Results 91 to 100 of about 2,581 (218)

Multi-targeting aurones with monoamine oxidase and amyloid-beta inhibitory activities: structure-activity relationship and translating multi-potency to neuroprotection [PDF]

, 2019
Previously, a series of aurones bearing amine and carbamate functionalities was synthesized and evaluated for their cholinesterase inhibitory activity and drug-like attributes.
Chan, Kit Lam, Lee, Chong Yew, Lee, Elaine Hui-Chien, Liew, Kok-Fui   +3 more
core   +1 more source

Advanced Synthetic Strategies toward Ginkgolide Diterpenoids: Total Synthesis of (±)-Ginkgolide C and Formal Syntheses of (±)-Ginkgolides A and B

The Journal of Organic Chemistry
Ginkgolides are highly oxygenated diterpenes isolated from Ginkgo biloba that exhibit potent anti-inflammatory and neuroprotective properties. Their compact hexacyclic architecture─featuring multiple contiguous stereocenters, a spirocyclic core, and a rare tert-butyl group─presents a formidable challenge in synthetic organic chemistry.
Louis Barriault, Martin Hébert, Gabriel Bellavance   +2 more
openaire   +2 more sources

Pharmacological action and mechanisms of ginkgolide B

Chinese Medical Journal, 2007
To review the recent research progress in pharmacological actions and mechanisms of ginkgolide B. Data sources Information included in this article was identified by searching of PUBMED (1987 - 2006) online resources using the key terms "ginkgolide B", "platelet activating factor", and "pharmacological".
Shi-hai, Xia, Dian-chun, Fang
openaire   +2 more sources

An Up‐to‐Date Review of Traditional Chinese Medicine in the Treatment of Atherosclerosis: Components, Mechanisms, and Therapeutic Potentials

Phytotherapy Research, Volume 39, Issue 8, Page 3709-3735, August 2025.
Traditional Chinese medicine in atherosclerosis: multi‐target modulation of pathogenesis. ABSTRACT Atherosclerosis is a chronic inflammatory disease and a major global health concern. In recent years, traditional Chinese medicines (TCMs) have demonstrated multi‐target therapeutic potential against atherosclerosis by modulating inflammatory responses ...
Dilaram Nijat, Qingzhe Zhao, Gulhasal Abdurixit, Jianhua He, Haipeng Liu, Jinyao Li   +5 more
wiley   +1 more source

Effect of Levopimaradiene on Terpene Trilactones Biosynthesis and Gene Expression Profiling in Cells

Natural Product Communications, 2017
Ginkgolides (GKs) and Bilobalide (BB) are rare terpene trilactones obtained from Ginkgo biloba , but their biosynthetic pathway is still unclear. In this paper, effects of levopimaradiene (LP) on increasing the production of terpene trilactones of G ...
Jianhua Zhu, Pu Wang, Minghua Qian, Chuxin Liang, Jiachen Zi, Rongmin Yu   +5 more
doaj   +1 more source

Plant Polyphenols in Obesity and Obesity-Associated Metabolic Disorders: A Narrative Review of Resveratrol and Flavonoids Upon the Molecular Basis of Inflammation [PDF]

, 2018
Background: The epidemic of obesity, metabolic syndrome, type 2 diabetes and non-alcoholic fatty liver disease is currently unsustainable for Public Health systems, and preventive and therapeutic approaches are urgently sought to improve health outcomes ...
Bueno, Allain, de Jesus, R.P., González-Muniesa, P., Mota, J.F., Telles, M.M., Waitzberg, D.L.   +5 more
core   +1 more source

Levodopa and Plant‐Derived Bioactive Compounds in Parkinson's Disease: Mechanisms, Efficacy, and Future Perspectives

CNS Neuroscience &Therapeutics, Volume 31, Issue 8, August 2025.
Plant‐derived compounds such as polyphenols, flavonoids, alkaloids, and terpenoids exhibit neuroprotective, antioxidant, and anti‐inflammatory activities in Parkinson's disease models. Unlike levodopa, they provide disease‐modifying benefits by targeting α‐synuclein aggregation, mitochondrial dysfunction, and neuroinflammation.
Emre Aktaş, Haşmet Ayhan Hanağası, Nehir Özdemir Özgentürk   +2 more
wiley   +1 more source

Molecular Cloning, Characterization, and Functional Analysis of Acetyl-CoA C-Acetyltransferase and Mevalonate Kinase Genes Involved in Terpene Trilactone Biosynthesis from Ginkgo biloba

Molecules, 2017
Ginkgolides and bilobalide, collectively termed terpene trilactones (TTLs), are terpenoids that form the main active substance of Ginkgo biloba. Terpenoids in the mevalonate (MVA) biosynthetic pathway include acetyl-CoA C-acetyltransferase (AACT) and ...
Qiangwen Chen, Jiaping Yan, Xiangxiang Meng, Feng Xu, Weiwei Zhang, Yongling Liao, Jinwang Qu   +6 more
doaj   +1 more source

Efficiency of integrated plant adaptogen for optimizing mental capacity in older school age children [PDF]

, 2016
Збільшення навантаження шкільних програм, формуван-ня тривалого «шкільного стресу» призводять до порушень процесів пам’яті, уваги у школярів, що потребує періодичного застосування не лише запобіжних (профілактичних), а й відновлювальних (ліку-вальних ...
Камінська, Т.М., Муквіч, О.М., Пінчук, Л.П.   +2 more
core  

Potential benefits of phytochemicals against Alzheimer's disease [PDF]

, 2017
Our current therapeutic drugs for Alzheimer's disease are predominantly derived from the alkaloid class of plant phytochemicals. These drugs, such as galantamine and rivastigmine, attenuate the decline in the cholinergic system but, as the alkaloids ...
Wightman, Emma
core   +1 more source