Results 41 to 50 of about 2,402 (156)

Propeptide-Mediated Inhibition of Cognate Gingipain Proteinases

PLoS ONE, 2013
Porphyromonas gingivalis is a major pathogen associated with chronic periodontitis. The organism's cell-surface cysteine proteinases, the Arg-specific proteinases (RgpA, RgpB) and the Lys-specific proteinase (Kgp), which are known as gingipains have been implicated as major virulence factors.
Huq, N. Laila, Seers, Christine A., Toh, Elena C. Y., Dashper, Stuart G., Slakeski, Nada, Zhang, Lianyi, Ward, Brent R., Meuric, Vincent, Chen, Dina, Cross, Keith J., Reynolds, Eric C   +10 more
openaire   +6 more sources

Unrevealing the Proteolytic Activity of RgpB Gingipain from Computational Simulations

Journal of Chemical Information and Modeling, 2021
Alzheimer's disease represents one of the greatest medical concerns for today's population and health services. Its multifactorial inherent nature represents a challenge for its treatment and requires the development of a broad spectrum of drugs. Recently, the cysteine protease gingipain RgpB has been related to neurodegenerative diseases, including ...
Santiago Movilla, Sergio Martí, Maite Roca, Vicent Moliner   +3 more
openaire   +3 more sources

Functional characteristics of antibodies induced by Arg‐gingipain (HRgpA) and Lys‐gingipain (Kgp) from Porphyromonas gingivalis

Oral Microbiology and Immunology, 2001
Arginine‐specific gingipain (HRgpA) and lysine‐specific gingipain (Kgp), enzymes produced by Porphyromonas gingivalis, may be candidates for an anti–P. gingivalis vaccine. The purpose of our study was to determine whether HRgpA and Kgp have opsonic target sites and whether these sites are available and accessible on intact P. gingivalis cells.
Nakagawa, T., Sims, T., Fan, Q., Potempa, Jan, Travis, J., Houston, L., Page, R. C.   +6 more
openaire   +3 more sources

Triggering NETosis via protease-activated receptor (PAR)-2 signaling as a mechanism of hijacking neutrophils function for pathogen benefits.

PLoS Pathogens, 2019
Neutrophil-derived networks of DNA-composed extracellular fibers covered with antimicrobial molecules, referred to as neutrophil extracellular traps (NETs), are recognized as a physiological microbicidal mechanism of innate immunity.
Danuta Bryzek, Izabela Ciaston, Ewelina Dobosz, Anna Gasiorek, Anna Makarska, Michal Sarna, Sigrun Eick, Magdalena Puklo, Maciej Lech, Barbara Potempa, Jan Potempa, Joanna Koziel   +11 more
doaj   +1 more source

Characterization of Human Genes Modulated by Porphyromonas gingivalis Highlights the Ribosome, Hypothalamus, and Cholinergic Neurons

Frontiers in Immunology, 2021
Porphyromonas gingivalis, a bacterium associated with periodontal disease, is a suspected cause of Alzheimer’s disease. This bacterium is reliant on gingipain proteases, which cleave host proteins after arginine and lysine residues.
Sejal Patel, Derek Howard, Nityananda Chowdhury, Casey Derieux, Bridgette Wellslager, Özlem Yilmaz, Özlem Yilmaz, Leon French, Leon French, Leon French, Leon French   +10 more
doaj   +1 more source

Porphyromonas gingivalis Gingipains Destroy the Vascular Barrier and Reduce CD99 and CD99L2 Expression To Regulate Transendothelial Migration

Microbiology Spectrum, 2023
Porphyromonas gingivalis is an important periodontal pathogen that can cause vascular injury and invade local tissues through the blood circulation, and its ability to evade leukocyte killing is critical to its distal colonization and survival ...
Zhaolei Zou, Juan Fang, Wanting Ma, Junyi Guo, Zhongyan Shan, Da Ma, Qiannan Hu, Liling Wen, Zhi Wang   +8 more
doaj   +1 more source

Gingipains as candidate antigens for Porphyromonas gingivalis vaccine

The Keio Journal of Medicine, 2003
Porphyromonas gingivalis (P. gingivalis), a gram-negative anaerobe, is involved in the pathogenesis of periodontal disease, and is found frequently in the subgingival flora in patients with periodontitis. This organism possesses a variety of virulence factors including lipopolysaccharide, capsular material, fimbriae and proteases (enzymes). Among the P.
Taneaki, Nakagawa, Atsushi, Saito, Yasuo, Hosaka, Kazuyuki, Ishihara   +3 more
openaire   +3 more sources

Porphyromonas gingivalis Infection Induces Lipopolysaccharide and Peptidoglycan Penetration Through Gingival Epithelium

Frontiers in Oral Health, 2022
Periodontal diseases initiate on epithelial surfaces of the subgingival compartment, while the gingival epithelium functions as an epithelial barrier against microbial infection and orchestrates immune responses.
Hiroki Takeuchi, Eriko Nakamura, Shunsuke Yamaga, Atsuo Amano   +3 more
doaj   +1 more source

Taurolidine Acts on Bacterial Virulence Factors and Does Not Induce Resistance in Periodontitis-Associated Bacteria—An In-Vitro Study

Antibiotics, 2020
The aims of the present study were: (a) to determine the mechanism of action of taurolidine against bacterial species associated with periodontal disease, and (b) to evaluate the potential development of resistance against taurolidine as compared with ...
Sabrina Radakovic, Nicola Andreoli, Simon Schmid, Sandor Nietzsche, Jürg Zumbrunn, Anton Sculean, Sigrun Eick   +6 more
doaj   +1 more source

Role of Acetyltransferase PG1842 in Gingipain Biogenesis in Porphyromonas gingivalis [PDF]

Journal of Bacteriology, 2018
Gingipain proteases are key virulence factors secreted by Porphyromonas gingivalis that cause periodontal tissue damage and the degradation of the host immune system proteins. Gingipains are translated as an inactive zymogen to restrict intracellular proteolytic activity before secretion.
Arunima, Mishra, Francis, Roy, Yuetan, Dou, Kangling, Zhang, Hui, Tang, Hansel M, Fletcher   +5 more
openaire   +2 more sources