Results 21 to 30 of about 5,453 (156)

Anxiolytic and Antidepressant Activities of Ginsenoside Rb1 [PDF]

Biomolecules and Therapeutics, 2007
The psychopharmacological profile of ginsenosides has not yet been confirmed systematically although various neuropharmacological activities associated with them have been investigated. In the present study, the psychological activities of Rb1 were investigated to evaluate whether it can be used in treatment or prevention of psychological disorders ...
Jong-Hyun Choi, Seo-Young Yoon, Eun-Joo Choi, Yim-Seon Ryu, Hong-Sook Ko, Dong-Sool Yim, Youl Her, Yong-Soo Lee, Mi-Ryoung Song, Jae-Hoon Cheong   +9 more
openaire   +1 more source

Ginsenoside Rb1 attenuates activated microglia-induced neuronal damage

Neural Regeneration Research, 2014
The microglia-mediated inflammatory reaction promotes neuronal damage under cerebral ischemia/hypoxia conditions. We therefore speculated that inhibition of hypoxia-induced microglial activation may alleviate neuronal damage. To test this hypothesis, we co-cultured ginsenoside Rb1, an active component of ginseng, and cortical neurons.
Ke, Lining, Guo, Wei, Xu, Jianwen, Zhang, Guodong, Wang, Wei, Huang, Wenhua   +5 more
openaire   +2 more sources

Ginsenoside Rb1 as a neuroprotective agent: A review

Brain Research Bulletin, 2016
Ginsenosides represent the major bioactive components of ginseng. These triterpenoid saponins have been shown to exert numerous beneficial effects on the human body. Recent evidences suggest that ginsenosides may be useful for the management and treatment of several diseases of the central nervous system (CNS).
Touqeer, Ahmed, Syed Hammad, Raza, Afifa, Maryam, William N, Setzer, Nady, Braidy, Seyed Fazel, Nabavi, Marcos Roberto, de Oliveira, Seyed Mohammad, Nabavi   +7 more
openaire   +2 more sources

Enzymatic formation of compound-K from ginsenoside Rb1 by enzyme preparation from cultured mycelia of Armillaria mellea

Journal of Ginseng Research, 2016
Background: Minor saponins or human intestinal bacterial metabolites, such as ginsenosides Rg3, F2, Rh2, and compound K, are more pharmacologically active than major saponins, such as ginsenosides Rb1, Rb2, and Rc.
Jitendra Upadhyaya, Min-Ji Kim, Young-Hoi Kim, Sung-Ryong Ko, Hee-Won Park, Myung-Kon Kim   +5 more
doaj   +1 more source

Antiobesity and Antihyperglycemic Effects of Ginsenoside Rb1 in Rats [PDF]

Diabetes, 2010
OBJECTIVE Obesity and type 2 diabetes are national and worldwide epidemics. Because currently available antiobesity and antidiabetic drugs have limited efficacy and/or safety concerns, identifying new medicinal agents, such as ginsenoside Rb1 (Rb1) as reported here, offers exciting possibilities for future ...
Xiong, Ye, Shen, Ling, Liu, Kristina J., Tso, Patrick, Xiong, Yuqing, Wang, Guangji, Woods, Stephen C., Liu, Min   +7 more
openaire   +2 more sources

Ginsenoside Rb1 Enhances Plaque Stability and Inhibits Adventitial Vasa Vasorum via the Modulation of miR-33 and PEDF

Frontiers in Cardiovascular Medicine, 2021
Background: Atherosclerosis is closely associated with proliferation of the adventitial vasa vasorum, leading to the atherosclerotic plaque progression and vulnerability.
Xiaoyan Yang, Xiaoyan Yang, Lei Wang, Zihao Zhang, Jiayi Hu, Xiaoling Liu, Hao Wen, Hao Wen, Minghao Liu, Minghao Liu, Xue Zhang, Xue Zhang, Hongyan Dai, Mei Ni, Rui Li, Rong Guo, Lei Zhang, Xiaorong Luan, Huili Lin, Mei Dong, Huixia Lu   +20 more
doaj   +1 more source

Western Blotting for Ginseng Saponins, Ginsenosides Using Anti-ginsenoside Rb1 Monoclonal Antibody.

Biological and Pharmaceutical Bulletin, 1999
Ginsenosides separated by silica gel TLC were blotted to a polyvinylidene difluoride (PVDF) membrane which was treated with a NaIO4 solution followed by bovine serum albumine (BSA), resulting in a ginsenoside-BSA conjugate on a PVDF membrane. The blotted bands were stained with monoclonal antibody (MAb).
N, Fukuda, H, Tanaka, Y, Shoyama
openaire   +3 more sources

Ginsenoside Rb1 Protects Against Diabetic Cardiomyopathy by Regulating the Adipocytokine Pathway

Journal of Inflammation Research, 2022
Chenyang Zhang,1 Meixin Han,2 Xuelian Zhang,1 Hongna Tong,1 Xiaobo Sun,1 Guibo Sun1 1Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 2College of Pharmacy,
Zhang C, Han M, Zhang X, Tong H, Sun X, Sun G   +5 more
doaj  

Ginsenoside Rb1 protects dopaminergic neurons from inflammatory injury induced by intranigral lipopolysaccharide injection

Neural Regeneration Research, 2019
Accumulating studies suggest that neuroinflammation characterized by microglial overactivation plays a pivotal role in the pathogenesis of Parkinson’s disease.
Da-Wei Li, Fa-Zhan Zhou, Xian-Chang Sun, Shu-Chen Li, Jin-Bin Yang, Huan-Huan Sun, Ai-Hua Wang   +6 more
doaj   +1 more source

Ginsenoside Rb1 alleviates aluminum chloride-induced rat osteoblasts dysfunction [PDF]

Toxicology, 2016
Osteoblasts dysfunction, induced by aluminum (Al), plays a critical role in the osteoporosis etiology. Ginsenoside Rb1 (Rb1) has the therapeutic properties for osteoporosis. This study aimed to assess the efficiency of Rb1 in ameliorating Al-induced osteoblasts dysfunction.
Yanzhu, Zhu, Chongwei, Hu, Peihe, Zheng, Liguang, Miao, Xijun, Yan, Haitao, Li, Zhongying, Wang, Bing, Gao, Yanfei, Li   +8 more
openaire   +2 more sources