Results 71 to 80 of about 10,013 (222)
RGS proteins maintain robustness of GPCR‐GIRK coupling [PDF]
The FASEB Journal, 2012 Objective To elucidate the mechanism underlying sustained GPCR‐GIRK coupling under RGS actions. Results Regulators of G‐protein signaling (RGS) are GTPase activating proteins (GAP) that reduce response amplitudes of activated G‐protein
Chuang, Huai-hu, Chuang, Alexander Y.
openaire +1 more source
A discrete alcohol pocket involved in GIRK channel activation [PDF]
Nature Neuroscience, 2009 Ethanol modifies neural activity in the brain by modulating ion channels. Ethanol activates G protein-gated inwardly rectifying K(+) channels, but the molecular mechanism is not well understood. Here, we used a crystal structure of a mouse inward rectifier containing a bound alcohol and structure-based mutagenesis to probe a putative alcohol-binding ...
Aryal, Prafulla +3 more
openaire +2 more sources
Addiction Biology, 2022 Drug‐induced neuroadaptations in the prefrontal cortex (PFC) have been implicated in drug‐associated memories that motivate continued drug use. Chronic cocaine exposure increases pyramidal neuron excitability in the prelimbic subregion of the PFC (PL ...
T. Rose +3 more
semanticscholar +1 more source
eLife, 2014 In the hippocampus, the inhibitory neurotransmitter GABA shapes the activity of the output pyramidal neurons and plays important role in cognition.
Olga Ostrovskaya +6 more
doaj +1 more source
Exploring the correlation between GIRK proteins and pain behavior in trigeminal neuralgia in mice
生物医学转化, 2023 Objective Trigeminal neuralgia is the most common maxillofacial pain syndrome, and its etiology has not been fully understood. In this paper, we focus on the role and expression of G protein-gated inwardly rectifying potassium channel (GIRK) protein in ...
Pan Xuqiang, Han Liang, Shi Tiejun
doaj +1 more source
Voltage sensitivity of dopamine D2-like receptors [PDF]
, 2011 G protein coupled receptors (GPCRs) mediate a multitude of responses serving hormonal, neurotransmitter, and sensory functions. These receptors are important drug targets; in fact, about 27 % of prescribed drugs are GPCR ligands.
Sahlholm, Kristoffer
core +1 more source
Small Molecule Modulation of Brain GIRK Channels [PDF]
Biophysical Journal, 2017 G protein-gated inwardly rectifying potassium (GIRK) channels regulate cellular excitability in the heart and brain. Stimulation of G protein-coupled receptors that couple to Gi/o (pertussis toxin-sensitive) G proteins is the primary mechanism of activating GIRK channels.
Ian W. Glaaser, Paul A. Slesinger
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Frontiers in Physiology, 2014 Alcohol (ethanol)-induced behaviors arise from direct interaction of alcohol with discrete protein cavities within brain proteins. Recent structural and biochemical studies have provided new insights into the mechanism of alcohol-dependent activation of ...
Karthik eBodhinathan, Paul A Slesinger
doaj +1 more source
Elevated alpha-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells [PDF]
, 2015 We have assessed the impact of α-synuclein overexpression on the differentiation potential and phenotypic signatures of two neural-committed induced pluripotent stem cell lines derived from a Parkinson´s disease patient with a triplication of the human ...
Arndt Jovin, D. J. +12 more
core +4 more sources
Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis
Advanced Science, EarlyView.ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai +15 more
wiley +1 more source