Results 51 to 60 of about 5,077 (168)

β‐Ketonitrile‐Modified Prodan Derivatives as Large‐Stokes‐Shift Solvatochromic Fluorophores With Enhanced Brightness and Ratiometric Thermometric Response

Chemistry – A European Journal, EarlyView.
We report a systematic study of β‐ketonitrile–modified Prodan‐type solvatochromic fluorophores. The β‐ketonitrile substitution induces marked bathochromic shifts in absorption and emission and significantly enhances fluorescence quantum yields in nonpolar solvents.
Hiroaki Asakawa, Takuya Tanaka, Kensei Konishi, Gen‐ichi Konishi   +3 more
wiley   +1 more source

Uniform Microscale Thermoresponsive Liposomes for Controlled Release Above Body Temperature

Small, EarlyView.
Uniform thermoresponsive liposomes are generated using a scalable double‐emulsion microfluidic approach coupled with accelerated solvent extraction. The resulting liposomes remain stable at physiological temperature but undergo abrupt rupture and cargo release at 41°C–45°C, providing a versatile platform for thermally triggered controlled release in ...
S. Morteza Mousavi, Yang Zhang, Elvis Pandzic, David W. Inglis, Megan S. Lord, Robert A. Taylor, Ming Li   +6 more
wiley   +1 more source

The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment

eLife, 2020
The selective autophagy pathways of xenophagy and mitophagy are initiated when the adaptor NDP52 recruits the ULK1 complex to autophagic cargo. Hydrogen-deuterium exchange coupled to mass spectrometry (HDX-MS) was used to map the membrane and NDP52 ...
Xiaoshan Shi, Chunmei Chang, Adam L Yokom, Liv E Jensen, James H Hurley   +4 more
doaj   +1 more source

Cholesterols Work as a Molecular Regulator of the Antimicrobial Peptide-Membrane Interactions

Frontiers in Molecular Biosciences, 2021
The existing cholesterols (Chols) in animal cell membranes play key roles in many fundamental cellular processes, which also promise the possibility to modulate the bioactivity of various membrane-active biomacromolecules.
Jia Li, Xuemei Lu, Xuemei Lu, Wendong Ma, Zhonglan Chen, Shuqing Sun, Qinghui Wang, Bing Yuan, Kai Yang   +8 more
doaj   +1 more source

Reduced colony‐stimulating factor 1 receptor expression in myeloid cells has limited impact on chronic lymphocytic leukaemia progression

British Journal of Haematology, EarlyView.
Summary Targeting the colony‐stimulating factor 1 receptor (CSF1R) to remove tumour‐associated macrophages is being explored as cancer therapy. This strategy may be relevant for chronic lymphocytic leukaemia (CLL), which strongly depends on support from myeloid cells.
Natascha Rosen, Guillermo Rodriguez‐Real, Alexander F. vom Stein, Luca D. Schreurs, Trong‐Hieu Nguyen, Viktoria Kohlhas, Thanh‐Tung Truong, Maximilian Koch, Sebastian Reinartz, Sumiya Iqbal, Shaista Ilyas, Sanjay Mathur, Nina Reinart, Phuong‐Hien Nguyen, Michael Hallek   +14 more
wiley   +1 more source

Wrapping Pathways of Anisotropic Dumbbell Particles by Giant Unilamellar Vesicles

Nano Letters, 2023
Endocytosis is a key cellular process involved in the uptake of nutrients, pathogens or the diagnosis and therapy of diseases. Most studies have focused on spherical objects, whereas biologically relevant shapes can be highly anisotropic. In this letter, we use an experimental model system based on Giant Unilamellar Vesicles (GUVs) and dumbbell-shaped ...
Azadbakht, Ali, Meadowcroft, Billie, Varkevisser, Thijs, Šarić, Anđela, Kraft, Daniela J.   +4 more
openaire   +5 more sources

Efficacy Assessment of Montanide GEL 02 PR and Liposome‐Based Encapsulation as Adjuvants for an FrpA Subunit Vaccine Against Photobacteriosis in Solea senegalensis

Journal of Fish Diseases, EarlyView.
ABSTRACT Photobacteriosis is a major threat to marine aquaculture, and the siderophore transporter FrpA represents a promising target for effective subunit vaccine development. In this study, we evaluated Montanide GEL 02 PR and phosphatidylcholine‐based liposomes as aqueous and safer alternatives to Freund's adjuvant for an FrpA‐based subunit vaccine ...
Marta A. Lages, Miguel Balado, Abel M. Forero, Lucía Ageitos, Jaime Rodríguez, Carlos Jiménez, Manuel L. Lemos, Beatriz Magariños   +7 more
wiley   +1 more source

Taming membranes: functional immobilization of biological membranes in hydrogels. [PDF]

PLoS ONE, 2011
Single molecule studies on membrane proteins embedded in their native environment are hampered by the intrinsic difficulty of immobilizing elastic and sensitive biological membranes without interfering with protein activity.
Ilja Kusters, Nobina Mukherjee, Menno R de Jong, Sander Tans, Armağan Koçer, Arnold J M Driessen   +5 more
doaj   +1 more source

Tuning Membrane Binding and Lipid Phase Preference of DNA Nanostructures via Synergistic Multi‐Lipidation

ChemSystemsChem, Volume 8, Issue 5, September 2026.
DNA origami nanostructures functionalized with lipophilic anchors of distinct hydrophobicity reveal synergistic effects on membrane binding and phase‐specific localization. Weak anchors, although insufficient for binding alone, enhance membrane association and govern selective phase partitioning when combined with strong anchors, establishing multi ...
Subhasini Singh, Henri G. Franquelim
wiley   +1 more source

A membrane filtering method for the purification of giant unilamellar vesicles

Chemistry and Physics of Lipids, 2011
The use of giant unilamellar vesicles (GUVs) for investigating the properties of biomembranes is advantageous compared to the use of small-sized vesicles such as large unilamellar vesicles (LUVs). Experimental methods using GUVs, such as the single GUV method, would benefit if there was a methodology for obtaining a large population of similar-sized ...
Yukihiro, Tamba, Hiroaki, Terashima, Masahito, Yamazaki   +2 more
openaire   +2 more sources