Results 31 to 40 of about 41,746 (235)
Naiavirus: an enveloped giant virus with a pleomorphic, flexible tail. [PDF]
Nat CommunNumerous studies have shown that viruses are present in a variety of environments on Earth, acting as drivers of biogeochemical cycles and powerful selective forces. Among them, giant viruses of amoebae have garnered attention from the scientific community due to their large particles and extensive genomes. Here, we describe the discovery of one of the
Rodrigues M +20 more
europepmc +4 more sources
Cryptic infection of a giant virus in a unicellular green alga. [PDF]
ScienceLatency is a common strategy in a wide range of viral lineages, but its prevalence in giant viruses remains unknown. In this work, we describe a 617–kilo–base pairs integrated giant viral element in the model green alga Chlamydomonas reinhardtii .
Erazo-Garcia MP +12 more
europepmc +7 more sources
Frontiers in Microbiology, 2020 Viruses modulate the function(s) of environmentally relevant microbial populations, yet considerations of the metabolic capabilities of individual virus particles themselves are rare. We used shotgun proteomics to quantitatively identify 43 virus-encoded
Eric R. Gann +6 more
doaj +1 more source
A Brief History of Giant Viruses’ Studies in Brazilian Biomes
Viruses, 2022 Almost two decades after the isolation of the first amoebal giant viruses, indubitably the discovery of these entities has deeply affected the current scientific knowledge on the virosphere. Much has been uncovered since then: viruses can now acknowledge
Paulo Victor M. Boratto +16 more
doaj +1 more source
Identification of giant Mimivirus protein functions using RNA interference
Frontiers in Microbiology, 2015 Genomic analysis of giant viruses, such as Mimivirus, has revealed that more than half of the putative genes have no known functions (ORFans). We knocked down Mimivirus genes using short interfering RNA (siRNA) as a proof of concept to determine the ...
Haitham eSobhy +7 more
doaj +1 more source
An Update on Eukaryotic Viruses Revived from Ancient Permafrost
Viruses, 2023 One quarter of the Northern hemisphere is underlain by permanently frozen ground, referred to as permafrost. Due to climate warming, irreversibly thawing permafrost is releasing organic matter frozen for up to a million years, most of which decomposes ...
Jean-Marie Alempic +11 more
doaj +1 more source
A Brazilian Marseillevirus Is the Founding Member of a Lineage in Family Marseilleviridae
Viruses, 2016 In 2003, Acanthamoeba polyphaga mimivirus (APMV) was discovered as parasitizing Acanthamoeba. It was revealed to exhibit remarkable features, especially odd genomic characteristics, and founded viral family Mimiviridae.
Fábio P. Dornas +6 more
doaj +1 more source
eLife, 2022 Mimivirus is the prototype of the Mimiviridae family of giant dsDNA viruses. Little is known about the organization of the 1.2 Mb genome inside the membrane-limited nucleoid filling the ~0.5 µm icosahedral capsids. Cryo-electron microscopy, cryo-electron
Alejandro Villalta +13 more
doaj +1 more source
New Brazilian giant viruses isolation from environmental samples using a panel of protozoa.
Frontiers in Microbiology, 2015 The Megavirales are a newly described order capable of infecting different types of eukaryotic hosts. For the most part, the natural host is unknown.
Fábio Pio Dornas +6 more
doaj +1 more source
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source