Results 51 to 60 of about 2,402 (156)

Ultrastructural localization of Porphyromonas gingivalis gingipains in the substantia nigra of Parkinson’s disease brains

npj Parkinson's Disease
Gingipains are protease virulence factors produced by Porphyromonas gingivalis, a Gram-negative bacterium best known for its role in chronic periodontitis. Gingipains were recently identified in the middle temporal gyrus of postmortem Alzheimer’s disease
Florian Ermini, Victoria F. Low, Jennifer J. Song, Adelie Y. S. Tan, Richard L. M. Faull, Michael Dragunow, Maurice A. Curtis, Stephen S. Dominy   +7 more
doaj   +1 more source

Salivary microbiota and clinical periodontal measures predicting cardiometabolic disease mortality: A nationwide survey

Journal of Periodontology, EarlyView.
Abstract Background Although periodontitis and oral microbiota are linked to cardiometabolic diseases (CMD), it is unclear if they similarly predict CMD mortality. We compared the predictive ability of salivary microbiota and periodontal disease measures for CMD mortality in the National Health and Nutrition Examination Survey (NHANES).
Hamdi S. Adam, Weihua Guan, Abigail J. Johnson, Sanaz Sedaghat, Charlene Goh, James S. Pankow, Ryan T. Demmer   +6 more
wiley   +1 more source

The association of periodontal inflammation and inflammatory markers with cognitive dysfunction: A case–control study

Journal of Periodontology, EarlyView.
Abstract Background This study investigated the association of inflammatory markers in saliva, plasma, and cerebrospinal fluid (CSF) with cognitive decline and periodontitis. Methods Patients with Alzheimer disease (AD, n = 52), mild cognitive impairment (MCI, n = 51), subjective cognitive decline (SCD, n = 51), and controls (n = 76) between 50 and 80 ...
Kåre Buhlin, Maria Eriksdotter, Leif Jansson, Pirkko J. Pussinen, Marianne Schultzberg, Ronaldo Lira‐Junior   +5 more
wiley   +1 more source

Hydrolysis of Epithelial Junctional Proteins byPorphyromonas gingivalisGingipains [PDF]

Infection and Immunity, 2002
ABSTRACTPorphyromonas gingivalishas been implicated as an etiologic agent of adult periodontitis. We have previously shown thatP. gingivaliscan degrade the epithelial cell-cell junction complexes, thus suggesting that this bacterium can invade the underlying connective tissues via a paracellular pathway.
Jannet, Katz, Qiu-Bo, Yang, Ping, Zhang, Jan, Potempa, James, Travis, Suzanne M, Michalek, Daniel F, Balkovetz   +6 more
openaire   +2 more sources

Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases

Journal of Oral Microbiology, 2014
Gingipains are the major virulence factors of Porphyromonas gingivalis, the main periodontopathogen. It is expected that inhibition of gingipain activity in vivo could prevent or slow down the progression of adult periodontitis.
Ingar Olsen, Jan Potempa
doaj   +1 more source

Alternative Polyadenylation Drives Runaway Pro‐Inflammatory Macrophages in Periodontitis by Enabling Escape From miRNA Repression

Cell Proliferation, EarlyView.
APA‐Guided Therapeutic miRNA Selection for Periodontitis. ABSTRACT Periodontitis is a chronic inflammatory disease driven by a dysregulated host immune response, in which macrophage‐mediated inflammation shifts from protective to pathological. While monocyte‐derived macrophages (MDMs) are known to adopt a destructive, M1‐like pro‐inflammatory phenotype,
Jing Zhang, Yilong Zhao, Jiaru Deng, Shuyuan Qu, Yiyi Zhou, Qin Zhao, Yufeng Zhang   +6 more
wiley   +1 more source

Role of Porphyromonas gingivalis gingipains in multi-species biofilm formation [PDF]

BMC Microbiology, 2014
Periodontal diseases are polymicrobial diseases that cause the inflammatory destruction of the tooth-supporting (periodontal) tissues. Their initiation is attributed to the formation of subgingival biofilms that stimulate a cascade of chronic inflammatory reactions by the affected tissue. The Gram-negative anaerobes Porphyromonas gingivalis, Tannerella
Bao, K, Belibasakis, GN, Thurnheer, T, Aduse-Opoku, J, Curtis, MA, Bostanci, N   +5 more
openaire   +4 more sources

Parkinson’s Disease: A Systemic Inflammatory Disease Accompanied by Bacterial Inflammagens

Frontiers in Aging Neuroscience, 2019
Parkinson’s disease (PD) is a well-known neurodegenerative disease with a strong association established with systemic inflammation. Recently, the role of the gingipain protease group from Porphyromonas gingivalis was implicated in Alzheimer’s disease ...
Büin Adams, J. Massimo Nunes, Martin J. Page, Timothy Roberts, Timothy Roberts, Jonathan Carr, Theo A. Nell, Douglas B. Kell, Douglas B. Kell, Etheresia Pretorius   +9 more
doaj   +1 more source

Porphyromonas gingivalis and Treponema denticola synergistic polymicrobial biofilm development. [PDF]

PLoS ONE, 2013
Chronic periodontitis has a polymicrobial biofilm aetiology and interactions between key bacterial species are strongly implicated as contributing to disease progression.
Ying Zhu, Stuart G Dashper, Yu-Yen Chen, Simon Crawford, Nada Slakeski, Eric C Reynolds   +5 more
doaj   +1 more source

Dysbiosis‐Mediated Inflammation: A Pathophysiological Link Between Rheumatoid Arthritis and Periodontitis

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To explore mechanistic links between rheumatoid arthritis (RA) and periodontitis (PD) through the lens of subgingival microbial dysbiosis–mediated inflammation. Methods Subgingival plaque from 100 volunteers with RA and PD (RAPD), 22 with RA (RAnoPD), 18 with PD (PDnoRA) and 19 healthy controls (noRAnoPD) was analysed using 16S‐amplicon ...
Isabel Lopez‐Oliva, Iain L. Chapple, Akshay Paropkari, Shweta Saraswat, Praveen Sharma, Stefan Serban, Paola de Pablo, Karim Raza, Andrew Filer, Thomas Dietrich, Melissa Grant, Purnima S. Kumar   +11 more
wiley   +1 more source