Ginsenoside Rb1 improves energy metabolism after spinal cord injury [PDF]
Neural Regeneration Research, 2023 Mitochondrial damage caused by oxidative stress and energy deficiency induced by focal ischemia and hypoxia are important factors that aggravate diseases. Studies have shown that ginsenoside Rb1 has neurotrophic and neuroprotective effects.
Shan Wen +6 more
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Pharmacological Mechanism and Drug Research Prospects of Ginsenoside Rb1 as an Antidepressant [PDF]
AntioxidantsThis review explores the antidepressant effects of ginsenoside Rb1, a natural compound in traditional Chinese medicine, and its potential for treating major depressive disorder (MDD).
Shuhui Zhuang +6 more
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Ginsenoside Rb1 affects mitochondrial Ca2+ transport and inhibits fat deposition and fibrosis by regulating the wnt signaling pathway to treat rotator cuff tears via docking with SFRP1 [PDF]
Molecular MedicineBackground Rotator cuff tears (RCTs) are among the most common musculoskeletal disorders that affect quality of life. This study aimed to investigate the efficacy of ginsenoside Rb1 in RCTs and the mechanisms involved.
Yuesong Yin, Hai Hu, Yian Yang, Song Wu
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Production of Gypenoside XVII from Ginsenoside Rb1 by Enzymatic Transformation and Their Anti-Inflammatory Activity In Vitro and In Vivo [PDF]
Molecules, 2023 The enzymatic transformation of the sugar moiety of the gypenosides provides a new way to obtain more pharmacologically active components. A gene encoding a family 1 glycosyl hydrolase from Bifidobacterium dentium was cloned and expressed in Escherichia ...
Kailu Zhou +4 more
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Ginsenoside Rb1 attenuates coronary microvascular inflammatory injury via NDUFS4-SIRT5-DUSP1-mediated mitochondrial quality control in a murine ischemia-reperfusion model [PDF]
Journal of Ginseng ResearchBackground: Ginsenoside Rb1 is a prominent bioactive component in traditional Chinese medicine. Purpose: This study investigated the molecular mechanisms underlying the protective effects of Ginsenoside Rb1 on endothelium during ischemia-reperfusion (I/R)
Xiangyi Pu +7 more
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Ginsenoside Rb1, salvianolic acid B and their combination modulate gut microbiota and improve glucolipid metabolism in high-fat diet induced obese mice [PDF]
PeerJ, 2021 Background To observe the effect of ginsenoside Rb1, salvianolic acid B and their combination on glucolipid metabolism and structural changes of gut microbiota. Methods Eight-week-old C57BL/6J mice were fed 45% high-fat diet to induce obesity.
Ying Bai +11 more
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Frontiers in Pharmacology, 2022 Ginsenoside Rb1, a main component of ginseng, is often transformed into ginsenoside CK by intestinal flora to exert various pharmacological activity. However, it remains unclear whether ginsenoside CK is responsible for the anti-gastric cancer effect of ...
Yan Wan +8 more
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International Journal of Oral Science, 2022 Ginsenoside Rb1, the effective constituent of ginseng, has been demonstrated to play favorable roles in improving the immunity system. However, there is little study on the osteogenesis and angiogenesis effect of Ginsenoside Rb1.
Yuqiong Wu +5 more
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Frontiers in Pharmacology, 2022 Triptolide (TP) is the major bioactive compound extracted from Tripterygium wilfordii Hook F. It exerts anti-inflammatory, antirheumatic, antineoplastic, and neuroprotective effects.
Hulinyue Peng +9 more
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Ginsenoside Rb1 attenuates diabetic retinopathy in streptozotocin-induced diabetic rats [PDF]
Acta Cirúrgica Brasileira, 2019 Purpose: To investigated the effects of ginsenoside Rb1 on diabetic retinopathy in streptozotocin-induced diabetic rats. Methods: Diabetes was induced by a single intraperitoneal injection of streptozotocin (80 mg/kg) in male Wistar rats.
Changxia Dong +5 more
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