Shuangshen granules enhance anti-PD1 therapy effectiveness in lung adenocarcinoma by modulating myeloid-derived suppressor cell-induced T cell exhaustion. [PDF]
He ZN +16 more
europepmc +1 more source
Ginsenoside Rg3 potentiates cisplatin antitumor activity while mitigating nephrotoxicity through SIRT1‑mediated suppression of the NLRP3 inflammasome. [PDF]
Zhai J, Zhang Y, Gong J, Fu L, Zhang S.
europepmc +1 more source
Investigation of the immunoregulatory mechanisms of total saponins from black ginseng. [PDF]
Wang K +6 more
europepmc +1 more source
Ginsenoside Rg1 Improves PTSD-Like Sleep Disturbances in Male Mice: Involvement of NLRP3-Related Inflammatory and Apoptotic Pathways. [PDF]
Yang C +7 more
europepmc +1 more source
Panax quinquefolium saponin decreases atherosclerosis in ovariectomized ApoE<sup>-/-</sup> mice via regulating estrogen receptor α. [PDF]
Chen L +9 more
europepmc +1 more source
Effects of Minor Ginsenosides, Ginsenoside Metabolites, and Ginsenoside Epimers on the Growth of Caenorhabditis elegans [PDF]
In the previous report, we have demonstrated that ginsenoside Rc, one of major ginsenosides, is a major component for the restoration for normal growth of worms in cholesterol-deprived medium. In the present study, we further investigated the roles of minor ginsenosides, such as ginsenoside Rh1 and Rh2, ginsenoside metabolites such as compound K (CK ...
Joon-Hee Lee +2 more
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Conversion of Major Ginsenoside Rb1 to Ginsenoside F2 by Caulobacter leidyia
Biotechnology Letters, 2006Ginsenoside Rb1 is the most predominant ginsenoside in Panax species (ginseng) and the hydrolysis of this ginsenoside produces pharmaceutically active compounds. Caulobacter leidyia GP45, one of the isolates having strong beta-glucosidase-producing activity, converted ginsenoside Rb(1) to the active metabolites by 91%.
Myung Kyum Kim +2 more
exaly +3 more sources
Mitochondrial connection to ginsenosides
Archives of Pharmacal Research, 2020Mitochondria play an essential role in energy synthesis and supply, thereby maintaining cellular function, survival, and energy homeostasis via mitochondria-mediated pathways, including apoptosis and mitophagy. Ginsenosides are responsible for most immunological and pharmacological activities of ginseng, a highly beneficial herb with antioxidant, anti ...
Feng Wang, Yoon Seok Roh
openaire +2 more sources

