Results 21 to 30 of about 2,402 (156)

Maturation of fimbria precursor protein by exogenous gingipains inPorphyromonas gingivalisgingipain-null mutant [PDF]

FEMS Microbiology Letters, 2007
Porphyromonas gingivalis expresses several virulence factors such as fimbriae and proteases, termed gingipains, which are enzymes that process precursor fimbriae proteins. Thus, gingipain-null mutants lack mature fimbriae. Membrane vesicle-depleted supernatants (VDS) containing soluble gingipains were prepared as an exogenous gingipain fraction ...
Takahiro, Kato, Tetsuhisa, Tsuda, Hiroko, Omori, Takafumi, Kato, Tamotsu, Yoshimori, Atsuo, Amano   +5 more
openaire   +2 more sources

Dual Inhibitory Activity of Petroselinic Acid Enriched in Fennel Against Porphyromonas gingivalis

Frontiers in Microbiology, 2022
Increasing evidence has shown that a major periodontal pathobiont, Porphyromonas gingivalis, triggers oral dysbiosis leading to deterioration not only of periodontal health, but also of several systemic conditions.
Nanami Yoshino, Nanami Yoshino, Tsuyoshi Ikeda, Ryoma Nakao   +3 more
doaj   +1 more source

Periodontitis and atherosclerotic cardiovascular disease: A critical appraisal

Periodontology 2000, EarlyView., 2023
Abstract In spite of intensive research efforts driving spectacular advances in terms of prevention and treatments, cardiovascular diseases (CVDs) remain a leading health burden, accounting for 32% of all deaths (World Health Organization. “Cardiovascular Diseases (CVDs).” WHO, February 1, 2017, https://www.who.int/news‐room/fact‐sheets/detail ...
Maria Clotilde Carra, Hélène Rangé, Giuseppina Caligiuri, Philippe Bouchard   +3 more
wiley   +1 more source

Lipoprotein modifications by gingipains of Porphyromonas gingivalis [PDF]

Journal of Periodontal Research, 2018
AbstractBackground and ObjectiveSeveral studies have shown an association between periodontitis and cardiovascular disease (CVD). Atherosclerosis is the major cause of CVD, and a key event in the development of atherosclerosis is accumulation of lipoproteins within the arterial wall.
J. Lönn, S. Ljunggren, K. Klarström‐Engström, I. Demirel, T. Bengtsson, H. Karlsson   +5 more
openaire   +5 more sources

Porphyromonas gingivalis gingipains potentially affect MUC5AC gene expression and protein levels in respiratory epithelial cells

FEBS Open Bio, 2021
Porphyromonas gingivalis (Pg) is a periodontopathic pathogen that may affect MUC5AC‐related mucus hypersecretion along airway epithelial cells. Here, we attempted to establish whether Pg virulence factors (lipopolysaccharide, FimA fimbriae, gingipains ...
Chihiro Miya, Marni E. Cueno, Ryuta Suzuki, Shuichiro Maruoka, Yasuhiro Gon, Tadayoshi Kaneko, Yoshiyuki Yonehara, Kenichi Imai   +7 more
doaj   +1 more source

Production and properties of adhesin-free gingipain proteinase RgpA

Scientific Reports, 2023
AbstractThe Arg-specific gingipains of Porphyromonas gingivalis RgpA and RgpB have 97% identical sequences in their catalytic domains yet their propeptides are only 76% identical. RgpA isolates as a proteinase–adhesin complex (HRgpA) which hinders direct kinetic comparison of RgpAcat as a monomer with monomeric RgpB.
Mahmud, ASM, Seers, CA, Huq, NL, Zhang, L, Butler, CA, Moore, C, Cross, KJ, Reynolds, EC   +7 more
openaire   +4 more sources

Sequential Autolytic Processing Activates the Zymogen of Arg-gingipain [PDF]

Journal of Biological Chemistry, 2003
Most proteases are synthesized as inactive precursors to protect the synthetic machinery of the cell and allow timing of activation. The mechanisms used to render latency are varied but tend to be conserved within protease families. Proteases belonging to the caspase family have a unique mechanism mediated by transitions of two surface loops, and on ...
Mikolajczyk, Jowita, Boatright, Kelly M., Stennicke, Henning R., Nazif, Tamim, Potempa, Jan, Bogyo, Matthew, Salvesen, Guy S.   +6 more
openaire   +3 more sources

Detection of gingipain activity using solid state nanopore sensors

Sensors and Actuators B: Chemical, 2022
Accurate, robust, and rapid diagnostics is the basis for all well-functioning healthcare. There is a large need in point-of-care biosensors to facilitate diagnosis and reduce the need for cumbersome laboratory equipment. Proteases are key virulence factors in periodontitis.
Palomar, Quentin, Svärd, Anna, Zeng, Shuangshuang, Hu, Qitao, Liu, Funing, Aili, Daniel, Zhang, Zhen   +6 more
openaire   +3 more sources

Protein Interactome Analysis of the Type IX Secretion System Identifies PorW as the Missing Link between the PorK/N Ring Complex and the Sov Translocon

Microbiology Spectrum, 2022
The type IX secretion system (T9SS) transports cargo proteins through the outer membrane of Bacteroidetes and attaches them to the cell surface for functions including pathogenesis, gliding motility, and degradation of carbon sources.
Dhana G. Gorasia, Ignacio Lunar Silva, Catherine A. Butler, Maïalène Chabalier, Thierry Doan, Eric Cascales, Paul D. Veith, Eric C. Reynolds   +7 more
doaj   +1 more source

Porphyromonas gingivalis Gingipains and Adhesion to Epithelial Cells [PDF]

Infection and Immunity, 2001
ABSTRACT Porphyromonas gingivalis is one of the principal organisms associated with adult periodontitis. Bacterial surface proteins such as fimbriae and gingipain hemagglutinin domains have been implicated as adhesins that actuate colonization of epithelium lining the gingival sulcus. We investigated the genetics of
T, Chen, K, Nakayama, L, Belliveau, M J, Duncan   +3 more
openaire   +2 more sources