Results 81 to 90 of about 2,581 (218)

Pharmacokinetics of Ginkgolide B after Oral Administration of Three Different Ginkgolide B Formulations in Beagle Dogs [PDF]

Molecules, 2015
Ginkgolide B (GB), an important active constituent of Ginkgo biloba extract, has been used in clinical applications for the treatment of dementia, cerebral insufficiency or related cognitive decline. To investigate the main pharmacokinetic characteristics of three different GB formulations in beagle dogs, a simple, specific and sensitive LC-MS/MS ...
Jie Zhao, Ting Geng, Qi Wang, Haihong Si, Xiaoping Sun, Qingming Guo, Yanjing Li, Wenzhe Huang, Gang Ding, Wei Xiao   +9 more
openaire   +3 more sources

Modulation of Aging Diseases via RAGE Targets: A Dietary Intervention Review

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This paper analyzes RAGE ligand‐binding mechanisms and signaling, proposing intervention strategies targeting these interactions. It emphasizes dietary polyphenols, polysaccharides, and terpenoids delivered via functional foods for anti‐aging. These compounds offer long‐term, safe intervention through dietary supplementation, providing dual nutritional
Qian Wu, Jia Yan, Yuyan Zhang, Xiaozhi Ming, Siqi Chen, Zhichao Zou, Nianjie Feng, Jianbo Xiao   +7 more
wiley   +1 more source

Enhanced transport of plant-produced rabies single chain antibody-RVG peptide fusion protein across an in cellulo blood-brain barrier device [PDF]

, 2017
The biomedical applications of antibody engineering are developing rapidly and have been expanded to plant expression platforms. In this study, we have generated a novel antibody molecule in planta for targeted delivery across the blood–brain barrier ...
Al-Shehri, Alyautdin, Alyautdin, Bird, Boado, Both, Bracci, Burrage, Chopy, Donnelly-Roberts, Eigenmann, Fooks, Friden, Fu, Greene, Gulyaev, Hefferon, Helm, Hemachudha, Hwang do, Jekic, Kim, Kohli, Kumar, Kwon, Lentz, Lentz, Lentz, Lentz, Lentz, Lentz, Lewis, Lim, Liu, Louie, Ma, Markoutsa, McQuarrie, Megret, Muller, Pardridge, Pardridge, Pardridge, Peyret, Rosales-Mendoza, Roy, Rustici, Sainsbury, Schwarze, Shahid, Shantavasinkul, Siflinger-Birnboim, Thoulouze, Tzartos, Uwanyiligira, Xiang, Yamauchi   +56 more
core   +1 more source

Systematic Review Suggests Nutraceuticals Containing Vitamin B2 Could Provide an Alternative Treatment for Paediatric Migraines

Acta Paediatrica, Volume 114, Issue 10, Page 2443-2457, October 2025.
ABSTRACT Aim The aim of this review is to systematically summarise the evidence on the effectiveness of riboflavin (vitamin B2) or supplements containing riboflavin in preventing paediatric migraines. Methods This systematic review followed the Joanna Briggs Institute methodology and is reported to adhere to the Preferred Reporting Items for Systematic
Elisa Martello, Fatimah Aiyelabegan, Jemma Orr, Emma Wilson, Joanne R. Morling, Maria Kinali, Titus Joseph, Dirontsho Koboto, Surakshya Dhungana, Prudence Ikechukwu, Princella Seripenah, Heidi Emery, James Stewart‐Evans, Jo Leonardi‐Bee   +13 more
wiley   +1 more source

Glycine receptors in CNS neurons as a target for nonretrograde action of cannabinoids [PDF]

, 2005
At many central synapses, endocannabinoids released by postsynaptic cells act retrogradely on presynaptic G-protein-coupled cannabinoid receptors to inhibit neurotransmitter release.
Beketov, A., Burnashev, N., Lozovaya, N., Tsintsadze, T., Yatsenko, N.   +4 more
core   +2 more sources

Mitochondrial Ca2+ in Cancer Growth and Metabolism

Journal of Cellular Physiology, Volume 240, Issue 9, September 2025.
ABSTRACT Cancer is a leading cause of death in developed countries, despite many breakthroughs in targeted small molecule and immunotherapeutic interventions. A deeper understanding of the characteristics and processes that underlie malignancy will enable us to develop more effective therapeutic options to improve patient outcomes.
Jillian S. Weissenrieder, J. Kevin Foskett   +1 more
wiley   +1 more source

In Situ Assembly of Fluorogenic RNA for Screening Natural Anti‐Liver Fibrosis Products via Dynamic Visualization of COL1A1 mRNA

Advanced Science, Volume 12, Issue 30, August 14, 2025.
This study introduces an in situ assembly of fluorogenic RNA approach for screening natural anti‐liver fibrosis compounds and dynamic visualization of endogenous COL1A1 mRNA in live cells. It offers a simple, cost‐effective approach of visualizing RNA dynamics and conducting drug screening in live cells, presenting a significant potential for the ...
Rui Bai, Li‐Zeng Zhu, Changfa Shao, Zheng Yin, Qun Liu, Yu Gu, Bin Liu   +6 more
wiley   +1 more source

Diterpene Ginkgolides Exert an Antidepressant Effect Through the NT3-TrkA and Ras-MAPK Pathways

Drug Design, Development and Therapy, 2020
Ting Wang,1– 3,* Shunjie Bai,1– 3,* Wei Wang,2– 4,* Zhi Chen,2,3 Jianjun Chen,2,3 Zihong Liang,5 Xunzhong Qi,2– 4 Hailan Shen,1 Peng Xie1– 6 1Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing ...
Wang T, Bai S, Wang W, Chen Z, Chen J, Liang Z, Qi X, Shen H, Xie P   +8 more
doaj  

Electrocardiographic profile of guinea pig heart submitted to Ginkgo biloba extract and its terpenoids

Revista Brasileira de Plantas Medicinais, 2014
Electrocardiographic effects produced by Ginkgo biloba extract (EGb) and by ginkgolides A (GA) and B (GB), and bilobalide (BB) were investigated in guinea pig heart mounted in Langendorff apparatus (Tyrode, 34 ± 0.1 ºC, 95% O2, 5% CO2 ...
A.C.O. Santos, J.A.S. Souza, E.A. Conde-Garcia, A.A. Souza, J.E.R. Menezes-Filho, E.D. Oliveira, C.M.L Vasconcelos   +6 more
doaj   +1 more source

認知症予防のための食品・生薬・漢方薬 [PDF]

, 2020
認知症患者数の急増と高齢者医療費増が深刻な社会問題となっている。国は健康21（二次）を制定し、生活習慣病の予防を中心に掲げ医療費削減を目指している。また、最近認知症の発症を抑える数値目標が立てられた。認知症はアルツハイマー型認知症がほぼ50％でレビー小体型認知症と血管性認知症が続く。治療薬として進行を遅らせる薬が数種市販されているが、抜本的な治療薬や予防薬は上市されていない。このため疫学調査等で認知症予防に有効と認められた食品や生薬、また漢方薬等に頼らざるを得ない現状である ...
Yukihiro SHOYAMA, 正山 征洋
core   +1 more source