Machine Learning for Predictive Modeling in Nanomedicine‐Based Cancer Drug Delivery
Med Research, EarlyView.The integration of AI/ML into nanomedicine offers a transformative approach to therapeutic design and optimization. Unlike conventional empirical methods, AI/ML models (such as classification, regression, and neural networks) enable the analysis of complex clinical and formulation datasets to predict optimal nanoparticle characteristics and therapeutic
Rohan Chand Sahu +3 more
wiley +1 more source
Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel [PDF]
, 2019 Pentameric ligand-gated ion channels (pLGICs) are essential determinants of synaptic transmission, and are modulated by specific lipids including anionic phospholipids.
Brannigan, Grace +7 more
core +1 more source
Formation of unilamellar dipalmitoylphosphatidylcholine vesicles promoted by Ca2+ ions: A small-angle neutron scattering study [PDF]
, 2007 Dipalmitoylphosphatidylcholine (DPPC) was hydrated in 0.2-60 mM solution of CaCl 2 in heavy water and thoroughly homogenized by freezing-thawing process.
Almásy, László +3 more
core +1 more source
Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment
Rare Metals, EarlyView.ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang +9 more
wiley +1 more source
Compartmentalization and Transport in Synthetic Vesicles
Frontiers in Bioengineering and Biotechnology, 2016 Nano-scale vesicles have become a popular tool in life sciences. Besides liposomes that are generated from phospholipids of natural origin, polymersomes fabricated of synthetic block copolymers enjoy increasing popularity, as they represent more ...
Christine eSchmitt +4 more
doaj +1 more source
Solvent‐Mediated Dewetting Principles for Cell‐Sized Liposome Formation
Small, EarlyView.Dynamics of solvent‐mediated dewetting for giant unilamellar liposome formation. Solvent removal, through changing lipid packing and membrane tension, is shown to induce partial dewetting into equilibrium low and high budding angle morphologies. Complete dewetting requires mechanical force, quantified using optical tweezers.
Mostafa Bakouei +6 more
wiley +1 more source
Mechanical response of adherent giant liposomes to indentation with a conical AFM-tip.
Soft Matter, 2015 Indentation of giant liposomes with a conical indenter is described by means of a tension-based membrane model. We found that nonlinear membrane theory neglecting the impact of bending sufficiently describes the mechanical response of liposomes to ...
Edith Schäfer +3 more
semanticscholar +1 more source
PharmaceuticsNanovesicles produced with lipids and polymers are promising devices for drug and bioactive delivery and are of great interest in pharmaceutical applications.
Patrick D. Mathews +7 more
doaj +1 more source
Novel directions in molecular systems design: The case of light-transducing synthetic cells
Communicative & Integrative Biology, 2017 Important progresses have been achieved in the past years in the field of bottom-up synthetic biology, especially aiming at constructing cell-like systems based on lipid vesicles (liposomes) entrapping both biomolecules or synthetic compounds.
Pasquale Stano +2 more
doaj +1 more source
Heat-induced formation of single giant unilamellar vesicles [PDF]
, 2011 Giant unilamellar vesicles (GUVs) are an excellent model system for the investigation of lipid membranes, the study of membrane proteins and ion channels in a biomimetic environment, and in the creation of artificial cells.
Billerit, Celine +5 more
core +1 more source