Results 71 to 80 of about 32,747 (256)

KATP Channel Openers Have Opposite Effects on Mitochondrial Respiration Under Different Energetic Conditions [PDF]

, 2008
Mitochondrial (m) KATP channel opening has been implicated in triggering cardiac preconditioning. Its consequence on mitochondrial respiration, however, remains unclear. We investigated the effects of two different KATP channel openers and antagonists on
Camara, Amadou K.S., Eells, Janis T., Heinen, André, Henry, Michele M., Riess, Matthias L., Stowe, David F.   +5 more
core   +2 more sources

Development and Optimization of a Green Stability Indicating HPLC Method for the Determination Metformin HCL and Glibenclamide in their Dosage Form [PDF]

, 2022
Basma M. Selim
openalex   +1 more source

The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities

MedComm, Volume 7, Issue 3, March 2026.
Diverse diseases converge on NLRP3. We depict a discovery‐to‐clinic track: high‐throughput/phenotypic screens, structure‐guided design, and modality innovation (allosteric inhibitors, interface blockers, degraders) deliver third‐generation, disease‐tailored NLRP3 control.
Chan Zou, Shilong Jiang, Hui Li, Kai Zhao, Dongshen Cao, Guoping Yang   +5 more
wiley   +1 more source

Mycochemical Diversity and Therapeutic Potential of Hymenochaetoid Fungi from Central Asia: Regional and Global Perspectives

New Zealand Journal of Botany, Volume 64, Issue 1, March 2026.
Central Asia harbors a rich yet understudied assemblage of wood‐inhabiting Hymenochaetoid fungi. This review delivers the first comprehensive synthesis of 43 poroid species representing 18 genera documented across montane forests, steppes, and xeric habitats.
Yusufjon Gafforov, Milena Rašeta, Sylvie Rapior, Manzura Yarasheva, Oksana Mykchaylova, Rustamjon Allaberdiev, Şule İnci, Dilfuza Berdieva, Arshad Mehmood Abbasi, Shikhnazar Khodjaev, Dian‐Ming Hu, Weijun Yang, Abudujilili Abuduaini, Maria Letizia Taddei, Mengcen Wang, Islomjon Urinboev, Jiajia Chen   +16 more
wiley   +1 more source

Glibenclamide, a Sur1-Trpm4 antagonist, does not improve outcome after collagenase-induced intracerebral hemorrhage.

PLoS ONE, 2019
The sulfonylurea 1 transient receptor potential melastatin 4 (Sur1-Trpm4) receptor is selectively expressed after intracerebral hemorrhage (ICH). This upregulation contributes to increases in intracellular sodium.
Cassandra M Wilkinson, Paul S Brar, Celine J Balay, Frederick Colbourne   +3 more
doaj   +1 more source

Glibenclamide Reduces Primary Human Monocyte Functions Against Tuberculosis Infection by Enhancing M2 Polarization

Frontiers in Immunology, 2018
Tuberculosis (TB) is a global public health problem, which is caused by Mycobacterium tuberculosis (Mtb). Type 2 diabetes mellitus (T2DM) is one of the leading predisposing factors for development of TB after HIV/AIDS. Glibenclamide is a widely used anti-
Chidchamai Kewcharoenwong, Chidchamai Kewcharoenwong, Satria A. Prabowo, Satria A. Prabowo, Gregory J. Bancroft, Gregory J. Bancroft, Helen A. Fletcher, Helen A. Fletcher, Ganjana Lertmemongkolchai, Ganjana Lertmemongkolchai   +9 more
doaj   +1 more source

Magnetic Resonance Imaging Pilot Study of Intravenous Glyburide in Traumatic Brain Injury. [PDF]

, 2020
Pre-clinical studies of traumatic brain injury (TBI) show that glyburide reduces edema and hemorrhagic progression of contusions. We conducted a small Phase II, three-institution, randomized placebo-controlled trial of subjects with TBI to assess the ...
Aldrich, Christina, Eisenberg, Howard M, Hayman, Erik G, He, Feng, Jain, Sonia, Okonkwo, David O, Pasternak, Ofer, Shenton, Martha E, Simard, J Marc   +8 more
core  

Haemostasiologic effects of various glucose-lowering medications in type 2 diabetes mellitus

Кардиоваскулярная терапия и профилактика, 2010
Aim. To evaluate the effects of insulin and other glucose-lowering medications on platelet function and coagulation haemostasis in patients with Type 2 diabetes mellitus (DM-2). Material and methods.
G. G. Petrik, S. A. Pavlishchuk
doaj  

Safety and efficacy of glibenclamide on cerebral oedema following aneurysmal subarachnoid haemorrhage: a randomised, double-blind, placebo-controlled clinical trial

Stroke and Vascular Neurology
Background Glibenclamide has garnered attention due to its multifaceted neuroprotective effects in cases of acute central nervous system injury.
Hao Zhao, Hongqi Zhang, Xuebing Feng, Ning Wang, Xin Qu, Meng Qi, Tongyu Zhang, Yueqiao Xu   +7 more
doaj   +1 more source

Diabetes induced by gain-of-function mutations in the Kir6.1 subunit of the KATP channel [PDF]

, 2017
Gain-of-function (GOF) mutations in the pore-forming (Kir6.2) and regulatory (SUR1) subunits of K(ATP) channels have been identified as the most common cause of human neonatal diabetes mellitus. The critical effect of these mutations is confirmed in mice
Ashcroft, Benninger, Colin G. Nichols, Flagg, Flanagan, Girard, Gloyn, Gloyn, Hamilton-Shield, Hattersley, Herrera, Inagaki, Jonathan B. Friedman, Koster, Koster, Koster, Li, Maria S. Remedi, Marshall, Masia, Massa, Miki, Ng, Nichols, Pagliuca, Pearson, Polak, Remedi, Remedi, Segerstolpe, Sperling, Vaxillaire, Villareal, Wambach, Wang, Wellman, Wiltshire   +36 more
core   +2 more sources