Results 11 to 20 of about 2,402 (156)

Arginine-specific gingipains (RgpA/RgpB) knockdown modulates neutrophil machinery

Journal of Oral Microbiology
Background Gingipains are important virulence factors present in Porphyromonas gingivalis. Arginine-specific gingipains (RgpA and RgpB) are critically associated with increased proteolytic activity and immune system dysfunction, including neutrophilic ...
Vanessa Tubero Euzebio Alves, Tomaz Alves, Emanuel Silva Rovai, Hatice Hasturk, Thomas Van Dyke, Marinella Holzhausen, Alpdogan Kantarci   +6 more
doaj   +3 more sources

Comparative properties of envelope-associated arginine-gingipains and lysine-gingipain ofPorphyromonas gingivalis [PDF]

FEMS Microbiology Letters, 1998
Two arginine specific proteinases (Arg-gingipain [RGP-A, RGP-B]) and a lysine specific proteinase (Lys-gingipain [KGP]) were purified from materials of the envelope of Porphyromonas gingivalis solubilized by a detergent by the sequential procedures of ion-exchange chromatography, affinity chromatography, and isoelectric focusing.
S, Fujimura, K, Hirai, Y, Shibata, K, Nakayama, T, Nakamura   +4 more
openaire   +3 more sources

Development of a Simple Protocol for Zymogram-Based Isolation and Characterization of Gingipains from Porphyromonas gingivalis: The Causative Agent of Periodontitis

Applied Sciences, 2023
Gingipains (RgpA, RgpB, and Kgp) are major virulence factors of the periodontitis-causing bacterium Porphyromonas gingivalis. Isolation of gingipains from the crude protein sample of P.
Eng Sze Wei, Ramasamy Kavitha, Mohammad Auwal Sa’ad, Pattabhiraman Lalitha, Neeraj Kumar Fuloria, Manickam Ravichandran, Shivkanya Fuloria   +6 more
doaj   +1 more source

Proteolytic Activity-Independent Activation of the Immune Response by Gingipains from Porphyromonas gingivalis

mBio, 2022
Porphyromonas gingivalis, a keystone pathogen in periodontitis (PD), produces cysteine proteases named gingipains (RgpA, RgpB, and Kgp), which strongly affect the host immune system.
Izabela Ciaston, Joanna Budziaszek, Dorota Satala, Barbara Potempa, Andrew Fuchs, Maria Rapala-Kozik, Danuta Mizgalska, Ewelina Dobosz, Richard J. Lamont, Jan Potempa, Joanna Koziel   +10 more
doaj   +1 more source

Porphyromonas gingivalis bacterium as a risk factor for Alzheimer’s disease! [PDF]

Novel Research in Microbiology Journal, 2023
Alzheimer’s disease remains a significant socio-economic problem in modern medicine. This disease is a neurodegenerative one that is characterized by the plaque formation and neurofibrillary tangles, due to the accumulation of β-amyloid peptide in the ...
Andrei V. Kozlov, Artem V. Lyamin, Aleksei A. Neilenko, Anna V. Yanchenko, Alena A. Ereshchenko   +4 more
doaj   +1 more source

Gingipain aminopeptidase activities in Porphyromonas gingivalis [PDF]

bchm, 2012
Abstract Bestatin, a specific inhibitor of metalloaminopeptidases, inhibits the growth of Porphyromonas gingivalis. To identify its target enzyme, a library of fluorescent substrates was used but no metalloaminopeptidase activity was found. The aminopeptidase activity of P.
Florian Veillard, Barbara Potempa, Marcin Poreba, Marcin Drag, Jan Potempa   +4 more
openaire   +3 more sources

Coating and Corruption of Human Neutrophils by Bacterial Outer Membrane Vesicles

Microbiology Spectrum, 2022
Porphyromonas gingivalis is a keystone oral pathogen that successfully manipulates the human innate immune defenses, resulting in a chronic proinflammatory state of periodontal tissues and beyond.
Marines du Teil Espina, Yanyan Fu, Demi van der Horst, Claudia Hirschfeld, Marina López-Álvarez, Lianne M. Mulder, Costanza Gscheider, Anna Haider Rubio, Minke Huitema, Dörte Becher, Peter Heeringa, Jan Maarten van Dijl   +11 more
doaj   +1 more source

Proteolysis of Gingival Keratinocyte Cell Surface Proteins by Gingipains Secreted From Porphyromonas gingivalis – Proteomic Insights Into Mechanisms Behind Tissue Damage in the Diseased Gingiva

Frontiers in Microbiology, 2020
Porphyromonas gingivalis, the main etiologic agent of periodontitis, secretes cysteine proteases named gingipains. HRgpA and RgpB gingipains have Arg-specificity, while Kgp gingipain is Lys-specific.
Katarina Hočevar, Katarina Hočevar, Matej Vizovišek, Alicia Wong, Joanna Kozieł, Marko Fonović, Barbara Potempa, Richard J. Lamont, Jan Potempa, Jan Potempa, Boris Turk, Boris Turk   +11 more
doaj   +1 more source

Porphyromonas gingivalis-Helicobacter pylori co-incubation enhances Porphyromonas gingivalis virulence and increases migration of infected human oral keratinocytes

Journal of Oral Microbiology, 2022
Background Porphyromonas gingivalis is part of the subgingival biofilm and a keystone species in the development of periodontitis. Interactions between P.gingivalis and other bacteria in biofilms have been shown to affect bacterial virulence ...
Cristopher Soto, Victoria Rojas, Lucas Yáñez, Antonio Hidalgo, Marcela Olivera, Martín Pacheco, Darna Venegas, Daniela Salinas, Denisse Bravo, Andrew F.G. Quest   +9 more
doaj   +1 more source

Periodontal microbiology and microbial etiology of periodontal diseases: Historical concepts and contemporary perspectives

Periodontology 2000, EarlyView., 2023
Abstract This narrative review summarizes the collective knowledge on periodontal microbiology, through a historical timeline that highlights the European contribution in the global field. The etiological concepts on periodontal disease culminate to the ecological plaque hypothesis and its dysbiosis‐centered interpretation.
Georgios N. Belibasakis, Daniel Belstrøm, Sigrun Eick, Ulvi K. Gursoy, Anders Johansson, Eija Könönen   +5 more
wiley   +1 more source