Results 121 to 130 of about 10,013 (222)

GIRK2 splice variants and neuronal G protein-gated K+ channels: implications for channel function and behavior

Scientific Reports, 2017
Many neurotransmitters directly inhibit neurons by activating G protein-gated inwardly rectifying K+ (GIRK) channels, thereby moderating the influence of excitatory input on neuronal excitability. While most neuronal GIRK channels are formed by GIRK1 and
Ezequiel Marron Fernandez de Velasco, Lei Zhang, Baovi N. Vo, Megan Tipps, Shannon Farris, Zhilian Xia, Allison Anderson, Nicholas Carlblom, C. David Weaver, Serena M. Dudek, Kevin Wickman   +10 more
doaj   +1 more source

Modulation of Neuronal GIRK Channels by Cholesterol

The FASEB Journal, 2015
In recent years, cholesterol emerged as a major regulator of ion channel function. The most common effect of cholesterol on ion channels is a decrease in channel activity. We have recently shown that unexpectedly cholesterol enrichment up‐regulates G‐protein gated inwardly rectifying potassium (GIRK or Kir3) currents in atrial ...
Avia Rosenhouse‐Dantsker, Anna Bukiya
openaire   +1 more source

Serotonin (5‐Hydroxytryptamine): Metabolism, Signaling, Biological Functions, Diseases, and Emerging Therapeutic Opportunities

MedComm, Volume 6, Issue 9, September 2025.
This article reviews the roles of 5‐HT metabolism, 5‐HT receptors, and their related signaling pathways in normal physiology and various diseases, and explores their potential value in disease treatment, providing a reference basis for research and clinical treatment in related fields. ABSTRACT Serotonin (5‐hydroxytryptamine; 5‐HT) is an evolutionarily
Yuxin Zhang, Nan Wang, Louqian Zhang, Yan Zhuang, Qilei Xin, Xiaosong Gu, Chunping Jiang, Junhua Wu   +7 more
wiley   +1 more source

G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channel Activation by the p75 Neurotrophin Receptor Is Required for Amyloid β Toxicity

Frontiers in Neuroscience, 2017
Alzheimer's disease is characterized by cognitive decline, neuronal degeneration, and the accumulation of amyloid-beta (Aβ). Although, the neurotoxic Aβ peptide is widely believed to trigger neuronal dysfunction and degeneration in Alzheimer's disease ...
Linda M. May, Victor Anggono, Victor Anggono, Helen M. Gooch, Se E. Jang, Se E. Jang, Dusan Matusica, Dusan Matusica, Georg M. Kerbler, Frederic A. Meunier, Frederic A. Meunier, Pankaj Sah, Elizabeth J. Coulson, Elizabeth J. Coulson, Elizabeth J. Coulson   +14 more
doaj   +1 more source

GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Mechanisms promoting the compartmentalization of G-protein signaling are poorly understood in native cells. This study examined muscarinic (M2R) and adenosine (A1R) receptor signaling to a common effector—the G protein-gated inwardly ...
Allison Anderson, I. Masuho, Ezequiel Marron Fernandez de Velasco, A. Nakano, L. Birnbaumer, K. Martemyanov, K. Wickman   +6 more
semanticscholar   +1 more source

The Quinoline Photoremovable Group (PPG) Platform—A Medicinal Chemist's Approach for Photocage Development and Applications

Medicinal Research Reviews, Volume 45, Issue 5, Page 1423-1451, September 2025.
ABSTRACT Photoremovable protecting groups (PPGs) offer a straightforward solution for the temporary inactivation of biologically active substrates and their subsequent controlled release by light irradiation. Their relatively easy design and mode of application have made them useful tools for studying dynamic biological processes in vitro and in vivo ...
Bence Kontra, Zoltán Mucsi, Janez Ilaš, Petra Dunkel   +3 more
wiley   +1 more source

The K+ channel GIRK2 is both necessary and sufficient for peripheral opioid‐mediated analgesia

EMBO Molecular Medicine, 2013
The use of opioid agonists acting outside the central nervous system (CNS) is a promising therapeutic strategy for pain control that avoids deleterious central side effects such as apnea and addiction.
Dinah Nockemann, Morgane Rouault, Dominika Labuz, Philip Hublitz, Kate McKnelly, Fernanda C. Reis, Christoph Stein, Paul A. Heppenstall   +7 more
doaj   +1 more source

Oversight, influence and Mesopotamian connections to Armenia across the Sasanian and early Islamic periods [PDF]

, 2015
Postprin
Greenwood, Timothy William
core  

DAMGO Modulates two-pore domain K+ channels in the substantia gelatinosa neurons of rat spinal cord [PDF]

, 2016
The analgesic mechanism of opioids is known to decrease the excitability of substantia gelatinosa (SG) neurons receiving the synaptic inputs from primary nociceptive afferent fiber by increasing inwardly rectifying K+ current.
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core   +1 more source

Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light

Medicinal Research Reviews, Volume 45, Issue 5, Page 1407-1422, September 2025.
ABSTRACT Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward‐motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of various neurological and psychiatric disorders, like Parkinson's disease, schizophrenia, depression, and addictions ...
Galyna Maleeva, Carlo Matera, Silvia Roda, Alessio Colleoni, Marco De Amici, Pau Gorostiza   +5 more
wiley   +1 more source