucleus in Mice [PDF]
Frontiers in Neuroscience, 2021 The lateral parabrachial nucleus (lPBN), located in the pons, is a well-recognized anorexigenic center harboring, amongst others, the calcitonin gene-related peptide (CGRP)-expressing neurons that play a key role. The receptor for the orexigenic hormone ghrelin (the growth hormone secretagogue receptor, GHSR) is also abundantly expressed in the lPBN ...
Erik Schéle +7 more
openaire +4 more sources
Cambrian age Welsh slate: a global heritage stone resource from the United Kingdom [PDF]
, 2016 Slate from the Cambrian succession of North Wales is a well-known source of building products from the United Kingdom and is here advocated as a suitable “Global Heritage Stone Resource”.
Horak, Jana +3 more
core +1 more source
Intestinal expression profiles and hepatic expression of LEAP2, ghrelin and their common receptor, GHSR, in humans [PDF]
PeptidesLiver-expressed antimicrobial peptide 2 (LEAP2) and ghrelin have reciprocal effects on their common receptor, the growth hormone secretagogue receptor (GHSR). Ghrelin is considered a gastric hormone and LEAP2 a liver-derived hormone and both have been proposed to be involved in the pathophysiology of obesity and type 2 diabetes (T2D).
Anders Englund +5 more
openalex +4 more sources
Genetic determination of the cellular basis of the ghrelin-dependent bone remodeling
Molecular Metabolism, 2015 Objective: Bone mass is maintained through a balance of bone formation and resorption. This homeostatic balance is regulated by various systems involving humoral and local factors.
Chengshan Ma +7 more
doaj +1 more source
Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity. [PDF]
PLoS ONE, 2010 The growth hormone secretagogue receptor (GHSR) is mediating hunger sensation when stimulated by its natural ligand ghrelin. In the present study, we tested the hypothesis that common and rare variation in the GHSR locus are related to increased ...
Anette P Gjesing +20 more
doaj +1 more source