Results 131 to 140 of about 10,013 (222)

Voltage-Dependent Dopamine Potency at D1-Like Dopamine Receptors

Frontiers in Pharmacology, 2020
In recent years, transmembrane voltage has been found to modify agonist potencies at several G protein-coupled receptors (GPCRs). Whereas the voltage sensitivities of the Gαi/o-coupled dopamine D2-like receptors (D2R, D3R, D4R) have previously been ...
Richard Ågren, Kristoffer Sahlholm, Kristoffer Sahlholm, Kristoffer Sahlholm   +3 more
doaj   +1 more source

Reductionism redux

eLife, 2016
Experiments on artificial membranes are revealing many details about the workings of a family of potassium ion channels called GIRK channels.
Christopher Miller
doaj   +1 more source

Association Between KCNJ6 (GIRK2) Gene Polymorphism rs2835859 and Post-operative Analgesia, Pain Sensitivity, and Nicotine Dependence

Journal of Pharmacological Sciences, 2014
.: G-protein–activated inwardly rectifying potassium (GIRK) channels are expressed in many tissues and activated by several Gi/o protein–coupled receptors, such as opioid and dopamine receptors, and thus are known to be involved in the modulation of ...
Daisuke Nishizawa, Ken-ichi Fukuda, Shinya Kasai, Yasukazu Ogai, Junko Hasegawa, Naomi Sato, Hidetaka Yamada, Fumihiko Tanioka, Haruhiko Sugimura, Masakazu Hayashida, Kazutaka Ikeda   +10 more
doaj   +1 more source

A Comparison of the Effects of Different Doses of GABAB Receptor Ligands on Spatial Learning and Memory and Memory Flexibility

, 2015
The principal inhibitory neurotransmitter in the brain, gamma amino-butyric acid (GABA), mediates several types of learning and memory. Of the two main receptor subtypes for GABA, the in vivo role of GABAB receptor in learning and memory is less well ...
Heaney, Chelcie
core   +1 more source

A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ.

PLoS Computational Biology, 2015
G protein-gated K+ channels (GIRK; Kir3), activated by Gβγ subunits derived from Gi/o proteins, regulate heartbeat and neuronal excitability and plasticity.
Daniel Yakubovich, Shai Berlin, Uri Kahanovitch, Moran Rubinstein, Isabella Farhy-Tselnicker, Boaz Styr, Tal Keren-Raifman, Carmen W Dessauer, Nathan Dascal   +8 more
doaj   +1 more source

Self-Verifying Variational Quantum Simulation of the Lattice Schwinger Model

, 2019
Hybrid classical-quantum algorithms aim at variationally solving optimisation problems, using a feedback loop between a classical computer and a quantum co-processor, while benefitting from quantum resources.
Blatt, Rainer, Brydges, Tiff, Joshi, Manoj K., Jurcevic, Petar, Kokail, Christian, Maier, Christine, Muschik, Christine A., Roos, Christian F., Silvi, Pietro, van Bijnen, Rick, Zoller, Peter   +10 more
core   +1 more source

Endogenous RGS proteins enhance acute desensitization of GABAB receptor-activated GIRK currents in HEK-293T cells [PDF]

, 2018
The coupling of GABAB receptors to G-protein-gated inwardly rectifying potassium (GIRK) channels constitutes an important inhibitory pathway in the brain.
Berton, Frédérique, Lüscher, Christian, Mutneja, Manpreet, Slesinger, Paul, Suen, Ka-Fai   +4 more
core  

Somatodendritic integration under increased network activity in layer 5 pyramidal cells of the somatosensory cortex [PDF]

, 2018
Integrative properties of single neurons have been extensively studied in acute brain slices. However, these preparations are characterized by extremely low levels of synaptic and action potential activity. In comparison to in vivo, reduced intracortical
Berger, Thomas, Neubauer, Florian
core  

Gating of GIRK Channels [PDF]

Neuron, 2003
Sadja, Rona, Alagem, Noga, Reuveny, Eitan   +2 more
openaire   +1 more source

Structural determinants of the direct inhibition of GIRK channels by Sigma-1 receptor antagonist

bioRxiv, 2023
Chang Liu, I-Shan Chen, M. Tateyama, Yoshihiro Kubo   +3 more
semanticscholar   +1 more source