Results 21 to 30 of about 262,302 (346)

Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection

open access: yesNature Communications, 2020
Control over T. gondii infection in the brain involves microglial cells, but how these cells execute this control is not clear. Here the authors show that unlike IL-1β dominant macrophages, microglia are primed for gasdermin-D-dependent IL-1α production ...
Samantha J. Batista   +6 more
doaj   +1 more source

Protocol to downregulate GABAergic-astrocyte signaling via astrocyte-selective ablation of GABAB receptor in adult mice

open access: yesSTAR Protocols, 2022
Summary: Here, we present a protocol to selectively downregulate GABAB receptor (GABABR) expression in astrocytes of mouse medial prefrontal cortex (mPFC). We first describe the procedure of surgeries and viral injections.
Sara Mederos   +2 more
doaj   +1 more source

Characterizing circulating tumor cells using affinity-based microfluidic capture and AFM-based biomechanics

open access: yesSTAR Protocols, 2022
Summary: Elasticity and bio-adhesiveness of circulating tumor cells (CTCs) are important biomarkers of cancer. CTCs are rare in blood, thus their capture and atomic force microscopy (AFM)-based biomechanical characterization require use of ...
Muhammedin Deliorman   +2 more
doaj   +1 more source

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

open access: yesJournal of Neuroscience, 2014
The major cell classes of the brain differ in their developmental processes, metabolism, signaling, and function. To better understand the functions and interactions of the cell types that comprise these classes, we acutely purified representative ...
Ye Zhang   +16 more
semanticscholar   +1 more source

Celiac Immunogenic Potential of α-Gliadin Epitope Variants from Triticum and Aegilops Species [PDF]

open access: yes, 2019
The high global demand of wheat and its subsequent consumption arise from the physicochemical properties of bread dough and its contribution to the protein intake in the human diet.
Barro Losada, Francisco   +8 more
core   +1 more source

No Longer Underappreciated: The Emerging Concept of Astrocyte Heterogeneity in Neuroscience

open access: yesBrain Sciences, 2020
Astrocytes are ubiquitous in the central nervous system (CNS). These cells possess thousands of individual processes, which extend out into the neuropil, interacting with neurons, other glia and blood vessels.
Francisco Pestana   +4 more
doaj   +1 more source

Radial glia in the zebrafish brain: Functional, structural, and physiological comparison with the mammalian glia

open access: yesGlia, 2020
The neuroscience community has witnessed a tremendous expansion of glia research. Glial cells are now on center stage with leading roles in the development, maturation, and physiology of brain circuits.
Nathalie Jurisch-Yaksi   +2 more
semanticscholar   +1 more source

An Inflammation-Centric View of Neurological Disease: Beyond the Neuron [PDF]

open access: yes, 2018
Inflammation is a complex biological response fundamental to how the body deals with injury and infection to eliminate the initial cause of cell injury and effect repair.
Facci, Laura   +3 more
core   +2 more sources

Dynamic resources of the Sanità spring at Caposele (South Italy)

open access: yesAcque Sotterranee, 2014
The Sanità Spring at Caposele (NE of Campania – South Italy) is the main spring of the Sele river. Since the end of ‘800, it was indicated and was prospected as the possible base of the Acquedotto Pugliese for drinking the dry Apulia zone. The spring was
Massimo V. Civita, Katia Rostagno
doaj   +1 more source

Identification of region-specific astrocyte subtypes at single cell resolution

open access: yesNature Communications, 2020
Astrocytes are a major cell type in the central nervous system. Using single cell transcriptome sequencing, the authors identify multiple astrocyte subtypes in the adult mouse CNS, which map to distinct spatial locations and show correlations to cell ...
Mykhailo Y. Batiuk   +12 more
doaj   +1 more source

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