Gintonin Alleviates HCl/Ethanol- and Indomethacin-Induced Gastric Ulcers in Mice. [PDF]
Int J Mol Sci, 2023 Gintonin, newly extracted from ginseng, is a glycoprotein that acts as an exogenous lysophosphatidic acid (LPA) receptor ligand. This study aimed to demonstrate the in vivo preventive effects of gintonin on gastric damage. ICR mice were randomly assigned to five groups: a normal group (received saline, 0.1 mL/10 g, p.o.); a control group (administered ...
Cho HS +9 more
europepmc +3 more sources
Journal of Ginseng Research, 2022 Background: Gintonin-enriched fraction (GEF), a non-saponin fraction of ginseng, is a novel glycolipoprotein rich in hydrophobic amino acids. GEF has recently been shown to regulate lipid metabolism and browning in adipocytes; however, the mechanisms ...
Heegu Jin +3 more
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Potential Anti-Inflammatory Effects of Gintonin-Enriched Fraction in TNF-α-Stimulated Keratinocytes. [PDF]
Int J Mol SciLee R +5 more
europepmc +3 more sources
Corrigendum to “Gintonin regulates inflammation in human IL-1β-stimulated fibroblast-like synoviocytes and carrageenan/kaolin-induced arthritis in rats through LPAR2”[J Ginseng Res 45(5) September 2021, 575-582] [PDF]
Journal of Ginseng Research, 2023 Mijin Kim +5 more
doaj +2 more sources
Gintonin exerts effects via LPAR1/3 and the MEK signaling pathway
International Journal of Biological MacromoleculesBaiCheng Chen +4 more
openaire +2 more sources
Preparation of Red Ginseng Marc-Derived Gintonin and Its Application as a Skin Nutrient. [PDF]
Nutrients, 2023 Ginseng is one of the traditional herbal medicines for tonic. Gintonin is a new material derived from white/red ginseng and its lysophosphatidic acids (LPAs) play as a ligand for G protein-coupled LPA receptors. Korean red ginseng marc (KRGM) is a by-product after the KRG processes.
Lee R +9 more
europepmc +3 more sources
Biological evidence of gintonin efficacy in memory disorders
Pharmacological Research, 2021 Gintonin is a novel glycolipoprotein, which has been abundantly found in the root of Korean ginseng. It holds lysophosphatidic acids (LPAs), primarily identified LPA C18:2, and is an exogenous agonist of LPA receptors (LPARs). Gintonin maintains blood-brain barrier integrity, and it has recently been studied in several models of neurodegenerative ...
Md. Jakaria +5 more
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An Edible Gintonin Preparation from Ginseng [PDF]
Journal of Ginseng Research, 2011 Ginseng, the root of Panax ginseng, is one of the oldest herbal medicines. It has a variety of physiological and pharmacological effects. Recently, we isolated a subset of glycolipoproteins that we designated gintonin, and demonstrated that it induced transient change in intracellular calcium concentration ([Ca(2+)]i) in cells via G-protein-coupled ...
Choi, Sun-Hye +7 more
openaire +2 more sources
Journal of Ginseng Research, 2021 Background: Gintonin is a ginseng-derived exogenous G-protein–coupled lysophosphatidic acid (LPA) receptor ligand, which exhibits in vitro and in vivo functions against Alzheimer disease (AD) through lysophosphatidic acid 1/3 receptors.
Sun-Hye Choi +9 more
doaj +1 more source
Lipid-Enriched Gintonin from Korean Red Ginseng Marc Alleviates Obesity via Oral and Central Administration in Diet-Induced Obese Mice. [PDF]
NutrientsYasmin T +9 more
europepmc +3 more sources