Effects of gintonin-enriched fraction on hippocampal gene expressions
Integrative Medicine Research, 2021 Background: Recently, gintonin and gintonin-enriched fraction (GEF) have been isolated from ginseng, a herbal medicine. Gintonin induces [Ca2+]i transition in cultured hippocampal neurons and stimulates acetylcholine release through LPA receptor ...
Rami Lee +8 more
doaj +3 more sources
Bioactive lipids in gintonin-enriched fraction from ginseng
Journal of Ginseng Research, 2019 Background: Ginseng is a traditional herbal medicine for human health. Ginseng contains a bioactive ligand named gintonin. The active ingredient of gintonin is lysophosphatidic acid C18:2 (LPA C18:2).
Hee-Jung Cho +7 more
doaj +3 more sources
Gintonin-Enriched Fraction Suppresses Heat Stress-Induced Inflammation through LPA Receptor [PDF]
Molecules, 2020 Heat stress can be caused by various environmental factors. When exposed to heat stress, oxidative stress and inflammatory reaction occur due to an increase of reactive oxygen species (ROS) in the body.
Sungwoo Chei +7 more
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A brief method for preparation of gintonin-enriched fraction from ginseng
Journal of Ginseng Research, 2015 Background: Ginseng has been used as a tonic for invigoration of the human body. In a previous report, we identified a novel candidate responsible for the tonic role of ginseng, designated gintonin.
Sun-Hye Choi +10 more
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Ginseng Nanosizing: The Second Spring of Ginseng Therapeutic Applications [PDF]
AntioxidantsPlant-derived vesicles offer several advantages, including high yield, low cost, ethical compatibility, safety, and potential health benefits. These advantages enable them to overcome technological limitations associated with vesicles of mammalian origin.
Jian Wang +8 more
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Amelioration of muscle wasting by gintonin in cancer cachexia
Neoplasia: An International Journal for Oncology Research, 2021 Cancer cachexia is characterized by systemic inflammation, protein degradation, and loss of skeletal muscle. Despite extensive efforts to develop therapeutics, only few effective treatments are available to protect against cancer cachexia. Here, we found
Yoseph Toni Wijaya +4 more
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Gintonin stimulates autophagic flux in primary cortical astrocytes
Journal of Ginseng Research, 2020 Background: Gintonin (GT), a novel ginseng-derived exogenous ligand of lysophosphatidic acid (LPA) receptors, has been shown to induce cell proliferation and migration in the hippocampus, regulate calcium-dependent ion channels in the astrocytes, and ...
Md. Ataur Rahman +3 more
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The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases [PDF]
Frontiers in Aging, 2023 The pathophysiology of different neurodegenerative illnesses is significantly influenced by the polarization regulation of microglia and macrophages.
Samar F. Darwish +5 more
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Ongoing Research on the Role of Gintonin in the Management of Neurodegenerative Disorders [PDF]
Cells, 2020 Neurodegenerative disorders, namely Parkinson’s disease (PD), Huntington’s disease (HD), Alzheimer’s disease (AD), and multiple sclerosis (MS), are increasingly major health concerns due to the increasingly aged population worldwide.
Muhammad Ikram +3 more
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A novel protocol for batch-separating gintonin-enriched, polysaccharide-enriched, and crude ginsenoside-containing fractions from Panax ginseng [PDF]
Journal of Ginseng Research, 2023 Background: Ginseng contains three active components: ginsenosides, gintonin, and polysaccharides. After the separation of 1 of the 3 ingredient fractions, other fractions are usually discarded as waste. In this study, we developed a simple and effective
Rami Lee +11 more
doaj +2 more sources