Results 31 to 40 of about 2,402 (156)

Porphyromonas gingivalis induces penetration of lipopolysaccharide and peptidoglycan through the gingival epithelium via degradation of junctional adhesion molecule 1.

PLoS Pathogens, 2019
Porphyromonas gingivalis is a major pathogen in severe and chronic manifestations of periodontal disease, which is one of the most common infections of humans. A central feature of P.
Hiroki Takeuchi, Naoko Sasaki, Shunsuke Yamaga, Masae Kuboniwa, Michiya Matsusaki, Atsuo Amano   +5 more
doaj   +1 more source

Gingipains as the determinants of periodontopathogenicity

Folia Pharmacologica Japonica, 2003
The arginine-specific cysteine proteinase (Arg-gingipain, Rgp) and lysine-specific cysteine proteinase (Lys-gingipain, Kgp) are produced by Porphyromonas gingivalis, an etiological bacterium of periodontal disease. Rgp and Kgp have been implicated as the major virulent factors because of their degrading activity to a broad range of host proteins and of
Tomoko, Kadowaki, Ryosuke, Takii, Atsuyo, Baba, Kenji, Yamamoto   +3 more
openaire   +3 more sources

Porphyromonas gingivalis laboratory strains and clinical isolates exhibit different distribution of cell surface and secreted gingipains

Journal of Oral Microbiology, 2021
Background: The cell-surface cysteine proteinases RgpA, RgpB (Arg-gingipain), and Kgp (Lys-gingipain) are major virulence factors of P. gingivalis, a keystone pathogen in the development of destructive periodontal disease.
Christine A. Seers, A. Sayeed M. Mahmud, N. Laila Huq, Keith J. Cross, Eric C. Reynolds   +4 more
doaj   +1 more source

Dysregulation of Stress-Induced Translational Control by Porphyromonas gingivalis in Host Cells

Microorganisms, 2023
Porphyromonas gingivalis contributes to the chronic oral disease periodontitis, triggering the activation of host inflammatory responses, inducing cellular stresses such as oxidation. During stress, host cells can activate the Integrated Stress Response (
Alex A. Knowles, Susan G. Campbell, Neil A. Cross, Prachi Stafford   +3 more
doaj   +1 more source

Inactive Gingipains from P. gingivalis Selectively Skews T Cells toward a Th17 Phenotype in an IL-6 Dependent Manner

Frontiers in Cellular and Infection Microbiology, 2017
Gingipain cysteine proteases are considered key virulence factors of Porphyromonas gingivalis. They significantly influence antibacterial and homeostatic functions of macrophages, neutrophils, the complement system, and cytokine networks.
Jan Potempa, Jan Potempa, Joanna Koziel, Izabela Glowczyk, Alicia Wong, Barbara Potempa, Olena Babyak, Maciej Lech, Maciej Lech, Richard J. Lamont   +9 more
doaj   +1 more source

Iron Dysregulation and Inflammagens Related to Oral and Gut Health Are Central to the Development of Parkinson’s Disease

Biomolecules, 2020
Neuronal lesions in Parkinson’s disease (PD) are commonly associated with α-synuclein (α-Syn)-induced cell damage that are present both in the central and peripheral nervous systems of patients, with the enteric nervous system also being especially ...
Marthinus Janse van Vuuren, Theodore Albertus Nell, Jonathan Ambrose Carr, Douglas B. Kell, Etheresia Pretorius   +4 more
doaj   +1 more source

Research progress on the pathogenicity of Porphyromonas gingivalis clinical strains

口腔疾病防治, 2023
Porphyromonas gingivalis (P. gingivalis) is closely related to the occurrence and development of periodontitis. It is considered to be one of the important pathogens leading to alveolar bone resorption. At present, research on P. gingivalis mostly adopts
WU Yajie , LI Yuqing, ZHOU Fangjie, LI Jiyao   +3 more
doaj   +1 more source

The impact of virulence factors of Porphyromonas gingivalis on wound healing in vitro

Journal of Oral Microbiology, 2015
Background: Porphyromonas gingivalis inhibits oral epithelial wound healing in vitro more strongly than other oral bacteria, but it is unknown why P. gingivalis is such a potent inhibitor of wound healing.
Alexa M. G. A. Laheij, Cor van Loveren, Dongmei Deng, Johannes J. de Soet   +3 more
doaj   +1 more source

Outer membrane vesicles of the oral pathogen Porphyromonas gingivalis promote aggregation and phagocytosis of Staphylococcus aureus

Frontiers in Oral Health, 2022
Staphylococcus aureus is an opportunistic Gram-positive bacterial pathogen that causes a wide variety of infectious diseases, including S. aureus bacteremia (SAB).
Marines du Teil Espina, Anna Haider Rubio, Yanyan Fu, Marina López-Álvarez, Giorgio Gabarrini, Jan Maarten van Dijl   +5 more
doaj   +1 more source

Porphyromonas gingivalis suppresses invasion of Fusobacterium nucleatum into gingival epithelial cells

Journal of Oral Microbiology, 2017
Invasion of periodontal pathogens into periodontal tissues is an important step that can cause tissue destruction in periodontal diseases. Porphyromonas gingivalis is a keystone pathogen and its gingipains are key virulence factors.
Young-Jung Jung, Hye-Kyoung Jun, Bong-Kyu Choi   +2 more
doaj   +1 more source