Results 81 to 90 of about 32,747 (256)

Therapeutic Activities and Phytochemical Composition of Helianthus annuus L. Extracts

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
ABSTRACT The sunflower (Helianthus annuus L.) is a plant commonly used in agriculture and the fuel industry, as well as being an ornamental garden plant. However, its biologically active compounds make it an interesting plant for medicinal purposes. This review evaluated the phytochemistry of sunflower leaves, stems, receptacles, flowers, seeds, and ...
Marina dos Santos Barreto, Wesley Lisboa de Jesus, Maria Eduarda de Britto Sá, Jessiane Bispo de Souza, Ronaldy Santana Santos, Júlia Santana Lisboa, Pedro Henrique Macedo Moura, Deise Maria Rego Rodrigues Silva, Eloia Emanuelly Dias Silva, Lysandro Pinto Borges, Adriana Gibara Guimarães   +10 more
wiley   +1 more source

A Protective Role of Glibenclamide in Inflammation-Associated Injury

Mediators of Inflammation, 2017
Glibenclamide is the most widely used sulfonylurea drug for the treatment of type 2 diabetes mellitus (DM). Recent studies have suggested that glibenclamide reduced adverse neuroinflammation and improved behavioral outcomes following central nervous ...
Gensheng Zhang, Xiuhui Lin, Shufang Zhang, Huiqing Xiu, Chuli Pan, Wei Cui   +5 more
doaj   +1 more source

Ricinus Communis: Nutritional Importance, Health Benefits, and Industrial Applications

eFood, Volume 7, Issue 1, February 2026.
The current paper summarizes the nutritional composition, phytochemistry, health benefits, safety studies, and applications of castor beans and their oil. Moreover, the diverse bioactive compounds, including saponins, emodins, terpenoids, anthraquinones, flavonoids, steroids, and alkaloids, exhibit therapeutic properties such as antioxidant, anticancer,
Hassan Raza, Muhammad Tauseef Sultan, Asad Abbas, Aimen Mazhar, Ahmad Mujtaba Noman, Muhammad Imran, Muzzamal Hussain, Ehab M. Mostafa, Ahmed H. El‐Ghorab, Mohammed M. Ghoneim, Samy Selim, Mohamed A. Abdelgawad, Anjuman Gul Memon, Entessar Al Jbawi   +13 more
wiley   +1 more source

Glibenclamide population pharmacokinetic/pharmacodynamic modeling in South African type 2 diabetic subjects

Clinical Pharmacology: Advances and Applications, 2016
Virendra Rambiritch,1 Poobalan Naidoo,2 Goonaseelan Pillai3 1Pharmacology Department, University of KwaZulu-Natal, Durban, 2Department of Internal Medicine, RK Khan Regional Hospital, Chatsworth, South Africa; 3Scientific Capability Development, Novartis
Rambiritch V, Naidoo P, Pillai G
doaj  

Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM

eLife, 2019
ATP-sensitive potassium (KATP) channels composed of a pore-forming Kir6.2 potassium channel and a regulatory ABC transporter sulfonylurea receptor 1 (SUR1) regulate insulin secretion in pancreatic β-cells to maintain glucose homeostasis.
Gregory M Martin, Min Woo Sung, Zhongying Yang, Laura M Innes, Balamurugan Kandasamy, Larry L David, Craig Yoshioka, Show-Ling Shyng   +7 more
doaj   +1 more source

Nutritional and Health Potential of Edible Seeds: Micronutrient Bioavailability and Mechanistic Insights

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Their bioactive constituents act through antioxidant, anti‐inflammatory, and metabolic‐regulating mechanisms, validating their classification as functional foods. Evidence from clinical and biochemical studies largely supports these benefits, although some claims stem from preliminary or in vitro findings.
Nighat Raza, Alina Sadaf, Reeha Mushtaq, Mirza Abid Mehmood, Luqman Amrao, Fakhar Islam, Muhammad Afzaal, Mohd Asif Shah   +7 more
wiley   +1 more source

Glibenclamide impairs responses of neutrophils against Burkholderia pseudomallei by reduction of intracellular glutathione. [PDF]

, 2016
The major risk factor for melioidosis, an infectious disease caused by B. pseudomallei, is diabetes mellitus. More than half of diabetic melioidosis patients in Thailand were prescribed glibenclamide.
Ato, Manabu, Bancroft, Gregory J, Kewcharoenwong, Chidchamai, Lertmemongkolchai, Ganjana, Nithichanon, Arnone, Rinchai, Darawan   +5 more
core   +1 more source

Delivering Diabetes Care in the Philippines and Vietnam: Policy and Practice Issues [PDF]

, 2013
The aim of this study is the comparison of 2 studies looking at the barriers to access of diabetes care and medicines in the Philippines and Vietnam. These studies used the Rapid Assessment Protocol for Insulin Access.
Beran, D, Higuchi, M
core  

Glucagon-like peptide-1 derived cardioprotection does not utilize a KATP-channel dependent pathway: mechanistic insights from human supply and demand ischemia studies. [PDF]

, 2016
BACKGROUND: Glucagon-like peptide-1 (7-36) amide (GLP-1) protects against stunning and cumulative left ventricular dysfunction in humans. The mechanism remains uncertain but GLP-1 may act by opening mitochondrial K-ATP channels in a similar fashion to ...
Axell, Richard G, Brown, Adam J, Clarke, Sophie J, Dutka, David P, Giblett, Joel P, Hoole, Stephen P, McCormick, Liam, O'Sullivan, Michael, Read, Philip A, Reinhold, Johannes, West, Nick EJ, White, Paul A   +11 more
core   +4 more sources

Diabetes management in maternally inherited diabetes and deafness (MIDD): A review and a proposed treatment algorithm

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 826-839, February 2026.
Abstract Maternally inherited diabetes and deafness (MIDD) is a mitochondrial disorder usually caused by the variant m.3243A>G in the MT‐TL1 gene. We have proposed that diabetes in MIDD arises from a combination of insulin resistance and impaired β‐cell function that is more likely to occur in the presence of high skeletal muscle heteroplasmy and ...
Ahsen Chaudhry, David M. Thompson, Jean‐Pierre Chanoine   +2 more
wiley   +1 more source