Results 81 to 90 of about 15,686 (159)

A dominant loss-of-function GJA1 (Cx43) mutant impairs parturition in the mouse

, 2009
Expression of GJA1 (commonly known as connexin43 or Cx43), a major myometrial gap junction protein, is upregulated before the onset of delivery, suggesting an essential role for Cx43-mediated gap junctional intercellular communication (GJIC) in normal ...
Wang, Hong-Xing, Kidder, Gerald M., Laird, Dale W, Plante, Isabelle, Bai, Douglin, Tong, Dan, Lu, Xuerong, Lui, Ed   +7 more
core   +1 more source

Estrogen receptor alpha isoform ERdelta7 in myometrium modulates uterine quiescence during pregnancyResearch in context

EBioMedicine, 2019
Background: Circulating estrogen (E2) levels are high throughout pregnancy and increase towards term, however its local tissue specific actions vary across gestation.
Prashanth Anamthathmakula, Chandrashekara Kyathanahalli, Judith Ingles, Sonia S. Hassan, Jennifer C. Condon, Pancharatnam Jeyasuria   +5 more
doaj   +1 more source

KLF2 controls proliferation and apoptosis of human spermatogonial stem cells via targeting GJA1

iScience
Summary: Human spermatogonial stem cells (SSCs) are essential for spermatogenesis and male fertility. However, molecular mechanisms regulating fate determinations of human SSCs remain elusive.
Wei Chen, Yinghong Cui, Chunyun Li, Caimei He, Li Du, Wei Liu, Zuping He   +6 more
doaj   +1 more source

Enhanced periosteal and endocortical responses to axial tibial compression loading in conditional connexin43 deficient mice.

PLoS ONE, 2012
The gap junction protein, connexin43 (Cx43) is involved in mechanotransduction in bone. Recent studies using in vivo models of conditional Cx43 gene (Gja1) deletion in the osteogenic linage have generated inconsistent results, with Gja1 ablation ...
Susan K Grimston, Marcus P Watkins, Michael D Brodt, Matthew J Silva, Roberto Civitelli   +4 more
doaj   +1 more source

Autoregulation of Connexin43 Gap Junction Formation by Internally Translated Isoforms

Cell Reports, 2013
During each heartbeat, intercellular electrical coupling via connexin43 (Cx43) gap junctions enables synchronous cardiac contraction. In failing hearts, impaired Cx43 trafficking reduces gap junction coupling, resulting in arrhythmias.
James W. Smyth, Robin M. Shaw
doaj   +1 more source

Butylboronic acid promotes cell proliferation, alkaline phosphatase activity, and expression of GJA1, ALP, and NaBC1 in human dental pulp cells in vitro

Frontiers in Dental Medicine
The objective of this study is to investigate the effects of n-butylboronic acid (n-BA) on the proliferative activity, alkaline phosphatase activity, expression of hard tissue formation related genes, ALP and GJA1, and boron transporter gene, NaBC1, in ...
Takashi Nakano, Hidenori Hamba, Takashi Muramatsu   +2 more
doaj   +1 more source

Structural Assessment of PITX2, FOXC1, CYP1B1, and GJA1 Genes in Patients with Axenfeld-Rieger Syndrome with Developmental Glaucoma

, 2006
PURPOSE. Axenfeld-Rieger (AR) is an autosomal dominant disorder with phenotypic heterogeneity characterized by anterior segment dysgenesis, facial bone defects, and redundant periumbilical skin.
Bianca Kneipp, Vital Paulino Costa, José Paulo Cabral De Vasconcellos, Mônica Barbosa De Melo, Fernando Ferreira Costa, Carlos Alberto Longui, Wener Cella   +6 more
core  

Connexin43 in mesenchymal lineage cells regulates body adiposity and energy metabolism in mice

JCI Insight
Connexin43 (Cx43) is the most abundant gap junction protein present in the mesenchymal lineage. In mature adipocytes, Cx43 mediates white adipose tissue (WAT) beiging in response to cold exposure and maintains the mitochondrial integrity of brown adipose
Seung-Yon Lee, Francesca Fontana, Toshifumi Sugatani, Ignacio Portales Castillo, Giulia Leanza, Ariella Coler-Reilly, Roberto Civitelli   +6 more
doaj   +1 more source

Megalopapilla in oculodentodigital dysplasia: a novel ocular finding in a rare genetic disorder

The Turkish Journal of Pediatrics
Background. Oculodentodigital dysplasia (ODDD) is a rare autosomal dominant disorder caused by pathogenic variants in the GJA1 gene and characterized by variable craniofacial, dental, digital, and ocular abnormalities.
Figen Bezci Aygun, Gunes Deniz Ulas, Izlem Ozturan, Sibel Kadayifcilar   +3 more
doaj   +1 more source

Novel mutations in GJA1 cause oculodentodigital syndrome

, 2008
Oculodentodigital syndrome (ODD) is a rare, usually autosomal-dominant disorder that is characterized by developmental abnormalities of the face, eyes, teeth, and limbs.
Richardson, R. J., Barron, M. J., Richardson, R J, Dixon, M J, Butterworth, J., Butterworth, J, Fenwick, A., Fenwick, A, Barron, M J, Dixon, M. J.   +9 more
core   +1 more source