Results 11 to 20 of about 32,747 (256)

Loss of Beta-Cell Identity and Function as a Mechanism of Secondary Failure of Sulfonylurea Therapy in Diabetes. [PDF]

MedComm (2020)
ABSTRACT Sulfonylureas, commonly used to treat type 2 diabetes (T2D), often lose effectiveness over time when used as monotherapy; however, the underlying mechanisms remain unclear. To investigate the mechanisms of sulfonylurea failure, glibenclamide‐releasing pellets were implanted in KK mice, a polygenic model that spontaneously develops T2D. KK mice
Patel S, Yan Z, Remedi MS.
europepmc   +2 more sources

Functional expression of inwardly rectifying and ATP-sensitive potassium channels in human pulmonary artery smooth muscle and endothelial cells. [PDF]

J Physiol
Abstract figure legend Inwardly rectifying (Kir2) and ATP‐sensitive (KATP) potassium channels are functionally expressed in human pulmonary artery endothelial and smooth muscle cells. The schematic illustrates how Kir2‐ and KATP‐mediated K+ efflux contributes to VM regulation and pulmonary vascular tone.
Barreira B, Morales-Cano D, Moreno L, de Olaiz B, Adão R, Cogolludo A, Perez-Vizcaino F, Sancho M.   +7 more
europepmc   +2 more sources

Glibenclamide ameliorates the disrupted blood–brain barrier in experimental intracerebral hemorrhage by inhibiting the activation of NLRP3 inflammasome [PDF]

Brain and Behavior, 2019
Zuopeng Su
exaly   +2 more sources

Differential interaction of glimepiride and glibenclamide with the β-cell sulfonylurea receptor II [PDF]

, 1994
Glimepiride is a novel sulfonylurea for the treatment of type II-diabetic patients exhibiting different receptor binding kinetics to β-cell membranes with 8–9-fold higher koff rate and 2.5–3-fold higher kon rate compared to glibenclamide (see ...
Aguilar-Bryan, Aguilar-Bryan, Ashcroft, Bayley, De Weille, Ehle, Galizzi, Geisen, Geisen, Glossmann, Glossmann, Hogg, Hollemans, Kramer, Kramer, Kramer, Kramer, Martyr, Müller, Nelson, Nelson, Niki, Ozanne, Panten, Pomerantz, Repke, Schmid-Antomarchi, Schwanstecher, Skeer, Wessel   +29 more
core   +1 more source

Differential interaction of glimepiride and glibenclamide with the β-cell sulfonylurea receptor I. Binding characteristics [PDF]

, 1994
Glimepiride is a novel sulfonylurea drug for treatment of non-insulin-dependent diabetes mellitus with higher blood sugar lowering efficacy in diabetic patients than glibenclamide raising the question whether this characteristics is in line with ...
Aguilar-Bryan, Ashcroft, Ashcroft, Benovic, Bhathena, Boyd, Boyd, Boyd, Carpentier, Chick, French, Gaines, Geisen, Geisen, Gerich, Gylfe, Kaubisch, Kolterman, Kramer, Kramer, Müller, Nelson, Nelson, Niki, Niki, Niki, Niki, Panten, Popov, Praz, Schmid-Antomarchi, Schmid-Antomarchi, Sturgess, Sugiura, Weiland, Yalow   +35 more
core   +1 more source

PENGARUH PEMBERIAN EKSTRAK DAUN SALAM (Syzygium polyanthum Wight.) TERHADAP GLIBENKLAMID DALAM MENURUNKAN KADAR GLUKOSA DARAH MENCIT (Mus musculus) YANG DIINDUKSI ALOKSAN

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy), 2016
The use of herbal medicines and synthetic drugs simultaneously carried out by diabetics for the maintenance of blood glucose levels, such as the use of glibenclamide and bay leaf.
Nur Hikmah, Yuliet Yuliet, Khildah Khaerati   +2 more
doaj   +1 more source

The Effect of KATP Channel Blocker Glibenclamide on CGRP-Induced Headache and Hemodynamic in Healthy Volunteers

Frontiers in Physiology, 2021
BackgroundCalcitonin gene-related peptide (CGRP) dilates cranial arteries and triggers headache. The CGRP signaling pathway is partly dependent on activation of ATP-sensitive potassium (KATP) channels. Here, we investigated the effect of the KATP channel
Hande Coskun, Fatima Azzahra Elbahi, Fatima Azzahra Elbahi, Mohammad Al-Mahdi Al-Karagholi, Hashmat Ghanizada, Majid Sheykhzade, Messoud Ashina, Messoud Ashina   +7 more
doaj   +1 more source

A spontaneous increase in intracellular Ca2+ in metaphase II human oocytes in vitro can be prevented by drugs targeting ATP-sensitive K+ channels [PDF]

, 2015
STUDY QUESTION: Could drugs targeting ATP-sensitive K+ (KATP) channels prevent any spontaneous increase in intracellular Ca2+ that may occur in human metaphase II (MII) oocytes under in vitro conditions?
Barratt, Christopher L. R., Barratt, Evelyn, Brown, Sean G., Dasai, Navin, Drew, Ellen, Fernandes, Gonçalo, Gall, Mandy, Jovanović, Aleksandar, Kozlova, Natalia, Madamidola, Oladipo A., Martins da Silva, Sarah J., Milne, Alison M., Mojadadi, Albaraa, Whalley, Katherine M.   +13 more
core   +6 more sources

The Effect of Long Term use of Glibenclamide on Serum and Urinary Sodium and Potassium Level in Type 2 DM Patients

Iraqi Journal of Pharmaceutical Sciences, 2017
Long-term use of sulfonylureas including chlorpropamide, is known to potentiate the antidiuretic action of arginine vasopressin (AVP), predisposing to hyponatremia.The present study was designed to evaluate the effect of long term use of glibenclamide on
Ali A. Ali
doaj   +3 more sources

Comparative study between Metformin, Glibenclamide and their combination in newly diagnosed diabetic (type II) patients in Hawler City

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2012
Type 2 diabetes mellitus is a complex progressive disorder characterized by impaired insulin sensitivity, reduced insulin secretion and progressive failure of pancreatic β – cells.
Sazan D. S., Kassim J.S., Ansam N.H.
doaj   +1 more source