Caspase-2 is upregulated after sciatic nerve transection and its inhibition protects dorsal root ganglion neurons from Apoptosis after serum withdrawal [PDF]
, 2013 Sciatic nerve (SN) transection-induced apoptosis of dorsal root ganglion neurons (DRGN) is one factor determining the efficacy of peripheral axonal regeneration and the return of sensation.
A Madro +48 more
core +15 more sources
Ferroptosis in Parkinson's disease: glia-neuron crosstalk.
Trends in Molecular Medicine, 2022 Parkinson's disease (PD) is characterized by dopaminergic (DA) neuron loss and the formation of cytoplasmic protein inclusions. Although the exact pathogenesis of PD is unknown, iron dyshomeostasis has been proposed as a potential contributing factor ...
Zhang-Li Wang +3 more
semanticscholar +1 more source
The “Neuro-Glial-Vascular” Unit: The Role of Glia in Neurovascular Unit Formation and Dysfunction
Frontiers in Cell and Developmental Biology, 2021 The neurovascular unit (NVU) is a complex multi-cellular structure consisting of endothelial cells (ECs), neurons, glia, smooth muscle cells (SMCs), and pericytes.
E. Kugler, J. Greenwood, R. MacDonald
semanticscholar +1 more source
Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice.
Cell, 2020 Conversion of glial cells into functional neurons represents a potential therapeutic approach for replenishing neuronal loss associated with neurodegenerative diseases and brain injury.
Haibo Zhou +21 more
semanticscholar +1 more source
Development of myelinating glia: An overview
Glia, 2022 Myelin is essential to nervous system function, playing roles in saltatory conduction and trophic support. Oligodendrocytes (OLs) and Schwann cells (SCs) form myelin in the central and peripheral nervous systems respectively and follow different ...
Carlo D. D. Cristobal, Hyun Kyoung Lee
semanticscholar +1 more source
Diversity of satellite glia in sympathetic and sensory ganglia
bioRxiv, 2021 Satellite glia are the major glial type found in ganglia of the peripheral nervous system and wrap around cell bodies of sympathetic and sensory neurons that are very diverse. Other than their close physical association with peripheral neurons, little is
Aurelia A Mapps +5 more
semanticscholar +1 more source
Stress-induced despair behavior develops independently of the Ahr-RORγt axis in CD4 + cells
Scientific Reports, 2022 Current treatments for major depressive disorder are limited to neuropharmacological approaches and are ineffective for large numbers of patients. Recently, alternative means have been explored to understand the etiology of depression.
Courtney R. Rivet-Noor +8 more
doaj +1 more source
A Comparative Biology of Microglia Across Species
Frontiers in Cell and Developmental Biology, 2021 Microglia are unique brain-resident, myeloid cells. They have received growing interest for their implication in an increasing number of neurodevelopmental, acute injury, and neurodegenerative disorders of the central nervous system (CNS).
Kaushik Sharma +5 more
doaj +1 more source
SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models
EMBO Molecular Medicine, 2021 Astrocytes and microglia are brain‐resident glia that can establish harmful inflammatory environments in disease contexts and thereby contribute to the progression of neuronal loss in neurodegenerative disorders.
Oh-Chan Kwon +15 more
semanticscholar +1 more source
Nature Neuroscience, 2020 The human cortex comprises diverse cell types that emerge from an initially uniform neuroepithelium that gives rise to radial glia, the neural stem cells of the cortex.
Ugomma C. Eze +4 more
semanticscholar +1 more source