A giant virus infecting the amoeboflagellate Naegleria. [PDF]
Nat CommunGiant viruses (Nucleocytoviricota) are significant lethality agents of various eukaryotic hosts. Although metagenomics indicates their ubiquitous distribution, available giant virus isolates are restricted to a very small number of protist and algal ...
Arthofer P +12 more
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Giant virus diversity and host interactions through global metagenomics. [PDF]
Nature, 2020 Our current knowledge about nucleocytoplasmic large DNA viruses (NCLDVs) is largely derived from viral isolates that are co-cultivated with protists and algae.
Schulz F +10 more
europepmc +7 more sources
Near-atomic structure of a giant virus. [PDF]
Nat Commun, 2019 Although the nucleocytoplasmic large DNA viruses (NCLDVs) are one of the largest group of viruses that infect many eukaryotic hosts, the near-atomic resolution structures of these viruses have remained unknown.
Fang Q +11 more
europepmc +6 more sources
Giant variations in giant virus genome packaging.
Trends in Biochemical Sciences, 2023 Giant viruses (Nucleocytoviricota) have a largely conserved lifecycle, yet how they cram their large genomes into viral capsids is mostly unknown. The major capsid protein and the packaging ATPase (pATPase) comprise a highly conserved morphogenesis ...
P. Talbert, S. Henikoff, K. Armache
semanticscholar +3 more sources
Clandestinovirus: A Giant Virus With Chromatin Proteins and a Potential to Manipulate the Cell Cycle of Its Host Vermamoeba vermiformis. [PDF]
Front Microbiol, 2021 For several decades, the vast world of DNA viruses has been expanding constantly. Various discoveries in this field have broadened our knowledge and revealed that DNA viruses encode many functional features, which were once thought to be exclusive to ...
Rolland C +5 more
europepmc +2 more sources
ViralRecall-A Flexible Command-Line Tool for the Detection of Giant Virus Signatures in 'Omic Data. [PDF]
Viruses, 2021 Giant viruses are widespread in the biosphere and play important roles in biogeochemical cycling and host genome evolution. Also known as Nucleo-Cytoplasmic Large DNA Viruses (NCLDV), these eukaryotic viruses harbor the largest and most complex viral ...
Aylward FO, Moniruzzaman M.
europepmc +2 more sources
Endogenous virophages are active and mitigate giant virus infection in the marine protist Cafeteria burkhardae. [PDF]
Proc Natl Acad Sci U S ASignificance Single-celled eukaryotes are parasitized by viruses just like other life forms, but compared to bacteria or animals, their defense systems against viral infection remain unknown.
Koslová A +7 more
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Conservative taxonomy and quality assessment of giant virus genomes with GVClass. [PDF]
Npj VirusesBackground Large double-stranded DNA viruses of the phylum Nucleocytoviricota (Giant viruses; GVs) include the largest known viruses, both in terms of capsid and genome size and are associated with a wide range of eukaryotic hosts.
Pitot TM, Brůna T, Schulz F.
europepmc +2 more sources
Revisiting giant virus-host dynamics in brown algae: old stories and new perspectives [PDF]
The EMBO JournalThe recent discovery of widespread giant virus sequences integrated into the genomes of diverse eukaryotes, and in particular marine lineages, has reignited interest in the molecular mechanisms underlying giant virus–host interactions.
Carole Duchêne +2 more
doaj +2 more sources
Advantages and Limits of Metagenomic Assembly and Binning of a Giant Virus. [PDF]
mSystems, 2020 The discovery of large and giant nucleocytoplasmic large DNA viruses (NCLDV) with genomes in the megabase range and equipped with a wide variety of features typically associated with cellular organisms was one of the most unexpected, intriguing, and ...
Schulz F +7 more
europepmc +2 more sources