Ginseng Gintonin Attenuates Lead-Induced Rat Cerebellar Impairments during Gestation and Lactation [PDF]
Biomolecules, 2020 Gintonin, a novel ginseng-derived lysophosphatidic acid receptor ligand, improves brain functions and protects neurons from oxidative stress. However, little is known about the effects of gintonin against Pb-induced brain maldevelopment.
Sung Min Nam +7 more
doaj +5 more sources
Gintonin-Enriched Panax ginseng Extract Induces Apoptosis in Human Melanoma Cells by Causing Cell Cycle Arrest and Activating Caspases [PDF]
FoodsGintonin, a non-saponin glycolipoprotein from Panax ginseng, acts as a lysophosphatidic acid ligand. However, its anticancer effects, especially in melanoma, remain unclear.
Su-Hyun Lee +8 more
doaj +4 more sources
A novel protocol for batch-separating gintonin-enriched, polysaccharide-enriched, and crude ginsenoside-containing fractions from Panax ginseng [PDF]
Journal of Ginseng Research, 2023 Background: Ginseng contains three active components: ginsenosides, gintonin, and polysaccharides. After the separation of 1 of the 3 ingredient fractions, other fractions are usually discarded as waste. In this study, we developed a simple and effective
Rami Lee +11 more
doaj +3 more sources
Characteristics of Gintonin-Mediated Membrane Depolarization of Pacemaker Activity in Cultured Interstitial Cells of Cajal [PDF]
Cellular Physiology and Biochemistry, 2014 Background/Aims: Ginseng regulates gastrointestinal (GI) motor activity but the underlying components and molecular mechanisms are unknown. We investigated the effect of gintonin, a novel ginseng-derived G protein-coupled lysophosphatidic acid (LPA ...
Byung Joo Kim +11 more
doaj +5 more sources
Journal of Ginseng Research, 2021 Background: Gintonin, isolated from ginseng, acts as a ginseng-derived lysophosphatidic acid (LPA) receptor ligand and elicits the [Ca2+]i transient through six LPA receptor subtypes (LPARSs). However, the long-term effects of gintonin-enriched fraction (
Rami Lee +9 more
doaj +4 more sources
Retracted: Oral Administration of Gintonin Protects the Brains of Mice against Aβ-Induced Alzheimer Disease Pathology: Antioxidant and Anti-Inflammatory Effects. [PDF]
Oxid Med Cell Longev, 2023 Oxidative Medicine and Cellular Longevity, Volume 2023, Issue 1, 2023.
Longevity OMAC.
europepmc +4 more sources
Gintonin stimulates gliotransmitter release in cortical primary astrocytes [PDF]
Neuroscience Letters, 2015 Lysophosphatidic acid (LPA) is a simple and minor phospholipid, but serves as a lipid-derived neurotransmitter via activation of G protein-coupled LPA receptors. Astrocytes abundantly express LPA receptors and contain gliotransmitters that modulate astrocyte-neuron interactions. Gintonin is a novel ginseng-derived G protein-coupled LPA receptor ligand.
Hyunsook, Kim +9 more
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Gintonin-Induced Wound-Healing-Related Responses Involve Epidermal-Growth-Factor-like Effects in Keratinocytes. [PDF]
Int J Mol Sci, 2023 Epidermal growth factor (EGF) receptor activation and related downstream signaling pathways are known to be one of the major mechanisms of the proliferation and migration of keratinocytes. The heparin-binding EGF-like growth factor (HB-EGF) binds to EGF receptors and stimulates keratinocyte proliferation and migration.
Won KJ +5 more
europepmc +5 more sources
Gintonin absorption in intestinal model systems
Journal of Ginseng Research, 2018 Background: Recently, we identified a novel ginseng-derived lysophosphatidic acid receptor ligand, called gintonin. We showed that gintonin induces [Ca2+]i transient-mediated morphological changes, proliferation, and migration in cells expressing ...
Byung-Hwan Lee +7 more
doaj +3 more sources
Ginseng gintonin, aging societies, and geriatric brain diseases
Integrative Medicine Research, 2021 Background: A dramatic increase in aging populations and low birth rates rapidly drive aging societies and increase aging-associated neurodegenerative diseases.
Sun-Hye Choi +8 more
doaj +3 more sources