Results 1 to 10 of about 2,402 (156)

Gingipains protect Porphyromonas gingivalis from macrophage-mediated phagocytic clearance. [PDF]

PLoS Pathogens
Porphyromonas gingivalis (Pg) is a keystone pathogen in periodontitis, a highly prevalent disease manifested by chronic inflammation of the periodontium, alveolar bone resorption and tooth loss.
Magdalena Widziolek, Anna Mieszkowska, Magdalena Marcinkowska, Bartlomiej Salamaga, Justyna Folkert, Krzysztof Rakus, Magdalena Chadzinska, Jan Potempa, Graham P Stafford, Tomasz K Prajsnar, Craig Murdoch   +10 more
doaj   +5 more sources

Gingipains disrupt bone homeostasis via dual regulation of osteogenesis and osteoclastogenesis through exosomal miR-146a-5p/TRAF6 signaling [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundGingipains are virulence factors released by Porphyromonas gingivalis that contribute to periodontal destruction by disrupting bone metabolism.
Jiachen Dong, Jiachen Dong, Jiachen Dong, Yue Liao, Yue Liao, Yue Liao, Mengjun Sun, Mengjun Sun, Mengjun Sun, Huiwen Chen, Huiwen Chen, Huiwen Chen, Kecong Zhou, Kecong Zhou, Kecong Zhou, Huanyu Zhang, Huanyu Zhang, Huanyu Zhang, Wei Zhou, Wei Zhou, Wei Zhou, Zhongchen Song, Zhongchen Song, Zhongchen Song   +23 more
doaj   +2 more sources

Discovery of Gingipains and Porphyromonas gingivalis Inhibitors from Food-Derived Natural Products: A Narrative Review [PDF]

Foods
Porphyromonas gingivalis is a key periodontal pathogen whose cysteine proteases, gingipains (Rgp and KGP), are essential for nutrient acquisition and virulence.
Desheng Wu, Xiaofeng Li, Guanglei Zhao, Lisha Hao, Xiaohan Liu   +4 more
doaj   +2 more sources

The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease. [PDF]

J Intern Med
Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Barron AE, Lin JS, Ryder MI, Bergman P.
europepmc   +2 more sources

Porphyromonas gingivalis affects neutrophil pro-inflammatory activities [PDF]

Frontiers in Cell and Developmental Biology
Porphyromonas gingivalis is the primary pathogen responsible for the development of periodontal inflammatory disease. Although gingipains are the major virulence factor of the pathogen, their role in impairing apoptosis and immune cell function is not ...
Agnieszka Zimny, Alicja Płonczyńska, Alicja Płonczyńska, Wiktor Jakubowski, Natalia Zubrzycka, Natalia Zubrzycka, Jan Potempa, Jan Potempa, Maja Sochalska   +8 more
doaj   +2 more sources

The Interface of Oral and Brain Health: Current Insights Into the Bidirectional Relationship Between Alzheimer's Disease and Periodontitis. [PDF]

CNS Neurosci Ther
Bidirectional Pathogenesis Between AD and Periodontitis. Periodontal pathogens reach the brain via hematogenous/trigeminal/oral–intestinal pathways, triggering neuroinflammation and Aβ plaques to drive AD. Conversely, AD disrupts bone homeostasis (via Aβ, endocrine/autonomic dysregulation) to aggravate periodontitis.
Zhang W, Li S, Cui Y, Lun Y, Liu H, Li M.   +5 more
europepmc   +2 more sources

Porphromonas gingivalis infection induces gingipain-dependent changes in the brain vasculature of zebrafish larvae [PDF]

Cell Communication and Signaling
Recent studies link infections with blood–brain barrier (BBB) dysfunctions, neuroinflammation and subsequent neurodegeneration. Here, we employed a zebrafish larval model to study the impact of systemic infection with an oral pathogen Porphyromonas ...
Anna Mieszkowska, Magdalena Marcinkowska, Magdalena Widziolek, Jan Potempa, Magdalena Chadzinska   +4 more
doaj   +2 more sources

Alzheimer’s Disease and Porphyromonas gingivalis: Exploring the Links [PDF]

Life
Recent research highlights compelling links between oral health, particularly periodontitis, and systemic diseases, including Alzheimer’s disease (AD).
Ivana Shawkatova, Vladimira Durmanova, Juraj Javor   +2 more
doaj   +2 more sources

PGN_0298 in the Assembly and Insertion Machinery (Aim) Operon Is Essential for the Viability of Porphyromonas gingivalis. [PDF]

Microbiol Immunol
ABSTRACT Porphyromonas gingivalis is a typical periodontal pathogen, and one of its key virulence factors is the powerful protease gingipains. Gingipains are secreted via the type IX secretion system (T9SS) and are associated with the assembly and insertion machinery (Aim) operon (PGN_0296 to PGN_0301), which encodes both T9SS components and non‐T9SS ...
Ono S, Takebe K, Tosa I, Nishiya Y, Nakayama M, Wada T, Takashiba S, Ohara N.   +7 more
europepmc   +2 more sources

Ozone ultrafine bubble water sterilizes Porphyromonas gingivalis and neutralizes its virulence factors. [PDF]

PLoS ONE
Periodontitis is caused by Gram-negative bacteria. Porphyromonas gingivalis, a major Gram-negative periodontal pathogen, produces virulence factors such as gingipains, lipopolysaccharide (LPS), and lipoproteins, which contribute to tissue destruction ...
Mana Endo, Hisanori Domon, Satoru Hirayama, Fumio Takizawa, Akiomi Ushida, Koichi Tabeta, Yutaka Terao   +6 more
doaj   +2 more sources