Results 91 to 100 of about 1,719 (204)

Diterpene Ginkgolides Exert an Antidepressant Effect Through the NT3-TrkA and Ras-MAPK Pathways

Drug Design, Development and Therapy, 2020
Ting Wang,1– 3,* Shunjie Bai,1– 3,* Wei Wang,2– 4,* Zhi Chen,2,3 Jianjun Chen,2,3 Zihong Liang,5 Xunzhong Qi,2– 4 Hailan Shen,1 Peng Xie1– 6 1Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing ...
Wang T, Bai S, Wang W, Chen Z, Chen J, Liang Z, Qi X, Shen H, Xie P   +8 more
doaj  

Advanced Synthetic Strategies toward Ginkgolide Diterpenoids: Total Synthesis of (±)-Ginkgolide C and Formal Syntheses of (±)-Ginkgolides A and B

The Journal of Organic Chemistry
Ginkgolides are highly oxygenated diterpenes isolated from Ginkgo biloba that exhibit potent anti-inflammatory and neuroprotective properties. Their compact hexacyclic architecture—featuring multiple contiguous stereocenters, a spirocyclic core, and a rare tert-butyl group—presents a formidable challenge in synthetic organic chemistry.
Louis Barriault, Martin Hébert, Gabriel Bellavance   +2 more
openaire   +2 more sources

Ginkgolides and Neuroprotective Effects

, 2013
Syed Haris Omar
openaire   +2 more sources

Pharmacological action and mechanisms of ginkgolide B

Chinese Medical Journal, 2007
To review the recent research progress in pharmacological actions and mechanisms of ginkgolide B. Data sources Information included in this article was identified by searching of PUBMED (1987 - 2006) online resources using the key terms "ginkgolide B", "platelet activating factor", and "pharmacological".
Shi-hai, Xia, Dian-chun, Fang
openaire   +2 more sources

Effect of biotic elicitors on the accumulation of bilobalide and ginkgolides in Ginkgo biloba cell cultures

, 2009
The effect of biotic elicitors on the production of bilobalide and ginkgolides in Ginkgo biloba cell suspension cultures was studied. The treatment of cell cultures with Candida albicans and Staphylococcus aureus as elicitors increased the amounts of ...
Kim, Y.-D., Karigar, C.S., Min, J.-Y., Kang, S.-M., Goo, G.-H., Kim, S.-W., Choi, M.-S.   +6 more
core   +1 more source

4'-O-Methylpyridoxine and ginkgolides as biological markers of Ginkgo biloba poisoning

, 2016
Ginkgo biloba belongs to the family of Ginkgoaceae. According to the traditional medicine, leaf extracts are used for the improvement of blood circulation and the enhancement of memory and concentration, while in some Asian countries, Ginkgo biloba seeds
A. Ceschi, M. von Dechend, F. Colombo, S. Lude, E. Valori, C. Di Lorenzo, G. Frigerio, P. Restani, M. G. Bianchetti   +8 more
core   +2 more sources

Effects of Taurine and Ginkgo biloba Extract on Platelet Aggregation [PDF]

, 2002
Effects of the leaf extract Ginkgo biloba, ginkgolides A and B, and the amino acid taurine (2-aminoethane sulfonic acid) on platelet aggregation was studied.
Miglis, Mitchell G
core   +1 more source

Insight into the metabolic mechanism of Diterpene Ginkgolides on antidepressant effects for attenuating behavioural deficits compared with venlafaxine

, 2017
Depression is a severe and chronic mental disorder, affecting about 322 million individuals worldwide. A recent study showed that diterpene ginkgolides (DG) have antidepressant-like effects on baseline behaviours in mice. Here, we examined the effects of
Peng Xie, Peng Shen, Xiongfei Xie, Shunjie Bai, Qingchuan Hu, Jianjun Chen, Hua Huang, Zihong Liang, Siwen Gui, Yu Han, Zhi Chen, Li Zeng, Haiyang Wang, Zhao Liu, Xiaodong Zhang, Wei Wang   +15 more
core   +1 more source

Structure-activity analysis of ginkgolide binding in the glycine receptor pore

, 2008
Ginkgolides, active constituents of Ginkgo biloba extracts, potently block the glycine receptor chloride channel (GlyR). Ginkgolides A, B, C and J are structurally similar, varying only by the presence or absence of oxygens at their R1 and R2 positions ...
Rebecca L. Hawthorne, Hawthorne, Rebecca L., Lynch, J. W., Lynch, Joseph W., Timothy Lynagh, Hawthorne, R. L., Judith A. Heads, Lynagh, Timothy, Lynagh, T., Heads, Judith A., Joseph W. Lynch, Heads, J. A.   +11 more
core   +1 more source

Isolation and identification of ginkolides-producing endophytic fungi from Ginkgo biloba Linn.

, 2017
In the present study, the method of tissue culturing was used to isolate the endophytic fungi from healthy ginkgo roots and stems. After repeated separation and purification, 116 Ginkgo endophytes were isolated.
Xiaoming, CHEN, Fulin, HE, Zhizhong, LI, Zhihui, YUAN   +3 more
core   +1 more source